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Q58065

- NAOX_METJA

UniProt

Q58065 - NAOX_METJA

Protein

Putative NADH oxidase

Gene

MJ0649

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the four-electron reduction of molecular oxygen to water.By similarity

    Catalytic activityi

    NADH + acceptor = NAD+ + reduced acceptor.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421Redox-active
    Binding sitei42 – 421FADBy similarity
    Binding sitei132 – 1321FADBy similarity
    Binding sitei243 – 2431NAD; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 115FADBy similarity
    Nucleotide bindingi110 – 1134FADBy similarity
    Nucleotide bindingi152 – 16716NADBy similarityAdd
    BLAST
    Nucleotide bindingi271 – 28111FADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. NADH dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative NADH oxidase (EC:1.6.99.3)
    Short name:
    NOXase
    Gene namesi
    Ordered Locus Names:MJ0649
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Putative NADH oxidasePRO_0000184704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421Cysteine sulfenic acid (-SOH)By similarity

    Keywords - PTMi

    Oxidation

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0649.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58065.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0446.
    KOiK17870.
    OMAiELANMEF.
    PhylomeDBiQ58065.

    Family and domain databases

    Gene3Di3.30.390.30. 1 hit.
    InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view]
    PfamiPF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    SUPFAMiSSF55424. SSF55424. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q58065-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAIIIGSGA AGLTTASTIR KYNKDMEIVV ITKEKEIAYS PCAIPYVIEG    50
    AIKSFDDIIM HTPEDYKRER NIDILTETTV IDVDSKNNKI KCVDKDGNEF 100
    EMNYDYLVLA TGAEPFIPPI EGKDLDGVFK VRTIEDGRAI LKYIEENGCK 150
    KVAVVGAGAI GLEMAYGLKC RGLDVLVVEM APQVLPRFLD PDMAEIVQKY 200
    LEKEGIKVML SKPLEKIVGK EKVEAVYVDG KLYDVDMVIM ATGVRPNIEL 250
    AKKAGCKIGK FAIEVNEKMQ TSIPNIYAVG DCVEVIDFIT GEKTLSPFGT 300
    AAVRQGKVAG KNIAGVEAKF YPVLNSAVSK IGDLEIGGTG LTAFSANLKR 350
    IPIVIGRAKA LTRARYYPGG KEIEIKMIFN EDGKVVGCQI VGGERVAERI 400
    DAMSIAIFKK VSAEELANME FCYAPPVSMV HEPLSLAAED ALKKLSNK 448
    Length:448
    Mass (Da):48,876
    Last modified:March 1, 2005 - v2
    Checksum:i8790664DF98D9DCD
    GO

    Sequence cautioni

    The sequence AAB98641.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98641.1. Different initiation.
    PIRiA64381.
    RefSeqiNP_247633.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98641; AAB98641; MJ_0649.
    GeneIDi1451515.
    KEGGimja:MJ_0649.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98641.1 . Different initiation.
    PIRi A64381.
    RefSeqi NP_247633.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58065.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0649.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98641 ; AAB98641 ; MJ_0649 .
    GeneIDi 1451515.
    KEGGi mja:MJ_0649.

    Phylogenomic databases

    eggNOGi COG0446.
    KOi K17870.
    OMAi ELANMEF.
    PhylomeDBi Q58065.

    Family and domain databases

    Gene3Di 3.30.390.30. 1 hit.
    InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
    IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR001327. Pyr_OxRdtase_NAD-bd_dom.
    [Graphical view ]
    Pfami PF00070. Pyr_redox. 1 hit.
    PF07992. Pyr_redox_2. 1 hit.
    PF02852. Pyr_redox_dim. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    SUPFAMi SSF55424. SSF55424. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiNAOX_METJA
    AccessioniPrimary (citable) accession number: Q58065
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3