Q58270 (IDSA_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short chain isoprenyl diphosphate synthase
EC=2.5.1.-

Gene names

Name:	idsA
Ordered Locus Names:	MJ0860

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 3 magnesium ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FPP/GGPP synthase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 327	327	Short chain isoprenyl diphosphate synthase		PRO_0000123970
Sites
	Metal binding	87	1	Magnesium 1 By similarity
	Metal binding	87	1	Magnesium 2 By similarity
	Metal binding	91	1	Magnesium 1 By similarity
	Metal binding	91	1	Magnesium 2 By similarity
	Metal binding	217	1	Magnesium 3 By similarity
	Binding site	48	1	Isopentenyl diphosphate By similarity
	Binding site	51	1	Isopentenyl diphosphate By similarity
	Binding site	80	1	Isopentenyl diphosphate By similarity
	Binding site	96	1	Allylic substrate By similarity
	Binding site	97	1	Isopentenyl diphosphate By similarity
	Binding site	176	1	Allylic substrate By similarity
	Binding site	177	1	Allylic substrate By similarity
	Binding site	214	1	Allylic substrate By similarity
	Binding site	231	1	Allylic substrate By similarity
	Binding site	241	1	Allylic substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58270 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 07D68AC9BD657DAC	FASTA	327	37,569
	10 20 30 40 50 60 MKELFKRGGI MLFDKNILQK IDEELKTYVD KDDKLYNASK HLLFAGGKRI RPYLTVVTYM 70 80 90 100 110 120 LKKDDIEEVL PAAAAVELIH NYTLIHDDIM DNDDERRGKP TVHVVYGEPM AILAGDLLYA 130 140 150 160 170 180 KAFEAVSRIK DNKKAHEVLK ILSKACVEVC EGQAMDMEFE NYYPTMEEYL DMIRKKTGAL 190 200 210 220 230 240 LEASVGIGAV MADCNEEERE ALKEYAKRIG LTFQIQDDVL DLIGDQKKLG KPVGSDIREG 250 260 270 280 290 300 KKTIIVIHAL KTLDEDKKKR LLEILGNKNV KDEEIKEAIE ILKPSIEYAK ELMKQKTEEA 310 320 KEYLKIFNKD RRKVLEDLAD FIMSRIY

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98865.1.
PIR	D64407.
RefSeq	NP_247855.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58270.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJ0860.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB98865; AAB98865; MJ_0860.
GeneID	1451749.
KEGG	mja:MJ_0860.
Phylogenomic databases
eggNOG	COG0142.
KO	K13787.
OMA	DIMDNDD.
ProtClustDB	CLSK876365.
Family and domain databases
Gene3D	1.10.600.10. 1 hit.
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
PANTHER	PTHR12001. PTHR12001. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
SUPFAM	SSF48576. Terpenoid_synth. 1 hit.
PROSITE	PS00723. POLYPRENYL_SYNTHASE_1. 1 hit. PS00444. POLYPRENYL_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDSA_METJA

Accession

Primary (citable) accession number: Q58270

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program