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Protein

(5-formylfuran-3-yl)methyl phosphate transaminase

Gene

mfnC

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transamination reaction between 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) and alanine to produce pyruvate and 5-(aminomethyl)-3-furanmethanol phosphate (F1-P), the precursor for the furan moiety in methanofuran.1 Publication

Catalytic activityi

L-alanine + (5-formylfuran-3-yl)methyl phosphate = pyruvate + 5-(aminomethyl)-3-furanmethanol phosphate.1 Publication

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-1926-MONOMER.
UniPathwayiUPA00080.

Names & Taxonomyi

Protein namesi
Recommended name:
(5-formylfuran-3-yl)methyl phosphate transaminaseCurated (EC:2.6.1.1081 Publication)
Alternative name(s):
4-HFC-P:alanine aminotransferase1 Publication
Gene namesi
Name:mfnC1 Publication
Ordered Locus Names:MJ0684
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370(5-formylfuran-3-yl)methyl phosphate transaminasePRO_0000123859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei222 – 2221N6-(pyridoxal phosphate)lysine1 Publication

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

STRINGi243232.MJ_0684.

Structurei

Secondary structure

1
370
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85Combined sources
Helixi15 – 2612Combined sources
Helixi45 – 5612Combined sources
Helixi69 – 8214Combined sources
Helixi89 – 913Combined sources
Beta strandi92 – 976Combined sources
Helixi98 – 10912Combined sources
Beta strandi115 – 1217Combined sources
Helixi125 – 1328Combined sources
Beta strandi136 – 1405Combined sources
Helixi144 – 1507Combined sources
Beta strandi153 – 16311Combined sources
Turni165 – 1673Combined sources
Helixi173 – 18210Combined sources
Beta strandi184 – 1896Combined sources
Turni191 – 1944Combined sources
Beta strandi196 – 1994Combined sources
Helixi204 – 2063Combined sources
Beta strandi212 – 2209Combined sources
Turni221 – 2255Combined sources
Helixi227 – 2293Combined sources
Beta strandi232 – 2354Combined sources
Helixi238 – 25114Combined sources
Beta strandi253 – 2553Combined sources
Helixi257 – 2637Combined sources
Helixi264 – 2674Combined sources
Helixi269 – 29527Combined sources
Helixi317 – 32812Combined sources
Helixi335 – 3384Combined sources
Helixi340 – 3423Combined sources
Beta strandi343 – 3497Combined sources
Helixi354 – 36815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z61X-ray2.20A1-370[»]
ProteinModelPortaliQ58097.
SMRiQ58097. Positions 1-369.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ58097.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01130. Archaea.
COG0436. LUCA.
InParanoidiQ58097.
KOiK19793.
OMAiLIMREQY.
PhylomeDBiQ58097.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKRLLNFE SFEVMDILAL AQKLESEGKK VIHLEIGEPD FNTPKPIVDE
60 70 80 90 100
GIKSLKEGKT HYTDSRGILE LREKISELYK DKYKADIIPD NIIITGGSSL
110 120 130 140 150
GLFFALSSII DDGDEVLIQN PCYPCYKNFI RFLGAKPVFC DFTVESLEEA
160 170 180 190 200
LSDKTKAIII NSPSNPLGEV IDREIYEFAY ENIPYIISDE IYNGLVYEGK
210 220 230 240 250
CYSAIEFDEN LEKTILINGF SKLYAMTGWR IGYVISNDEI IEAILKLQQN
260 270 280 290 300
LFISAPTISQ YAALKAFEKE TEREINSMIK EFDRRRRLVL KYVKDFGWEV
310 320 330 340 350
NNPIGAYYVF PNIGEDGREF AYKLLKEKFV ALTPGIGFGS KGKNYIRISY
360 370
ANSYENIKEG LERIKEFLNK
Length:370
Mass (Da):42,348
Last modified:December 15, 1998 - v2
Checksum:i51C2EE6D50079940
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98679.1.

Genome annotation databases

EnsemblBacteriaiAAB98679; AAB98679; MJ_0684.
KEGGimja:MJ_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98679.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Z61X-ray2.20A1-370[»]
ProteinModelPortaliQ58097.
SMRiQ58097. Positions 1-369.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98679; AAB98679; MJ_0684.
KEGGimja:MJ_0684.

Phylogenomic databases

eggNOGiarCOG01130. Archaea.
COG0436. LUCA.
InParanoidiQ58097.
KOiK19793.
OMAiLIMREQY.
PhylomeDBiQ58097.

Enzyme and pathway databases

UniPathwayiUPA00080.
BioCyciRETL1328306-WGS:GSTH-1926-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ58097.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFNC_METJA
AccessioniPrimary (citable) accession number: Q58097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.