Q58034 (FUMB_METJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative fumarate hydratase subunit beta
Short name=Fumarase
EC=4.2.1.2

Gene names

Ordered Locus Names:

MJ0617

Organism

Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]

Taxonomic identifier

243232 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus jannaschii

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate = fumarate + H2O.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
Sequence similarities	Belongs to the class-I fumarase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	fumarate hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Putative fumarate hydratase subunit beta		PRO_0000195662
Sites
	Active site	36	1	Potential
	Binding site	104	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q58034 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A5FDEB0E77D00902	FASTA	195	21,868
	10 20 30 40 50 60 MEYTFNKLTK KDVKKLKVGD IVYLNGKIYT ARDEAHLKII EMLKSNEKLP FDLNESIIYH 70 80 90 100 110 120 AGPIMKKVND SWVCVSIGPT TSARMNDVEE EFIKLTNISA IVGKGGMKKE LLKTFEDYGV 130 140 150 160 170 180 VYLAAPGGCA ALLANSVKRV DNVYFLDELG MPEAVWELEV NNFGPLIVAM DSHGNSIYEE 190 VNKKVYEKLN ELIGL

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98612.1.
PIR	A64377.
RefSeq	NP_247601.1. NC_000909.1.
3D structure databases
ProteinModelPortal	Q58034.
ModBase	Search...
Protein-protein interaction databases
STRING	243232.MJ0617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB98612; AAB98612; MJ_0617.
GeneID	1451483.
KEGG	mja:MJ_0617.
Phylogenomic databases
eggNOG	COG1838.
KO	K01678.
OMA	VIYHAGP.
ProtClustDB	CLSK876266.
Enzyme and pathway databases
UniPathway	UPA00223; UER01007.
Family and domain databases
Gene3D	3.20.130.10. 1 hit.
InterPro	IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat. [Graphical view]
Pfam	PF05683. Fumerase_C. 1 hit. [Graphical view]
SUPFAM	SSF117457. SSF117457. 1 hit.
TIGRFAMs	TIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUMB_METJA

Accession

Primary (citable) accession number: Q58034

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program