Reviewed, UniProtKB/Swiss-Prot Q58154 (HDRC1_METJA)

Names and origin

Protein names

Recommended name:
    CoB--CoM heterodisulfide reductase iron-sulfur subunit C 1
    EC=1.8.98.1

Gene names

Name:	hdrC1
Ordered Locus Names:	MJ0744

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B) By similarity.
Catalytic activity	Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.
Cofactor	Binds 2 4Fe-4S clusters per subunit By similarity.
Pathway	Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.
Subunit structure	The heterodisulfide reductase is composed of three subunits; hdrA, hdrB and hdrC By similarity.
Sequence similarities	Belongs to the hdrC family. Contains 2 4Fe-4S ferredoxin-type domains.

Ontologies

Keywords
Biological process	Methanogenesis
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cofactor metabolic process Inferred from electronic annotation. Source: InterPro methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW CoB--CoM heterodisulfide reductase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	CoB--CoM heterodisulfide reductase iron-sulfur subunit C 1		PRO_0000150073
Regions
	Domain	25 – 55	31	4Fe-4S ferredoxin-type 1
	Domain	67 – 98	32	4Fe-4S ferredoxin-type 2
Sites
	Metal binding	35	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	38	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	41	1	Iron-sulfur 1 (4Fe-4S) Potential
	Metal binding	45	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	79	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	82	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	85	1	Iron-sulfur 2 (4Fe-4S) Potential
	Metal binding	89	1	Iron-sulfur 1 (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q58154-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8871167DFD0C83AD	FASTA	194	22,016
	10 20 30 40 50 60 MVIYAQKDIS NDFIKEIIKT GEILGEGHVS SFKACYQCGT CTGSCPSGRI TAFRTRKLIR 70 80 90 100 110 120 YAQFGMKSAI IDSEDLWMCT TCYECYERCP RTVKITDIIK VLRNIAAREG KMAEAHKKTA 130 140 150 160 170 180 LYVFKTGHAV PINDQIKKAR KEIGLTEIPP TTHKYPDALE VVRGIMKDLR FCDMVGICTE 190 TMQLKPVEWK DMSE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98738.1.
PIR	H64392.
RefSeq	NP_247729.1.
3D structure databases
SMR	Q58154. Positions 29-114.
ModBase	Search...
Genome annotation databases
GeneID	1451621.
GenomeReviews	Gene locus MJ0744 in contig L77117_GR.
KEGG	mja:MJ0744.
NMPDR	fig|243232.1.peg.766.
TIGR	MJ0744.
Phylogenomic databases
HOGENOM	HBG542047.
OMA	EIPPTTH.
Enzyme and pathway databases
BRENDA	1.8.98.1. 256362.
Family and domain databases
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR017680. CoB/CoM_hetero-S_Rdtase_csu. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. [Graphical view]
Gene3D	G3DSA:1.10.1060.10. Fum_reductase_C. 1 hit.
TIGRFAMs	TIGR03290. CoB_CoM_SS_C. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HDRC1_METJA

Accession

Primary (citable) accession number: Q58154

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)