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Q58015 (MTM3_METJA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Modification methylase MjaIII
Short name=M.MjaIII
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase MjaIII
Gene names
Name:mjaIIIM
Ordered Locus Names:MJ0598
OrganismMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) [Reference proteome] [HAMAP]
Taxonomic identifier243232 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus ›

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease Potential.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Modification methylase MjaIII
PRO_0000087976

Sites

Binding site91S-adenosyl-L-methionine By similarity
Binding site131S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site631S-adenosyl-L-methionine By similarity
Binding site1991S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q58015 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CA95493C5CED8E78

FASTA28934,235
        10         20         30         40         50         60 
MEVKPFLKWA GGKTQILSQI EENLPKELKE GNIKKYIEPF VGGGAVLFYL LQKYEFKKVI 

        70         80         90        100        110        120 
ISDINEDLML CYKVVKNDVD RLIEELSSLR DEFLSLDEEK RKEFYYKVRD DFNKNKNDCD 

       130        140        150        160        170        180 
EVKRVAQFIF LNKTCYNGLY RVNKKGEFNV PYGRYKNPKI FDEQNLKNVS KLLKNVKILC 

       190        200        210        220        230        240 
GDFEIVDEYV DAESFVYFDP PYKPLNKTSS FTSYTKYDFN DDDQIRLAKF YRKLDKRGAK 

       250        260        270        280 
LMLSNSYNVD FFGKLYEGFN IKKVVAKRMI NCKGDKRKDG IYELLIMNY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L77117 Genomic DNA. Translation: AAB98590.1.
PIRF64374.
RefSeqNP_247580.1. NC_000909.1.

3D structure databases

ProteinModelPortalQ58015.
ModBaseSearch...

Protein-protein interaction databases

STRING243232.MJ0598.

Protein family/group databases

REBASE3890. M.MjaIII.

Proteomic databases

PRIDEQ58015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB98590; AAB98590; MJ_0598.
GeneID1451463.
KEGGmja:MJ_0598.

Phylogenomic databases

eggNOGCOG0338.
KOK06223.
OMAKARRTIS.
ProtClustDBCLSK2517633.

Family and domain databases

Gene3D1.10.1020.10. 1 hit.
InterProIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
[Graphical view]
PfamPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSPR00505. D12N6MTFRASE.
TIGRFAMsTIGR00571. dam. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTM3_METJA
AccessionPrimary (citable) accession number: Q58015
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries

Methanococcus jannaschii

Methanococcus jannaschii: entries and gene names

SIMILARITY comments

Index of protein domains and families

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