Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-glycosylase/DNA lyase

Gene

ogg

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

pH dependencei

Optimum pH is 8.5.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1291

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.B5. 3260.
4.2.99.18. 3260.

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:MJ0724
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129K → S: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595621 – 207N-glycosylase/DNA lyaseAdd BLAST207

Proteomic databases

PRIDEiQ58134.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0724.

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 11Combined sources11
Helixi15 – 27Combined sources13
Helixi28 – 31Combined sources4
Helixi34 – 47Combined sources14
Helixi52 – 62Combined sources11
Helixi65 – 68Combined sources4
Helixi71 – 80Combined sources10
Helixi86 – 96Combined sources11
Helixi97 – 99Combined sources3
Helixi102 – 108Combined sources7
Beta strandi109 – 111Combined sources3
Helixi112 – 122Combined sources11
Helixi128 – 137Combined sources10
Helixi148 – 156Combined sources9
Beta strandi159 – 162Combined sources4
Helixi169 – 185Combined sources17
Helixi190 – 202Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortaliQ58134.
SMRiQ58134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58134.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
InParanoidiQ58134.
KOiK03653.
OMAiELCFCIL.
PhylomeDBiQ58134.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF
60 70 80 90 100
TAEGGIRIQK EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK
110 120 130 140 150
NIKDIVESFE NEKVAREFLV RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI
160 170 180 190 200
LRELYENNYI DEIPKTLSRR KYLEIENILR DIGEEVNLKL SELDLYIWYL

RTGKVLK
Length:207
Mass (Da):24,827
Last modified:November 1, 1996 - v1
Checksum:iD17747917BF10B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1.
PIRiD64390.

Genome annotation databases

EnsemblBacteriaiAAB98720; AAB98720; MJ_0724.
KEGGimja:MJ_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1.
PIRiD64390.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortaliQ58134.
SMRiQ58134.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0724.

Proteomic databases

PRIDEiQ58134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98720; AAB98720; MJ_0724.
KEGGimja:MJ_0724.

Phylogenomic databases

eggNOGiarCOG04357. Archaea.
COG1059. LUCA.
InParanoidiQ58134.
KOiK03653.
OMAiELCFCIL.
PhylomeDBiQ58134.

Enzyme and pathway databases

BRENDAi3.2.2.B5. 3260.
4.2.99.18. 3260.

Miscellaneous databases

EvolutionaryTraceiQ58134.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOGG1_METJA
AccessioniPrimary (citable) accession number: Q58134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.