ID   HMDH_METJA              Reviewed;         405 AA.
AC   Q58116;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 60.
DE   RecName: Full=3-hydroxy-3-methylglutaryl-coenzyme A reductase;
DE            Short=HMG-CoA reductase;
DE            EC=1.1.1.34;
GN   Name=hmgA; OrderedLocusNames=MJ0705;
OS   Methanocaldococcus jannaschii (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=2190;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   MEDLINE=96337999; PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D.,
RA   Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D.,
RA   Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I.,
RA   Overbeek R., Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A.,
RA   Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D.,
RA   Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C.,
RA   Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M.,
RA   Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Converts HMG-CoA to mevalonate (By similarity).
CC   -!- CATALYTIC ACTIVITY: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-
CC       hydroxy-3-methylglutaryl-CoA + 2 NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; mevalonic acid
CC       biosynthesis; (R)-mevalonic acid from acetyl-CoA: step 3/3.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
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DR   EMBL; L77117; AAB98699.1; -; Genomic_DNA.
DR   PIR; A64388; A64388.
DR   RefSeq; NP_247690.1; -.
DR   HSSP; P04035; 1HWI.
DR   GeneID; 1451573; -.
DR   GenomeReviews; L77117_GR; MJ0705.
DR   KEGG; mja:MJ0705; -.
DR   NMPDR; fig|243232.1.peg.727; -.
DR   TIGR; MJ0705; -.
DR   HOGENOM; Q58116; -.
DR   OMA; Q58116; CVAESAI.
DR   BioCyc; MJAN243232:MJ_0705-MON; -.
DR   BRENDA; 1.1.1.34; 256362.
DR   GO; GO:0016021; C:integral to membrane; IEA:InterPro.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH)...; IEA:EC.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002202; HMG_CoA_Rdtase_cat.
DR   InterPro; IPR004554; HMG_CoA_Rdtase_I_cat.
DR   Gene3D; G3DSA:3.90.770.10; HMG-CoA_red; 1.
DR   PANTHER; PTHR10572; HMG-CoA_red; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   TIGRFAMs; TIGR00533; HMG_CoA_R_NADP; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; FALSE_NEG.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    405       3-hydroxy-3-methylglutaryl-coenzyme A
FT                                reductase.
FT                                /FTId=PRO_0000114461.
FT   ACT_SITE    100    100       Charge relay system (By similarity).
FT   ACT_SITE    310    310       Charge relay system (By similarity).
FT   ACT_SITE    400    400       Proton donor (By similarity).
SQ   SEQUENCE   405 AA;  44128 MW;  F8F8E4729A77DFC9 CRC64;
     MENYNDILEK MLNGEIKPYQ LDKMFGSKIA TEIRRKFIEK KVGIEFKHIC NYSIDEEMAM
     KKNIENMIGA IQIPLGFAGP LKINGEYAKG EFYIPLATTE GALVASVNRG CSIITKCGGA
     TVRVIDDKMT RAPCLKTKSV VDAIKVRDWI RENFERIKEV AESTTRHGKL IKIEPILIVG
     RNLYPRFVFK TGDAMGMNMV TIATEKACNF IEGELKKEGI FVKTVAVSGN ACVDKKPSGM
     NLINGRGKSI VAEVFLTEKE VNKYLKTTSQ AIAEVNRLKN YIGSAISNSM GFNAHYANII
     GAIFLATGQD EAHIVEGSLG ITMAEVEDDG LYFSVTLPDV PIGTVGGGTR VETQKECLEM
     LGCYGDNKAL KFAEIVGAAV LAGELSLLGA LAAGHLGKAH QELGR
//