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Reviewed, UniProtKB/Swiss-Prot Q58015 (MTM3_METJA)

Last modified November 3, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Modification methylase MjaIII
      Short name=M.MjaIII
    EC=2.1.1.72
Alternative name(s):
    Adenine-specific methyltransferase MjaIII
Gene names
Name: mjaIIIM
Ordered Locus Names: MJ0598
OrganismMethanocaldococcus jannaschii (Methanococcus jannaschii) [Complete proteome] [HAMAP]
Taxonomic identifier2190 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease Potential.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Modification methylase MjaIII
PRO_0000087976

Sites

Binding site91S-adenosyl-L-methionine By similarity
Binding site131S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site631S-adenosyl-L-methionine By similarity
Binding site1991S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58015-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CA95493C5CED8E78

FASTA28934,235
        10         20         30         40         50         60 
MEVKPFLKWA GGKTQILSQI EENLPKELKE GNIKKYIEPF VGGGAVLFYL LQKYEFKKVI 

        70         80         90        100        110        120 
ISDINEDLML CYKVVKNDVD RLIEELSSLR DEFLSLDEEK RKEFYYKVRD DFNKNKNDCD 

       130        140        150        160        170        180 
EVKRVAQFIF LNKTCYNGLY RVNKKGEFNV PYGRYKNPKI FDEQNLKNVS KLLKNVKILC 

       190        200        210        220        230        240 
GDFEIVDEYV DAESFVYFDP PYKPLNKTSS FTSYTKYDFN DDDQIRLAKF YRKLDKRGAK 

       250        260        270        280 
LMLSNSYNVD FFGKLYEGFN IKKVVAKRMI NCKGDKRKDG IYELLIMNY 

« Hide

Cross-references

Sequence databases

L77117 Genomic DNA. Translation: AAB98590.1.
PIRF64374.
RefSeqNP_247580.1.

3D structure databases

HSSPHSSP built from PDB template 2DPM based on UniProtKB P04043.
ModBaseSearch...

Genome annotation databases

GeneID1451463.
GenomeReviewsGene locus MJ0598 in contig L77117_GR.
KEGGmja:MJ0598.
NMPDRfig|243232.1.peg.617.
TIGRMJ0598.

Phylogenomic databases

HOGENOMQ58015.
OMAWAGGKFR.

Enzyme and pathway databases

BioCycMJAN243232:MJ_0598-MON.
BRENDA2.1.1.72. 256362.

Family and domain databases

InterProIPR002294. D12N6_MeTrfase.
IPR012326. Dam.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012327. MeTrfase_D12.
[Graphical view]
PfamPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PRINTSPR00505. D12N6MTFRASE.
TIGRFAMsTIGR00571. dam. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTM3_METJA
AccessionPrimary (citable) accession number: Q58015
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents