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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei636ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MJ0633
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521311 – 942Leucine--tRNA ligaseAdd BLAST942

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ_0633

Structurei

3D structure databases

ProteinModelPortaliQ58050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi633 – 637"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
InParanoidiQ58050
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D
PhylomeDBiQ58050

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q58050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVMIDFKEI EKKWQKRWEE AKIFEANPDD REKFFITAAF PYLNGVLHAG
60 70 80 90 100
HLRTFTIPEV VARFQRMKNK NVLWTFGYHV TGTPILGLAE LIKNRDEKTI
110 120 130 140 150
WAYTELHGIP KEELLELTTP EKIVEYFSKK AEEAFKRMGF SLDWRRNFKT
160 170 180 190 200
DDKVFNKFIE WQFHKLKEKG LIVKGSHPVR YCPRCDNPVE DHDILVGENA
210 220 230 240 250
TLVEYILIKF TTEDGCIMPM ATLRPETVFG VTNVWVNPEA TYVKAKVYLE
260 270 280 290 300
KETENGIELI ENGIWIMAKE CAEKLKHQDR KIEIIEEFKG EQLINKKVKN
310 320 330 340 350
PVTGKEVPIL PAKFVKTNIG TGCVMSVPAH APYDYIALRD LGLVDEIGLI
360 370 380 390 400
PLINVPGYGK YPAKEIVEKM GIKSQEEEDK LEEATKKIYK DEFHKGVLNE
410 420 430 440 450
NCLDYEGIPV REIKDKLTKD LIDKGLAEIM YEFSEEKVIC RCGTPCIVKM
460 470 480 490 500
VKGQWFIKYS DEKWKELAHK CIDKMRFIPE NLRQVFHEKI DWMKDKACVR
510 520 530 540 550
RRGLGTKFPF EEGWVIESLS DSTIYPAYYT VAKYINQHNI KPEQLTLELF
560 570 580 590 600
DYVFLGKGDV DKIAKETGIP KDIIEGMRKE FIYYYPVDWR CSAKDLIPNH
610 620 630 640 650
LTFYIFNHVA IFPEEFWPRG IVVNGYVTIE GKKLSKSKGP VLPVLEVAEK
660 670 680 690 700
FGADVGRFYI TTCAELPQDA DIKFKEMENT KKVLERLYLF AKEIAERRGE
710 720 730 740 750
TGEEFSYIDK WLLSRLYKAV KQYDEYMENF ELRKAGILLY QLLDDLKWYR
760 770 780 790 800
RRGGNNIRVL EEFLEVIIKL MMPFTPHLCE EMWEILGKEG FVSLAKFPEV
810 820 830 840 850
KEEFINDEIE KGEEYLKAVM EDIKEIINVA KVQPKRIYLY TADDWKYEIL
860 870 880 890 900
KIIKENEGKT IKELMPIIMK NPEFRKYGKE IPKLVNQLIK LNAEIINEVE
910 920 930 940
VLENAKEFLK KEVGVEDIII NGEDKANKKR VAIPFKPAIY LE
Length:942
Mass (Da):110,184
Last modified:December 15, 1998 - v2
Checksum:i25A551461566A399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98628.1
PIRiA64379

Genome annotation databases

EnsemblBacteriaiAAB98628; AAB98628; MJ_0633
KEGGimja:MJ_0633

Similar proteinsi

Entry informationi

Entry nameiSYL_METJA
AccessioniPrimary (citable) accession number: Q58050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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