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Q58134 (OGG1_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:MJ0724
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Biophysicochemical properties

pH dependence:

Optimum pH is 8.5. HAMAP-Rule MF_00241

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159562

Sites

Active site1291

Experimental info

Mutagenesis1291K → S: Loss of activity. Ref.2

Secondary structure

.............................. 207
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q58134 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D17747917BF10B45

FASTA20724,827
        10         20         30         40         50         60 
MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF TAEGGIRIQK 

        70         80         90        100        110        120 
EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK NIKDIVESFE NEKVAREFLV 

       130        140        150        160        170        180 
RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI LRELYENNYI DEIPKTLSRR KYLEIENILR 

       190        200 
DIGEEVNLKL SELDLYIWYL RTGKVLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98720.1.
PIRD64390.
RefSeqNP_247709.1. NC_000909.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortalQ58134.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0724.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98720; AAB98720; MJ_0724.
GeneID1451601.
KEGGmja:MJ_0724.

Phylogenomic databases

eggNOGCOG1059.
KOK03653.
OMALDLYLWY.
PhylomeDBQ58134.

Family and domain databases

Gene3D1.10.340.30. 1 hit.
HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ58134.

Entry information

Entry nameOGG1_METJA
AccessionPrimary (citable) accession number: Q58134
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names