Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q58154 (HDRC1_METJA)

Last modified February 9, 2010. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CoB--CoM heterodisulfide reductase iron-sulfur subunit C 1
    EC=1.8.98.1
Gene names
Name: hdrC1
Ordered Locus Names: MJ0744
OrganismMethanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]
Taxonomic identifier2190 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length194 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B) By similarity.

Catalytic activity

Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.

Cofactor

Binds 2 4Fe-4S clusters per subunit By similarity.

Pathway

Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.

Subunit structure

The heterodisulfide reductase is composed of three subunits; hdrA, hdrB and hdrC By similarity.

Sequence similarities

Belongs to the hdrC family.

Contains 2 4Fe-4S ferredoxin-type domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 194194CoB--CoM heterodisulfide reductase iron-sulfur subunit C 1
PRO_0000150073

Regions

Domain25 – 55314Fe-4S ferredoxin-type 1
Domain67 – 98324Fe-4S ferredoxin-type 2

Sites

Metal binding351Iron-sulfur 1 (4Fe-4S) Potential
Metal binding381Iron-sulfur 1 (4Fe-4S) Potential
Metal binding411Iron-sulfur 1 (4Fe-4S) Potential
Metal binding451Iron-sulfur 2 (4Fe-4S) Potential
Metal binding791Iron-sulfur 2 (4Fe-4S) Potential
Metal binding821Iron-sulfur 2 (4Fe-4S) Potential
Metal binding851Iron-sulfur 2 (4Fe-4S) Potential
Metal binding891Iron-sulfur 1 (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q58154-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8871167DFD0C83AD

FASTA19422,016
        10         20         30         40         50         60 
MVIYAQKDIS NDFIKEIIKT GEILGEGHVS SFKACYQCGT CTGSCPSGRI TAFRTRKLIR 

        70         80         90        100        110        120 
YAQFGMKSAI IDSEDLWMCT TCYECYERCP RTVKITDIIK VLRNIAAREG KMAEAHKKTA 

       130        140        150        160        170        180 
LYVFKTGHAV PINDQIKKAR KEIGLTEIPP TTHKYPDALE VVRGIMKDLR FCDMVGICTE 

       190 
TMQLKPVEWK DMSE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98738.1.
PIRH64392.
RefSeqNP_247729.1.

3D structure databases

SMRQ58154. Positions 29-114.
ModBaseSearch...

Genome annotation databases

GeneID1451621.
GenomeReviewsGene locus MJ0744 in contig L77117_GR.
KEGGmja:MJ0744.
NMPDRfig|243232.1.peg.766.
TIGRMJ0744.

Phylogenomic databases

HOGENOMHBG542047.
OMAEIPPTTH.

Enzyme and pathway databases

BRENDA1.8.98.1. 256362.

Family and domain databases

InterProIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017680. CoB/CoM_hetero-S_Rdtase_csu.
IPR012285. Fum_reductase_C.
IPR009051. Helical_ferredxn.
[Graphical view]
Gene3DG3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMsTIGR03290. CoB_CoM_SS_C. 1 hit.
PROSITEPS00198. 4FE4S_FER_1. 2 hits.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHDRC1_METJA
AccessionPrimary (citable) accession number: Q58154
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents