Q58153 (HDRB1_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CoB--CoM heterodisulfide reductase subunit B 1
EC=1.8.98.1

Gene names

Name:	hdrB1
Ordered Locus Names:	MJ0743

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction By similarity.
Catalytic activity	Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine.
Pathway	Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1.
Subunit structure	The heterodisulfide reductase is composed of three subunits; hdrA, hdrB and hdrC By similarity.
Sequence similarities	Belongs to the hdrB family.

Ontologies

Keywords
Biological process	Methanogenesis
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cofactor metabolic process Inferred from electronic annotation. Source: InterPro methanogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	CoB--CoM heterodisulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	CoB--CoM heterodisulfide reductase subunit B 1		PRO_0000150065

Sequences

	Sequence		Length	Mass (Da)
	Q58153 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C8D5DDCE6FDC8560	FASTA	294	33,310
	10 20 30 40 50 60 MEFVFFLGCI APNRYPGIEK ATYITMEKLG IKLHPFEKAS CCPAPGVFGS FDLKTWLTLA 70 80 90 100 110 120 ARNLCMAEEV EMDILTICNG CYGSLYEANH LLKENEKARK MVNEILSKYG LEYKGKVRVR 130 140 150 160 170 180 HLPEVLYYDL GVDRIKEEIT NPLNVNVAVH YGCHYLKPTD IKKLESSERP RSFDELVEAL 190 200 210 220 230 240 GAVSVNYKDK NMCCGAGGGV RARNLDVALK MTKTKLENIK EAKADCITEV CPFCHLQFDR 250 260 270 280 290 GQVEIKEKFG EEYNIPVIHY SQLLGLAMGM SPKDVALDLH FIPTDEFIKK IDRH

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98737.1.
PIR	G64392.
RefSeq	NP_247728.1. NC_000909.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451620.
GenomeReviews	Gene locus MJ0743 in contig L77117_GR.
KEGG	mja:MJ_0743.
NMPDR	fig|243232.1.peg.765.
TIGR	MJ0743.
Phylogenomic databases
HOGENOM	HBG513215.
OMA	VHYGCHY.
ProtClustDB	CLSK876313.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0743-MONOMER.
Family and domain databases
InterPro	IPR017678. CoB/CoM_hetero-S_Rdtase_bsu. IPR004017. Cys_rich_dom. [Graphical view]
KO	K03389.
Pfam	PF02754. CCG. 2 hits. [Graphical view]
TIGRFAMs	TIGR03288. CoB_CoM_SS_B. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HDRB1_METJA

Accession

Primary (citable) accession number: Q58153

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program