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Q58134

- OGG1_METJA

UniProt

Q58134 - OGG1_METJA

Protein

N-glycosylase/DNA lyase

Gene

ogg

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG.

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

    pH dependencei

    Optimum pH is 8.5.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-glycosylase/DNA lyase
    Including the following 2 domains:
    8-oxoguanine DNA glycosylase (EC:3.2.2.-)
    DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
    Short name:
    AP lyase
    Gene namesi
    Name:ogg
    Ordered Locus Names:MJ0724
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi129 – 1291K → S: Loss of activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207N-glycosylase/DNA lyasePRO_0000159562Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0724.

    Structurei

    Secondary structure

    207
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1 – 1111
    Helixi15 – 2713
    Helixi28 – 314
    Helixi34 – 4714
    Helixi52 – 6211
    Helixi65 – 684
    Helixi71 – 8010
    Helixi86 – 9611
    Helixi97 – 993
    Helixi102 – 1087
    Beta strandi109 – 1113
    Helixi112 – 12211
    Helixi128 – 13710
    Helixi148 – 1569
    Beta strandi159 – 1624
    Helixi169 – 18517
    Helixi190 – 20213

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FHFX-ray2.00A1-207[»]
    3KNTX-ray2.70A/B/C/D1-207[»]
    ProteinModelPortaliQ58134.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ58134.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.Curated

    Phylogenomic databases

    eggNOGiCOG1059.
    KOiK03653.
    OMAiLDLYLWY.
    PhylomeDBiQ58134.

    Family and domain databases

    Gene3Di1.10.340.30. 1 hit.
    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q58134-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF    50
    TAEGGIRIQK EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK 100
    NIKDIVESFE NEKVAREFLV RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI 150
    LRELYENNYI DEIPKTLSRR KYLEIENILR DIGEEVNLKL SELDLYIWYL 200
    RTGKVLK 207
    Length:207
    Mass (Da):24,827
    Last modified:November 1, 1996 - v1
    Checksum:iD17747917BF10B45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98720.1.
    PIRiD64390.
    RefSeqiNP_247709.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98720; AAB98720; MJ_0724.
    GeneIDi1451601.
    KEGGimja:MJ_0724.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98720.1 .
    PIRi D64390.
    RefSeqi NP_247709.1. NC_000909.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FHF X-ray 2.00 A 1-207 [» ]
    3KNT X-ray 2.70 A/B/C/D 1-207 [» ]
    ProteinModelPortali Q58134.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0724.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98720 ; AAB98720 ; MJ_0724 .
    GeneIDi 1451601.
    KEGGi mja:MJ_0724.

    Phylogenomic databases

    eggNOGi COG1059.
    KOi K03653.
    OMAi LDLYLWY.
    PhylomeDBi Q58134.

    Miscellaneous databases

    EvolutionaryTracei Q58134.

    Family and domain databases

    Gene3Di 1.10.340.30. 1 hit.
    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. "Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii."
      Gogos A., Clarke N.D.
      J. Biol. Chem. 274:30447-30450(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF LYS-129.

    Entry informationi

    Entry nameiOGG1_METJA
    AccessioniPrimary (citable) accession number: Q58134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3