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Protein
Submitted name:

Trans-sialidase

Gene

Tb927.7.6850

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • ganglioside catabolic process Source: GO_Central
  • oligosaccharide catabolic process Source: GO_Central
  • pathogenesis Source: GeneDB
  • sialic acid transport Source: GeneDB

Keywordsi

Molecular functionGlycosidaseImported, Hydrolase

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Names & Taxonomyi

Protein namesi
Submitted name:
Trans-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
ORF Names:Tb927.7.6850Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000008524 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.7.6850

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: GeneDB
  • cytoplasm Source: GO_Central
  • intracellular membrane-bounded organelle Source: GO_Central
  • membrane Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_501013964928 – 771Sequence analysisAdd BLAST744

Proteomic databases

PaxDbiQ57XJ2

Interactioni

Protein-protein interaction databases

STRINGi5691.AAZ12746

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 473SialidaseInterPro annotationAdd BLAST340

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili484 – 504Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000137392
KOiK01186

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR011040 Sialidase
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
IPR008377 Sialidase_trypan
PANTHERiPTHR10628 PTHR10628, 1 hit
PfamiView protein in Pfam
PF13859 BNR_3, 1 hit
PRINTSiPR01803 TCSIALIDASE
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q57XJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELHQQMRM PISRLLLIFT AVCHCCALTS KAAGKGTTRE AFLSGGAWAL
60 70 80 90 100
RKKLSEKDGE VWWWQDGPNW KDKYDKEWER WFKEEKGPWG GSEKRSEWFA
110 120 130 140 150
RMTGGYITLG KTKILSSAIE GSDKVERTVH SFRIPSFVEV DGVLMGIGDA
160 170 180 190 200
RYLTSTDYFF TDTVAKYSAD GGKTWKTEVI IENGRVDPTY SRVVDPTVVA
210 220 230 240 250
KADSVFVLVA RYNVTKGYWH NENNAAGIAD WEPFMYKGVV TKGADGKTSD
260 270 280 290 300
VRISWTKTPL KPLYDFTVAG SKGTQFIGGA GNGVVTLNGT ILFPVQARNE
310 320 330 340 350
DNAVVSMVMY SVDDGVSWHF ARGETALLTS EASLTEWNGK LLMSARTDTS
360 370 380 390 400
GVNVEGGFRK VFESNNLGAT WEESLGTISR VIGNSPDRTK PSPTANYPGS
410 420 430 440 450
SGALITVTLG DVPVMLITHP KNTKGAWSRD RLQLWMTDGN RMWLVGQISE
460 470 480 490 500
GDDNSAYSSL LLARDGLLYC LHEQNIDEVY GLHLVHLVDE LEKVNATVRK
510 520 530 540 550
WKAQDALLAG LCSSSRKKND PTCSGVPTDG LVGLLAGPVG ASVWADVYDC
560 570 580 590 600
VNASISDGVK VSEGVQLGGK RNSRVLWPVS EQGQDQRYYF ANTHFTLLAT
610 620 630 640 650
VRFAGEPKAE APLMGFSNAE GKTSETLSLT VGGKKWVLTY GSVRKEGPTT
660 670 680 690 700
SMDWNQTHQI ALTLRDGKVD AHVNGELIIK EVSVGASESS AHLHLSHFFI
710 720 730 740 750
GAPVNDSGEG GNNVIVRNVL LYNRKLDEDE LQLLYSNREK IQPVVSAVGI
760 770
PEGMSAPRLC CLLILMYVLA I
Length:771
Mass (Da):84,544
Last modified:May 10, 2005 - v1
Checksum:i4E8C55C6FEEACDC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159415 Genomic DNA Translation: AAX69677.1
CP000070 Genomic DNA Translation: AAZ12746.1
RefSeqiXP_846305.1, XM_841212.1

Genome annotation databases

GeneDBiTb927.7.6850:pep
GeneIDi3658905
KEGGitbr:Tb927.7.6850

Similar proteinsi

Entry informationi

Entry nameiQ57XJ2_TRYB2
AccessioniPrimary (citable) accession number: Q57XJ2
Secondary accession number(s): D6XJL3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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