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Q58015

- MTM3_METJA

UniProt

Q58015 - MTM3_METJA

Protein

Modification methylase MjaIII

Gene

mjaIIIM

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease.Curated

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91S-adenosyl-L-methionineBy similarity
    Binding sitei13 – 131S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei63 – 631S-adenosyl-L-methionineBy similarity
    Binding sitei199 – 1991S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3890. M.MjaIII.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase MjaIII (EC:2.1.1.72)
    Short name:
    M.MjaIII
    Alternative name(s):
    Adenine-specific methyltransferase MjaIII
    Gene namesi
    Name:mjaIIIM
    Ordered Locus Names:MJ0598
    OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
    Taxonomic identifieri243232 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
    ProteomesiUP000000805: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Modification methylase MjaIIIPRO_0000087976Add
    BLAST

    Proteomic databases

    PRIDEiQ58015.

    Interactioni

    Protein-protein interaction databases

    STRINGi243232.MJ0598.

    Structurei

    3D structure databases

    ProteinModelPortaliQ58015.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0338.
    KOiK06223.
    OMAiKFTREIY.
    PhylomeDBiQ58015.

    Family and domain databases

    Gene3Di1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02086. MethyltransfD12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSiPR00505. D12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00571. dam. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q58015-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVKPFLKWA GGKTQILSQI EENLPKELKE GNIKKYIEPF VGGGAVLFYL    50
    LQKYEFKKVI ISDINEDLML CYKVVKNDVD RLIEELSSLR DEFLSLDEEK 100
    RKEFYYKVRD DFNKNKNDCD EVKRVAQFIF LNKTCYNGLY RVNKKGEFNV 150
    PYGRYKNPKI FDEQNLKNVS KLLKNVKILC GDFEIVDEYV DAESFVYFDP 200
    PYKPLNKTSS FTSYTKYDFN DDDQIRLAKF YRKLDKRGAK LMLSNSYNVD 250
    FFGKLYEGFN IKKVVAKRMI NCKGDKRKDG IYELLIMNY 289
    Length:289
    Mass (Da):34,235
    Last modified:November 1, 1996 - v1
    Checksum:iCA95493C5CED8E78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98590.1.
    PIRiF64374.
    RefSeqiNP_247580.1. NC_000909.1.
    WP_010870102.1. NC_000909.1.

    Genome annotation databases

    EnsemblBacteriaiAAB98590; AAB98590; MJ_0598.
    GeneIDi1451463.
    KEGGimja:MJ_0598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L77117 Genomic DNA. Translation: AAB98590.1 .
    PIRi F64374.
    RefSeqi NP_247580.1. NC_000909.1.
    WP_010870102.1. NC_000909.1.

    3D structure databases

    ProteinModelPortali Q58015.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243232.MJ0598.

    Protein family/group databases

    REBASEi 3890. M.MjaIII.

    Proteomic databases

    PRIDEi Q58015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB98590 ; AAB98590 ; MJ_0598 .
    GeneIDi 1451463.
    KEGGi mja:MJ_0598.

    Phylogenomic databases

    eggNOGi COG0338.
    KOi K06223.
    OMAi KFTREIY.
    PhylomeDBi Q58015.

    Family and domain databases

    Gene3Di 1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02086. MethyltransfD12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSi PR00505. D12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00571. dam. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440.

    Entry informationi

    Entry nameiMTM3_METJA
    AccessioniPrimary (citable) accession number: Q58015
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Methanococcus jannaschii
      Methanococcus jannaschii: entries and gene names
    2. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3