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Q58134

- OGG1_METJA

UniProt

Q58134 - OGG1_METJA

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Protein

N-glycosylase/DNA lyase

Gene

ogg

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

pH dependencei

Optimum pH is 8.5.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:MJ0724
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi129 – 1291K → S: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207N-glycosylase/DNA lyasePRO_0000159562Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0724.

Structurei

Secondary structure

207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1111Combined sources
Helixi15 – 2713Combined sources
Helixi28 – 314Combined sources
Helixi34 – 4714Combined sources
Helixi52 – 6211Combined sources
Helixi65 – 684Combined sources
Helixi71 – 8010Combined sources
Helixi86 – 9611Combined sources
Helixi97 – 993Combined sources
Helixi102 – 1087Combined sources
Beta strandi109 – 1113Combined sources
Helixi112 – 12211Combined sources
Helixi128 – 13710Combined sources
Helixi148 – 1569Combined sources
Beta strandi159 – 1624Combined sources
Helixi169 – 18517Combined sources
Helixi190 – 20213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortaliQ58134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58134.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiCOG1059.
InParanoidiQ58134.
KOiK03653.
OMAiLDLYLWY.
PhylomeDBiQ58134.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF
60 70 80 90 100
TAEGGIRIQK EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK
110 120 130 140 150
NIKDIVESFE NEKVAREFLV RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI
160 170 180 190 200
LRELYENNYI DEIPKTLSRR KYLEIENILR DIGEEVNLKL SELDLYIWYL

RTGKVLK
Length:207
Mass (Da):24,827
Last modified:November 1, 1996 - v1
Checksum:iD17747917BF10B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1.
PIRiD64390.
RefSeqiNP_247709.1. NC_000909.1.
WP_010870229.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98720; AAB98720; MJ_0724.
GeneIDi1451601.
KEGGimja:MJ_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1 .
PIRi D64390.
RefSeqi NP_247709.1. NC_000909.1.
WP_010870229.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FHF X-ray 2.00 A 1-207 [» ]
3KNT X-ray 2.70 A/B/C/D 1-207 [» ]
ProteinModelPortali Q58134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98720 ; AAB98720 ; MJ_0724 .
GeneIDi 1451601.
KEGGi mja:MJ_0724.

Phylogenomic databases

eggNOGi COG1059.
InParanoidi Q58134.
KOi K03653.
OMAi LDLYLWY.
PhylomeDBi Q58134.

Miscellaneous databases

EvolutionaryTracei Q58134.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii."
    Gogos A., Clarke N.D.
    J. Biol. Chem. 274:30447-30450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF LYS-129.

Entry informationi

Entry nameiOGG1_METJA
AccessioniPrimary (citable) accession number: Q58134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3