Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q58081 (AMPPA_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
AMP phosphorylase

Short name=AMPpase
EC=2.4.2.57
Alternative name(s):
Nucleoside monophosphate phosphorylase
Short name=NMP phosphorylase
Gene names
Ordered Locus Names:MJ0667
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity. HAMAP-Rule MF_02132

Catalytic activity

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate. HAMAP-Rule MF_02132

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503AMP phosphorylase HAMAP-Rule MF_02132
PRO_0000059088

Regions

Nucleotide binding194 – 1996AMP By similarity

Sites

Active site2561Proton donor By similarity
Binding site1681AMP; via amide nitrogen By similarity
Binding site2031AMP; via amide nitrogen By similarity
Binding site2641AMP By similarity
Binding site2881AMP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58081 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EFBB97D4A9ADEE18

FASTA50354,722
        10         20         30         40         50         60 
MLFLKVRVLD IDLENLVLIN SEDLKSSQYF PQDRVVVEFK GKEVIGILHS STTLINRGEI 

        70         80         90        100        110        120 
GLPQKVVKEL GVKEGDIVTI KHAEKPKSLP YIRKKMDGNK LKKEEIFEII DEMVDGKLTN 

       130        140        150        160        170        180 
IEISAFVTSL YINGMDMDEI EAMTIRMAET GEMVNWEGHI FDVHSIGGVP GNKYALLVVP 

       190        200        210        220        230        240 
IVASAGLKIP KTSSRAITSA AGTADVVEVL TRVDLTIEEI KRVVKETNGC MVWGGALDLA 

       250        260        270        280        290        300 
PADDITINVE RPLGIDPEPL LLSSVMAKKL AMGVNKLLID IPTGYGAKVK SIKEASSLAR 

       310        320        330        340        350        360 
KFIELSDRLR IVTECAITYG GQPIGRAIGP ALEAKEALLA LEDYTQAPTS LVEKSISLAG 

       370        380        390        400        410        420 
ILLEMGGVAP TGEGKELAED LLARGKAHDK FMEIIVAQGG KEVSSDEIEV GKYKADIHSP 

       430        440        450        460        470        480 
IDGYVTRISN AGITKIAKEA GAPNDKKAGI YLNVKVGNKV EKGDVLYTIY SDSEERLKSA 

       490        500 
IKLARILYPI KVEGMLLQKI SRF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98662.1.
PIRC64383.
RefSeqNP_247651.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58081.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98662; AAB98662; MJ_0667.
GeneID1451533.
KEGGmja:MJ_0667.

Phylogenomic databases

eggNOGCOG0213.
KOK00758.
OMAESVPGFH.
PhylomeDBQ58081.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_02132. AMP_phosphorylase.
InterProIPR017713. AMP_phosphorylase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPPA_METJA
AccessionPrimary (citable) accession number: Q58081
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names