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Q58134

- OGG1_METJA

UniProt

Q58134 - OGG1_METJA

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Protein

N-glycosylase/DNA lyase

Gene
ogg, MJ0724
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites). Has little specificity for the base opposite oxoG.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

pH dependencei

Optimum pH is 8.5.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:MJ0724
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi129 – 1291K → S: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207N-glycosylase/DNA lyaseUniRule annotationPRO_0000159562Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0724.

Structurei

Secondary structure

207
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 1111
Helixi15 – 2713
Helixi28 – 314
Helixi34 – 4714
Helixi52 – 6211
Helixi65 – 684
Helixi71 – 8010
Helixi86 – 9611
Helixi97 – 993
Helixi102 – 1087
Beta strandi109 – 1113
Helixi112 – 12211
Helixi128 – 13710
Helixi148 – 1569
Beta strandi159 – 1624
Helixi169 – 18517
Helixi190 – 20213

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FHFX-ray2.00A1-207[»]
3KNTX-ray2.70A/B/C/D1-207[»]
ProteinModelPortaliQ58134.

Miscellaneous databases

EvolutionaryTraceiQ58134.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
KOiK03653.
OMAiLDLYLWY.
PhylomeDBiQ58134.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58134-1 [UniParc]FASTAAdd to Basket

« Hide

MMLIKKIEEL KNSEIKDIID KRIQEFKSFK NKSNEEWFKE LCFCILTANF    50
TAEGGIRIQK EIGDGFLTLP REELEEKLKN LGHRFYRKRA EYIVLARRFK 100
NIKDIVESFE NEKVAREFLV RNIKGIGYKE ASHFLRNVGY DDVAIIDRHI 150
LRELYENNYI DEIPKTLSRR KYLEIENILR DIGEEVNLKL SELDLYIWYL 200
RTGKVLK 207
Length:207
Mass (Da):24,827
Last modified:November 1, 1996 - v1
Checksum:iD17747917BF10B45
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1.
PIRiD64390.
RefSeqiNP_247709.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98720; AAB98720; MJ_0724.
GeneIDi1451601.
KEGGimja:MJ_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98720.1 .
PIRi D64390.
RefSeqi NP_247709.1. NC_000909.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3FHF X-ray 2.00 A 1-207 [» ]
3KNT X-ray 2.70 A/B/C/D 1-207 [» ]
ProteinModelPortali Q58134.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98720 ; AAB98720 ; MJ_0724 .
GeneIDi 1451601.
KEGGi mja:MJ_0724.

Phylogenomic databases

eggNOGi COG1059.
KOi K03653.
OMAi LDLYLWY.
PhylomeDBi Q58134.

Miscellaneous databases

EvolutionaryTracei Q58134.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
  2. "Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii."
    Gogos A., Clarke N.D.
    J. Biol. Chem. 274:30447-30450(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF LYS-129.

Entry informationi

Entry nameiOGG1_METJA
AccessioniPrimary (citable) accession number: Q58134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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