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Q58252

- MCRB_METJA

UniProt

Q58252 - MCRB_METJA

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Protein
Methyl-coenzyme M reductase I subunit beta
Gene
mcrB, MJ0842
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide By similarity.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase I subunit beta (EC:2.8.4.1)
Short name:
MCR I beta
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mcrB
Ordered Locus Names:MJ0842
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Methyl-coenzyme M reductase I subunit beta
PRO_0000147465Add
BLAST

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains By similarity.

Protein-protein interaction databases

STRINGi243232.MJ0842.

Structurei

3D structure databases

ProteinModelPortaliQ58252.
SMRiQ58252. Positions 6-447.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4054.
KOiK00401.
OMAiFREPLKY.
PhylomeDBiQ58252.

Family and domain databases

Gene3Di1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProiIPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view]
PfamiPF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMiSSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03257. met_CoM_red_bet. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58252-1 [UniParc]FASTAAdd to Basket

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MIPMVKYKDT INLYDEKGKL VEENVPLEAI SPLHNPTIQK LVKDVKRTVA    50
VNLAGIENAL RTGQVGGKGC MIKGRELDLP IVENAETIAE YVEKVVRVSE 100
DDDTSIKLIN DGKQMAVQIP SKRLDVAAEY SVSVLVTAQA LKEAIIRTFD 150
VDIFDAPMVH AAVLGGYPHE VTMKGSNIAA LLGSPLSLEG PGYALRNIMA 200
NHFVACTKKN VMNAVAFAAI MEQTAMFEMG DAVGLFERLH LLGLAYQGLN 250
ADNLVIDLVK ANGKNGTVGT VVASVVERAL EDGVIKEDKT LPSGFKLYKP 300
VDVAKWNAYA AAGLVAAAIV NCGAARAAQN IASTILYYND ILEYETGLPG 350
VDFGRAEGTA VGFSFFSHSI YGGGGPGIFN GNHIVTRHSK GFAIPPVAAA 400
MCLDAGTQMF SPERTSALVG TVFSAIDEFR EPLKYVIKGA LEVKDKI 447
Length:447
Mass (Da):47,789
Last modified:December 15, 1998 - v2
Checksum:i52C76BB2C4C425E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98847.1.
RefSeqiNP_247836.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98847; AAB98847; MJ_0842.
GeneIDi1451730.
KEGGimja:MJ_0842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98847.1 .
RefSeqi NP_247836.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58252.
SMRi Q58252. Positions 6-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98847 ; AAB98847 ; MJ_0842 .
GeneIDi 1451730.
KEGGi mja:MJ_0842.

Phylogenomic databases

eggNOGi COG4054.
KOi K00401.
OMAi FREPLKY.
PhylomeDBi Q58252.

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .

Family and domain databases

Gene3Di 1.20.840.10. 2 hits.
3.30.70.470. 1 hit.
InterProi IPR022681. MCR_a/b_chain_a-bundle.
IPR008924. Me_CoM_Rdtase_asu/bsu_C.
IPR015823. Me_CoM_Rdtase_asu_N_sub2.
IPR003179. Me_CoM_Rdtase_bsu.
IPR022679. Me_CoM_Rdtase_bsu_C.
IPR022680. Me_CoM_Rdtase_bsu_N.
IPR009024. Me_CoM_Rdtase_Fd-like_fold.
[Graphical view ]
Pfami PF02241. MCR_beta. 1 hit.
PF02783. MCR_beta_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000263. Meth_CoM_rd_beta. 1 hit.
SUPFAMi SSF48081. SSF48081. 1 hit.
SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03257. met_CoM_red_bet. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMCRB_METJA
AccessioniPrimary (citable) accession number: Q58252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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