Reviewed, UniProtKB/Swiss-Prot Q58034 (FUMB_METJA)

Names and origin

Protein names

Recommended name:
    Putative fumarate hydratase subunit beta
      Short name=Fumarase
    EC=4.2.1.2

Gene names

Ordered Locus Names:

MJ0617

Organism

Methanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]

Taxonomic identifier

2190 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-malate = fumarate + H2O.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.
Sequence similarities	Belongs to the class-I fumarase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fumarate hydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Putative fumarate hydratase subunit beta		PRO_0000195662
Sites
	Active site	36	1	Potential
	Binding site	104	1	Substrate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q58034-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A5FDEB0E77D00902	FASTA	195	21,868
	10 20 30 40 50 60 MEYTFNKLTK KDVKKLKVGD IVYLNGKIYT ARDEAHLKII EMLKSNEKLP FDLNESIIYH 70 80 90 100 110 120 AGPIMKKVND SWVCVSIGPT TSARMNDVEE EFIKLTNISA IVGKGGMKKE LLKTFEDYGV 130 140 150 160 170 180 VYLAAPGGCA ALLANSVKRV DNVYFLDELG MPEAVWELEV NNFGPLIVAM DSHGNSIYEE 190 VNKKVYEKLN ELIGL

References

[1]

"Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii." Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G., Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R., Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R., Kirkness E.F., Weinstock K.G. , Merrick J.M., Glodek A., Scott J.L., Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R., Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D., Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Science 273:1058-1073(1996) [PubMed: 8688087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L77117 Genomic DNA. Translation: AAB98612.1.
PIR	A64377.
RefSeq	NP_247601.1.
3D structure databases
SMR	Q58034. Positions 1-180.
ModBase	Search...
Genome annotation databases
GeneID	1451483.
GenomeReviews	Gene locus MJ0617 in contig L77117_GR.
KEGG	mja:MJ0617.
NMPDR	fig|243232.1.peg.638.
TIGR	MJ0617.
Phylogenomic databases
HOGENOM	HBG655206.
OMA	GVIYHAG.
Enzyme and pathway databases
BRENDA	4.2.1.2. 256362.
Family and domain databases
InterPro	IPR004647. Fe-S_hydro-lyase_TtdB-typ_cat. [Graphical view]
Gene3D	G3DSA:3.20.130.10. TtdB_fumA_fumB. 1 hit.
Pfam	PF05683. Fumerase_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00723. ttdB_fumA_fumB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUMB_METJA

Accession

Primary (citable) accession number: Q58034

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)