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Q58015

- MTM3_METJA

UniProt

Q58015 - MTM3_METJA

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Protein

Modification methylase MjaIII

Gene

mjaIIIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease.Curated

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91S-adenosyl-L-methionineBy similarity
Binding sitei13 – 131S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei63 – 631S-adenosyl-L-methionineBy similarity
Binding sitei199 – 1991S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3890. M.MjaIII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MjaIII (EC:2.1.1.72)
Short name:
M.MjaIII
Alternative name(s):
Adenine-specific methyltransferase MjaIII
Gene namesi
Name:mjaIIIM
Ordered Locus Names:MJ0598
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000000805: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Modification methylase MjaIIIPRO_0000087976Add
BLAST

Proteomic databases

PRIDEiQ58015.

Interactioni

Protein-protein interaction databases

STRINGi243232.MJ0598.

Structurei

3D structure databases

ProteinModelPortaliQ58015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0338.
InParanoidiQ58015.
KOiK06223.
OMAiKFTREIY.
PhylomeDBiQ58015.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q58015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVKPFLKWA GGKTQILSQI EENLPKELKE GNIKKYIEPF VGGGAVLFYL
60 70 80 90 100
LQKYEFKKVI ISDINEDLML CYKVVKNDVD RLIEELSSLR DEFLSLDEEK
110 120 130 140 150
RKEFYYKVRD DFNKNKNDCD EVKRVAQFIF LNKTCYNGLY RVNKKGEFNV
160 170 180 190 200
PYGRYKNPKI FDEQNLKNVS KLLKNVKILC GDFEIVDEYV DAESFVYFDP
210 220 230 240 250
PYKPLNKTSS FTSYTKYDFN DDDQIRLAKF YRKLDKRGAK LMLSNSYNVD
260 270 280
FFGKLYEGFN IKKVVAKRMI NCKGDKRKDG IYELLIMNY
Length:289
Mass (Da):34,235
Last modified:November 1, 1996 - v1
Checksum:iCA95493C5CED8E78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98590.1.
PIRiF64374.
RefSeqiNP_247580.1. NC_000909.1.
WP_010870102.1. NC_000909.1.

Genome annotation databases

EnsemblBacteriaiAAB98590; AAB98590; MJ_0598.
GeneIDi1451463.
KEGGimja:MJ_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA. Translation: AAB98590.1 .
PIRi F64374.
RefSeqi NP_247580.1. NC_000909.1.
WP_010870102.1. NC_000909.1.

3D structure databases

ProteinModelPortali Q58015.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243232.MJ0598.

Protein family/group databases

REBASEi 3890. M.MjaIII.

Proteomic databases

PRIDEi Q58015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB98590 ; AAB98590 ; MJ_0598 .
GeneIDi 1451463.
KEGGi mja:MJ_0598.

Phylogenomic databases

eggNOGi COG0338.
InParanoidi Q58015.
KOi K06223.
OMAi KFTREIY.
PhylomeDBi Q58015.

Family and domain databases

Gene3Di 1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProi IPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02086. MethyltransfD12. 1 hit.
[Graphical view ]
PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSi PR00505. D12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00571. dam. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

Entry informationi

Entry nameiMTM3_METJA
AccessioniPrimary (citable) accession number: Q58015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
  2. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3