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Q58264 (MTRH_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tetrahydromethanopterin S-methyltransferase subunit H
EC=2.1.1.86
Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H
Gene names
Name:mtrH
Ordered Locus Names:MJ0854
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of mtrA By similarity. HAMAP MF_01501

Catalytic activity

5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01501

Pathway

One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. HAMAP MF_01501

Subunit structure

The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity.

Sequence similarities

Belongs to the mtrH family.

Sequence caution

The sequence AAB98859.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Tetrahydromethanopterin S-methyltransferase subunit H HAMAP MF_01501
PRO_0000147563

Sequences

Sequence LengthMass (Da)Tools
Q58264 [UniParc].

Last modified December 15, 2003. Version 2.
Checksum: 370E20B41F5CDA00

FASTA31934,603
        10         20         30         40         50         60 
MFKFDREQMV VEIAGRKIGG QPGEYPTALA GTIFYARHKI VEDERKGIFD KAAAEDLINK 

        70         80         90        100        110        120 
QAEMEDITGN PALVQVFGGT PEALVNYIDF VAEVWDGPML LDSTSGEARM AAAKRATEAG 

       130        140        150        160        170        180 
YAKQCIYNSI NVSIDEQEYQ VLVESDLEAS IVLCFDPMDP TVEGKINVLT NGGKTADKGM 

       190        200        210        220        230        240 
LELAEKAGIK YPLIDTAVTP LGNGAGAAVR ASFAVKALFG YPVGSGIHNI PSAWDWLREF 

       250        260        270        280        290        300 
RKQLREAGER EKAKDIHHVC DVGANLVQVM ASGDFVLYGP IDNAYMTFPA VAMVDAIIAE 

       310 
AAKELGIEPI DTHPFKKLV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB98859.1. Different initiation.
PIRF64406.
RefSeqNP_247848.2. NC_000909.1.

3D structure databases

ProteinModelPortalQ58264.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1451742.
GenomeReviewsGene locus MJ0854 in contig L77117_GR.
KEGGmja:MJ_0854.
NMPDRfig|243232.1.peg.885.
TIGRMJ0854.

Phylogenomic databases

HOGENOMHBG512918.
OMAYARHKIV.
ProtClustDBPRK00979.

Enzyme and pathway databases

BioCycMJAN243232:MJ_0854-MONOMER.

Family and domain databases

HAMAPMF_01501. MtrH.
[Tree]
InterProIPR011005. Dihydropteroate_synth-like.
IPR023467. MeTrfase_MtrH/CmuB.
IPR000489. Pterin-binding.
[Graphical view]
Gene3DG3DSA:3.20.20.20. Dhdropt_synth. 1 hit.
KOK00584.
PfamPF02007. MtrH. 1 hit.
[Graphical view]
PIRSFPIRSF004960. MtrH_MtxH. 1 hit.
ProDomPD009948. MtrH_MeTrfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF51717. DHP_synth_like. 1 hit.
TIGRFAMsTIGR01114. MtrH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMTRH_METJA
AccessionPrimary (citable) accession number: Q58264
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 2003
Last modified: November 16, 2011
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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