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Protein

N-glycosylase/DNA lyase

Gene

ogg

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

pH dependencei

Optimum pH is 8.5.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1291

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.B5 3260
4.2.99.18 3260

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:MJ0724
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129K → S: Loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595621 – 207N-glycosylase/DNA lyaseAdd BLAST207

Proteomic databases

PRIDEiQ58134

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0724

Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 11Combined sources11
Helixi15 – 27Combined sources13
Helixi28 – 31Combined sources4
Helixi34 – 47Combined sources14
Helixi52 – 62Combined sources11
Helixi65 – 68Combined sources4
Helixi71 – 80Combined sources10
Helixi86 – 96Combined sources11
Helixi97 – 99Combined sources3
Helixi102 – 108Combined sources7
Beta strandi109 – 111Combined sources3
Helixi112 – 122Combined sources11
Helixi128 – 137Combined sources10
Helixi148 – 156Combined sources9
Beta strandi159 – 162Combined sources4
Helixi169 – 185Combined sources17
Helixi190 – 202Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortaliQ58134
SMRiQ58134
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58134

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
InParanoidiQ58134
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL
PhylomeDBiQ58134

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

Q58134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF
60 70 80 90 100
TAEGGIRIQK EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK
110 120 130 140 150
NIKDIVESFE NEKVAREFLV RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI
160 170 180 190 200
LRELYENNYI DEIPKTLSRR KYLEIENILR DIGEEVNLKL SELDLYIWYL

RTGKVLK
Length:207
Mass (Da):24,827
Last modified:November 1, 1996 - v1
Checksum:iD17747917BF10B45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98720.1
PIRiD64390

Genome annotation databases

EnsemblBacteriaiAAB98720; AAB98720; MJ_0724
KEGGimja:MJ_0724

Similar proteinsi

Entry informationi

Entry nameiOGG1_METJA
AccessioniPrimary (citable) accession number: Q58134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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