Q58259 (MTRC_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetrahydromethanopterin S-methyltransferase subunit C
EC=2.1.1.86

Alternative name(s):
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit C

Gene names

Name:	mtrC
Ordered Locus Names:	MJ0849

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step By similarity. HAMAP MF_01096
Catalytic activity	5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate. HAMAP MF_01096
Pathway	One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. HAMAP MF_01096
Subunit structure	The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential HAMAP MF_01096.
Sequence similarities	Belongs to the mtrC family.

Ontologies

Keywords
Biological process	Methanogenesis One-carbon metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	tetrahydromethanopterin S-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Tetrahydromethanopterin S-methyltransferase subunit C HAMAP MF_01096		PRO_0000147522
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	75 – 95	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	202 – 222	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q58259 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 07FB20DA394A7FE0	FASTA	265	27,804
	10 20 30 40 50 60 MSHGGGGHAA ELYPEEQIFA VGIALSLVGC YLANFLSPYG LGMLIGGLLA SAACVAGANT 70 80 90 100 110 120 VRKVAAYGLG TGVPSIGMVS LGMGTLAAVA GVLIPDYFNL PYLVAPIITL IVSAVIGYIV 130 140 150 160 170 180 GRLTVNPVGM KIPIMVRSMT FLSIAGAMAL LGFTVAYVGS LEPQKYIDYA LNNGMMALAF 190 200 210 220 230 240 IAAGMAILHP FNACLGPNES HKRTLTLAVA CGFITWFVFS VVKLDIVSII VSIILWAIVY 250 260 VKFVKMSFKD ACAVLHVPEI PKKEE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98854.1.
PIR	A64406.
RefSeq	NP_247843.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58259.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451737.
GenomeReviews	Gene locus MJ0849 in contig L77117_GR.
KEGG	mja:MJ_0849.
NMPDR	fig|243232.1.peg.880.
TIGR	MJ0849.
Phylogenomic databases
HOGENOM	HBG542041.
OMA	FNACLGP.
ProtClustDB	PRK01030.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0849-MONOMER.
Family and domain databases
HAMAP	MF_01096. MtrC. [Tree]
InterPro	IPR005865. THM_MeTrfase_su_C. [Graphical view]
KO	K00579.
Pfam	PF04211. MtrC. 1 hit. [Graphical view]
PIRSF	PIRSF006530. MtrC. 1 hit.
ProDom	PD013899. THM_MeTrfase_su_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01148. MtrC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTRC_METJA

Accession

Primary (citable) accession number: Q58259

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program