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Q58017

- T2M3_METJA

UniProt

Q58017 - T2M3_METJA

Protein

Type-2 restriction enzyme MjaIII

Gene

mjaIIIR

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Recognizes the double-stranded unmethylated sequence GATC and cleaves before G-1.

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Restriction system

    Protein family/group databases

    REBASEi3891. MjaIII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 restriction enzyme MjaIII (EC:3.1.21.4)
    Short name:
    R.MjaIII
    Alternative name(s):
    Endonuclease MjaIII
    Type II restriction enzyme MjaIII
    Gene namesi
    Name:mjaIIIR
    Ordered Locus Names:MJ0600
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Type-2 restriction enzyme MjaIIIPRO_0000077334Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58017.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG12396.
    KOiK01155.
    OMAiTNYYGGG.

    Family and domain databases

    InterProiIPR021191. Restrct_endonuc_II_DpmII.
    IPR007637. Restrct_endonuc_II_DpmII-like.
    [Graphical view]
    PfamiPF04556. DpnII. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016080. Restrict_endonuc_II_DpmII. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q58017-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFEYIINSL LETIKTYNFF VDWEKIENNI KKIEKRLHIL NYLIGKENFK    50
    EEFFELLKEY PEVITVFPIL IAVRDNKITI LNENMELETL EFKEKKYLTD 100
    EEIERYYKFF KETGLEDLLK NRKIKNLVDY VFGVEVGMDT NARKNRIGDL 150
    MENIVKKYIE NLCKQNKNLD YIFQATKDKI KQKWGINLTL DKTNRKFDFA 200
    VFNKNTKKLY LIEVNFYSGG GSKLKATAGE YRSLNEFIKN NNNNVQFIWI 250
    TDGKGWNTAK NPLKESFNSG VVILNLKMVK EGLLKEILTQ 290
    Length:290
    Mass (Da):34,392
    Last modified:November 1, 1996 - v1
    Checksum:iACEBAE31B029900D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98591.1.
    PIRiH64374.
    RefSeqiNP_247582.1. NC_000909.1.
    WP_010870104.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98591; AAB98591; MJ_0600.
    GeneIDi1451465.
    KEGGimja:MJ_0600.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98591.1 .
    PIRi H64374.
    RefSeqi NP_247582.1. NC_000909.1.
    WP_010870104.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58017.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0600.

    Protein family/group databases

    REBASEi 3891. MjaIII.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98591 ; AAB98591 ; MJ_0600 .
    GeneIDi 1451465.
    KEGGi mja:MJ_0600.

    Phylogenomic databases

    eggNOGi NOG12396.
    KOi K01155.
    OMAi TNYYGGG.

    Family and domain databases

    InterProi IPR021191. Restrct_endonuc_II_DpmII.
    IPR007637. Restrct_endonuc_II_DpmII-like.
    [Graphical view ]
    Pfami PF04556. DpnII. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016080. Restrict_endonuc_II_DpmII. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.
    2. Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiT2M3_METJA
    AccessioniPrimary (citable) accession number: Q58017
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3