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Q58065

- NAOX_METJA

UniProt

Q58065 - NAOX_METJA

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Protein

Putative NADH oxidase

Gene

MJ0649

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the four-electron reduction of molecular oxygen to water.By similarity

Catalytic activityi

NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Redox-active
Binding sitei42 – 421FADBy similarity
Binding sitei132 – 1321FADBy similarity
Binding sitei243 – 2431NAD; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 115FADBy similarity
Nucleotide bindingi110 – 1134FADBy similarity
Nucleotide bindingi152 – 16716NADBy similarityAdd
BLAST
Nucleotide bindingi271 – 28111FADBy similarityAdd
BLAST

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. NADH dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative NADH oxidase (EC:1.6.99.3)
Short name:
NOXase
Gene namesi
Ordered Locus Names:MJ0649
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Putative NADH oxidasePRO_0000184704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421Cysteine sulfenic acid (-SOH)By similarity

Keywords - PTMi

Oxidation

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0649.

Structurei

3D structure databases

ProteinModelPortaliQ58065.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0446.
InParanoidiQ58065.
KOiK17870.
OMAiELANMEF.
PhylomeDBiQ58065.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
InterProiIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamiPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
SUPFAMiSSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

Q58065-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAIIIGSGA AGLTTASTIR KYNKDMEIVV ITKEKEIAYS PCAIPYVIEG
60 70 80 90 100
AIKSFDDIIM HTPEDYKRER NIDILTETTV IDVDSKNNKI KCVDKDGNEF
110 120 130 140 150
EMNYDYLVLA TGAEPFIPPI EGKDLDGVFK VRTIEDGRAI LKYIEENGCK
160 170 180 190 200
KVAVVGAGAI GLEMAYGLKC RGLDVLVVEM APQVLPRFLD PDMAEIVQKY
210 220 230 240 250
LEKEGIKVML SKPLEKIVGK EKVEAVYVDG KLYDVDMVIM ATGVRPNIEL
260 270 280 290 300
AKKAGCKIGK FAIEVNEKMQ TSIPNIYAVG DCVEVIDFIT GEKTLSPFGT
310 320 330 340 350
AAVRQGKVAG KNIAGVEAKF YPVLNSAVSK IGDLEIGGTG LTAFSANLKR
360 370 380 390 400
IPIVIGRAKA LTRARYYPGG KEIEIKMIFN EDGKVVGCQI VGGERVAERI
410 420 430 440
DAMSIAIFKK VSAEELANME FCYAPPVSMV HEPLSLAAED ALKKLSNK
Length:448
Mass (Da):48,876
Last modified:March 1, 2005 - v2
Checksum:i8790664DF98D9DCD
GO

Sequence cautioni

The sequence AAB98641.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98641.1. Different initiation.
PIRiA64381.
RefSeqiNP_247633.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98641; AAB98641; MJ_0649.
GeneIDi1451515.
KEGGimja:MJ_0649.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L77117 Genomic DNA. Translation: AAB98641.1 . Different initiation.
PIRi A64381.
RefSeqi NP_247633.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58065.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98641 ; AAB98641 ; MJ_0649 .
GeneIDi 1451515.
KEGGi mja:MJ_0649.

Phylogenomic databases

eggNOGi COG0446.
InParanoidi Q58065.
KOi K17870.
OMAi ELANMEF.
PhylomeDBi Q58065.

Family and domain databases

Gene3Di 3.30.390.30. 1 hit.
InterProi IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view ]
Pfami PF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
SUPFAMi SSF55424. SSF55424. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiNAOX_METJA
AccessioniPrimary (citable) accession number: Q58065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3