Q58235 (FKBP2_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative FKBP-type peptidyl-prolyl cis-trans isomerase MJ0825
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Rotamase

Gene names

Ordered Locus Names:

MJ0825

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Molecular function	Isomerase Rotamase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 231

231

Putative FKBP-type peptidyl-prolyl cis-trans isomerase MJ0825

PRO_0000075377

Regions

Domain

5 – 92

88

PPIase FKBP-type

Secondary structure

1

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231

Helix Strand Turn

Details...

Beta strand

7 – 16

10

Beta strand

19 – 24

6

Helix

26 – 31

6

Beta strand

44 – 47

4

Beta strand

50 – 53

4

Helix

55 – 63

9

Beta strand

69 – 74

6

Helix

76 – 78

3

Helix

85 – 87

3

Beta strand

88 – 92

5

Helix

93 – 98

6

Beta strand

108 – 111

4

Beta strand

114 – 122

9

Beta strand

125 – 129

5

Turn

133 – 136

4

Beta strand

139 – 149

11

Helix

152 – 163

12

Beta strand

171 – 175

5

Beta strand

178 – 182

5

Helix

187 – 189

3

Helix

193 – 207

15

Beta strand

213 – 221

9

Sequences

	Sequence		Length	Mass (Da)
	Q58235 [UniParc]. Last modified December 15, 1998. Version 2. Checksum: ABD9AD1DB1B6C420	FASTA	231	25,947
	10 20 30 40 50 60 MVEKGKMVKI SYDGYVDGKL FDTTNEELAK KEGIYNPAMI YGPVAIFAGE GQVLPGLDEA 70 80 90 100 110 120 ILEMDVGEER EVVLPPEKAF GKRDPSKIKL IPLSEFTKRG IKPIKGLTIT IDGIPGKIVS 130 140 150 160 170 180 INSGRVLVDF NHELAGKEVK YRIKIEEVVD DKKNIVKEIV KMYVPRLSDV KVTIRNGTVK 190 200 210 220 230 IELPEFAPFI PNIQTAKMAI ANEILKRLED AEKVSFVETF ERKKETKEEN K

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L77117 Genomic DNA. Translation: AAB98824.1.

RefSeq

NP_247816.1. NC_000909.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PR9	X-ray	1.95	A	1-150	[»]
3PRA	X-ray	2.40	A/B	1-150	[»]
3PRB	X-ray	2.20	A/B	1-231	[»]
3PRD	X-ray	3.30	A	1-231	[»]

ProteinModelPortal

Q58235.

ModBase

Search...

Protein-protein interaction databases

STRING

243232.MJ0825.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAB98824; AAB98824; MJ_0825.

GeneID

1451708.

KEGG

mja:MJ_0825.

Phylogenomic databases

eggNOG

COG1047.

KO

K03775.

OMA

ILVDFNH.

ProtClustDB

CLSK876347.

Family and domain databases

InterPro

IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]

PANTHER

PTHR10516. PTHR10516. 1 hit.

Pfam

PF00254. FKBP_C. 1 hit.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q58235.

Entry information

Entry name

FKBP2_METJA

Accession

Primary (citable) accession number: Q58235

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 15, 1998
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program