Q58094 (TKTN_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative transketolase N-terminal section
Short name=TK
EC=2.2.1.1

Gene names

Ordered Locus Names:

MJ0681

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
Cofactor	Binds 1 calcium ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Sequence similarities	Belongs to the transketolase family.
Caution	Could be the product of a pseudogene. Corresponds to the N-terminal of members of this family.

Ontologies

Keywords
Ligand	Calcium Metal-binding Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transketolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Putative transketolase N-terminal section		PRO_0000191914
Sites
	Metal binding	149	1	Calcium By similarity
	Metal binding	179	1	Calcium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q58094 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: FE3C053AC09F0A4E	FASTA	274	30,336
	10 20 30 40 50 60 MDNNLEIKDL EKIAKKVRYN IVKMVGLAKS GHPGGSLSAT DIIVALYFKL MNYSPDNPYK 70 80 90 100 110 120 KDRDRFVLSK GHAAPALYAV LSELGIIEEE ELWKLRRLEG KLQGHPSMDT PGVEICTGSL 130 140 150 160 170 180 GQGFSAAVGM ALGCRLDKLN NYVYVLLGDG ECQEGIVWEA AMAAAHYKLD NLIAFIDRNK 190 200 210 220 230 240 LQIDGCTEDV MSLGDIKAKF EAFGWDVFEI DGHNFEEIIN TVEKAKSMKN GKPKMIIAYT 250 260 270 VKGKGVSFME NNVAFHGKAP NEEQLKQALE ELSE

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98676.1.
PIR	A64385.
RefSeq	NP_247665.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58094.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1451547.
GenomeReviews	Gene locus MJ0681 in contig L77117_GR.
KEGG	mja:MJ_0681.
NMPDR	fig|243232.1.peg.702.
TIGR	MJ0681.
Phylogenomic databases
HOGENOM	HBG670382.
OMA	MANGMAL.
ProtClustDB	CLSK876292.
Enzyme and pathway databases
BioCyc	MJAN243232:MJ_0681-MONOMER.
Family and domain databases
InterPro	IPR005474. Transketolase_N. [Graphical view]
KO	K00615.
Pfam	PF00456. Transketolase_N. 1 hit. [Graphical view]
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TKTN_METJA

Accession

Primary (citable) accession number: Q58094

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program