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Protein
Submitted name:

Trans-sialidase

Gene

Tb927.7.6850

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: GeneDB
  • sialic acid transport Source: GeneDB
  • sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Trans-sialidaseImported (EC:3.2.1.18Imported)
Gene namesi
ORF Names:Tb927.7.6850Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: GeneDB
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ57XJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000137392.
InParanoidiQ57XJ2.
KOiK01186.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57XJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELHQQMRM PISRLLLIFT AVCHCCALTS KAAGKGTTRE AFLSGGAWAL
60 70 80 90 100
RKKLSEKDGE VWWWQDGPNW KDKYDKEWER WFKEEKGPWG GSEKRSEWFA
110 120 130 140 150
RMTGGYITLG KTKILSSAIE GSDKVERTVH SFRIPSFVEV DGVLMGIGDA
160 170 180 190 200
RYLTSTDYFF TDTVAKYSAD GGKTWKTEVI IENGRVDPTY SRVVDPTVVA
210 220 230 240 250
KADSVFVLVA RYNVTKGYWH NENNAAGIAD WEPFMYKGVV TKGADGKTSD
260 270 280 290 300
VRISWTKTPL KPLYDFTVAG SKGTQFIGGA GNGVVTLNGT ILFPVQARNE
310 320 330 340 350
DNAVVSMVMY SVDDGVSWHF ARGETALLTS EASLTEWNGK LLMSARTDTS
360 370 380 390 400
GVNVEGGFRK VFESNNLGAT WEESLGTISR VIGNSPDRTK PSPTANYPGS
410 420 430 440 450
SGALITVTLG DVPVMLITHP KNTKGAWSRD RLQLWMTDGN RMWLVGQISE
460 470 480 490 500
GDDNSAYSSL LLARDGLLYC LHEQNIDEVY GLHLVHLVDE LEKVNATVRK
510 520 530 540 550
WKAQDALLAG LCSSSRKKND PTCSGVPTDG LVGLLAGPVG ASVWADVYDC
560 570 580 590 600
VNASISDGVK VSEGVQLGGK RNSRVLWPVS EQGQDQRYYF ANTHFTLLAT
610 620 630 640 650
VRFAGEPKAE APLMGFSNAE GKTSETLSLT VGGKKWVLTY GSVRKEGPTT
660 670 680 690 700
SMDWNQTHQI ALTLRDGKVD AHVNGELIIK EVSVGASESS AHLHLSHFFI
710 720 730 740 750
GAPVNDSGEG GNNVIVRNVL LYNRKLDEDE LQLLYSNREK IQPVVSAVGI
760 770
PEGMSAPRLC CLLILMYVLA I
Length:771
Mass (Da):84,544
Last modified:May 10, 2005 - v1
Checksum:i4E8C55C6FEEACDC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159415 Genomic DNA. Translation: AAX69677.1.
CP000070 Genomic DNA. Translation: AAZ12746.1.
RefSeqiXP_846305.1. XM_841212.1.

Genome annotation databases

GeneIDi3658905.
KEGGitbr:Tb927.7.6850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159415 Genomic DNA. Translation: AAX69677.1.
CP000070 Genomic DNA. Translation: AAZ12746.1.
RefSeqiXP_846305.1. XM_841212.1.

3D structure databases

ProteinModelPortaliQ57XJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3658905.
KEGGitbr:Tb927.7.6850.

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000137392.
InParanoidiQ57XJ2.
KOiK01186.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  2. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.

Entry informationi

Entry nameiQ57XJ2_TRYB2
AccessioniPrimary (citable) accession number: Q57XJ2
Secondary accession number(s): D6XJL3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.