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Q58065 (NAOX_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative NADH oxidase

Short name=NOXase
EC=1.6.99.3
Gene names
Ordered Locus Names:MJ0649
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the four-electron reduction of molecular oxygen to water By similarity.

Catalytic activity

NADH + acceptor = NAD+ + reduced acceptor.

Cofactor

Binds 1 FAD per subunit By similarity.

Sequence similarities

Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

Sequence caution

The sequence AAB98641.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainRedox-active center
   LigandFAD
Flavoprotein
NAD
   Molecular functionOxidoreductase
   PTMOxidation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionNADH dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Putative NADH oxidase
PRO_0000184704

Regions

Nucleotide binding7 – 115FAD By similarity
Nucleotide binding110 – 1134FAD By similarity
Nucleotide binding152 – 16716NAD By similarity
Nucleotide binding271 – 28111FAD By similarity

Sites

Active site421Redox-active
Binding site421FAD By similarity
Binding site1321FAD By similarity
Binding site2431NAD; via amide nitrogen By similarity

Amino acid modifications

Modified residue421Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58065 [UniParc].

Last modified March 1, 2005. Version 2.
Checksum: 8790664DF98D9DCD

FASTA44848,876
        10         20         30         40         50         60 
MRAIIIGSGA AGLTTASTIR KYNKDMEIVV ITKEKEIAYS PCAIPYVIEG AIKSFDDIIM 

        70         80         90        100        110        120 
HTPEDYKRER NIDILTETTV IDVDSKNNKI KCVDKDGNEF EMNYDYLVLA TGAEPFIPPI 

       130        140        150        160        170        180 
EGKDLDGVFK VRTIEDGRAI LKYIEENGCK KVAVVGAGAI GLEMAYGLKC RGLDVLVVEM 

       190        200        210        220        230        240 
APQVLPRFLD PDMAEIVQKY LEKEGIKVML SKPLEKIVGK EKVEAVYVDG KLYDVDMVIM 

       250        260        270        280        290        300 
ATGVRPNIEL AKKAGCKIGK FAIEVNEKMQ TSIPNIYAVG DCVEVIDFIT GEKTLSPFGT 

       310        320        330        340        350        360 
AAVRQGKVAG KNIAGVEAKF YPVLNSAVSK IGDLEIGGTG LTAFSANLKR IPIVIGRAKA 

       370        380        390        400        410        420 
LTRARYYPGG KEIEIKMIFN EDGKVVGCQI VGGERVAERI DAMSIAIFKK VSAEELANME 

       430        440 
FCYAPPVSMV HEPLSLAAED ALKKLSNK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L77117 Genomic DNA. Translation: AAB98641.1. Different initiation.
PIRA64381.
RefSeqNP_247633.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58065.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243232.MJ0649.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98641; AAB98641; MJ_0649.
GeneID1451515.
KEGGmja:MJ_0649.

Phylogenomic databases

eggNOGCOG0446.
KOK17870.
OMAELANMEF.
PhylomeDBQ58065.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAOX_METJA
AccessionPrimary (citable) accession number: Q58065
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names