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Q58050

- SYL_METJA

UniProt

Q58050 - SYL_METJA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei636 – 6361ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MJ0633
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Leucine--tRNA ligasePRO_0000152131Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0633.

Structurei

3D structure databases

ProteinModelPortaliQ58050.
SMRiQ58050. Positions 5-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi633 – 6375"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
InParanoidiQ58050.
KOiK01869.
OMAiHAPFDYL.
PhylomeDBiQ58050.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58050-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMVMIDFKEI EKKWQKRWEE AKIFEANPDD REKFFITAAF PYLNGVLHAG
60 70 80 90 100
HLRTFTIPEV VARFQRMKNK NVLWTFGYHV TGTPILGLAE LIKNRDEKTI
110 120 130 140 150
WAYTELHGIP KEELLELTTP EKIVEYFSKK AEEAFKRMGF SLDWRRNFKT
160 170 180 190 200
DDKVFNKFIE WQFHKLKEKG LIVKGSHPVR YCPRCDNPVE DHDILVGENA
210 220 230 240 250
TLVEYILIKF TTEDGCIMPM ATLRPETVFG VTNVWVNPEA TYVKAKVYLE
260 270 280 290 300
KETENGIELI ENGIWIMAKE CAEKLKHQDR KIEIIEEFKG EQLINKKVKN
310 320 330 340 350
PVTGKEVPIL PAKFVKTNIG TGCVMSVPAH APYDYIALRD LGLVDEIGLI
360 370 380 390 400
PLINVPGYGK YPAKEIVEKM GIKSQEEEDK LEEATKKIYK DEFHKGVLNE
410 420 430 440 450
NCLDYEGIPV REIKDKLTKD LIDKGLAEIM YEFSEEKVIC RCGTPCIVKM
460 470 480 490 500
VKGQWFIKYS DEKWKELAHK CIDKMRFIPE NLRQVFHEKI DWMKDKACVR
510 520 530 540 550
RRGLGTKFPF EEGWVIESLS DSTIYPAYYT VAKYINQHNI KPEQLTLELF
560 570 580 590 600
DYVFLGKGDV DKIAKETGIP KDIIEGMRKE FIYYYPVDWR CSAKDLIPNH
610 620 630 640 650
LTFYIFNHVA IFPEEFWPRG IVVNGYVTIE GKKLSKSKGP VLPVLEVAEK
660 670 680 690 700
FGADVGRFYI TTCAELPQDA DIKFKEMENT KKVLERLYLF AKEIAERRGE
710 720 730 740 750
TGEEFSYIDK WLLSRLYKAV KQYDEYMENF ELRKAGILLY QLLDDLKWYR
760 770 780 790 800
RRGGNNIRVL EEFLEVIIKL MMPFTPHLCE EMWEILGKEG FVSLAKFPEV
810 820 830 840 850
KEEFINDEIE KGEEYLKAVM EDIKEIINVA KVQPKRIYLY TADDWKYEIL
860 870 880 890 900
KIIKENEGKT IKELMPIIMK NPEFRKYGKE IPKLVNQLIK LNAEIINEVE
910 920 930 940
VLENAKEFLK KEVGVEDIII NGEDKANKKR VAIPFKPAIY LE
Length:942
Mass (Da):110,184
Last modified:December 15, 1998 - v2
Checksum:i25A551461566A399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98628.1.
PIRiA64379.
RefSeqiNP_247617.1. NC_000909.1.
WP_010870138.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98628; AAB98628; MJ_0633.
GeneIDi1451499.
KEGGimja:MJ_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98628.1 .
PIRi A64379.
RefSeqi NP_247617.1. NC_000909.1.
WP_010870138.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58050.
SMRi Q58050. Positions 5-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0633.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98628 ; AAB98628 ; MJ_0633 .
GeneIDi 1451499.
KEGGi mja:MJ_0633.

Phylogenomic databases

eggNOGi COG0495.
InParanoidi Q58050.
KOi K01869.
OMAi HAPFDYL.
PhylomeDBi Q58050.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiSYL_METJA
AccessioniPrimary (citable) accession number: Q58050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3