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Q57XJ2

- Q57XJ2_TRYB2

UniProt

Q57XJ2 - Q57XJ2_TRYB2

Protein
Submitted name:

Trans-sialidase

Gene

Tb927.7.6850

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
    4. exo-alpha-sialidase activity Source: GeneDB_Tbrucei
    5. sialyltransferase activity Source: GeneDB_Tbrucei

    GO - Biological processi

    1. pathogenesis Source: GeneDB_Tbrucei
    2. sialic acid transport Source: GeneDB_Tbrucei
    3. sialylation Source: GOC

    Keywords - Molecular functioni

    GlycosidaseImported, Hydrolase

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Trans-sialidaseImported (EC:3.2.1.18Imported)
    Gene namesi
    ORF Names:Tb927.7.6850Imported
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
    Taxonomic identifieri999953 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    ProteomesiUP000008524: Chromosome 7

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: GeneDB_Tbrucei

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG4409.
    HOGENOMiHOG000137392.
    KOiK01186.
    OMAiHEQNIDE.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57XJ2-1 [UniParc]FASTAAdd to Basket

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    MEELHQQMRM PISRLLLIFT AVCHCCALTS KAAGKGTTRE AFLSGGAWAL    50
    RKKLSEKDGE VWWWQDGPNW KDKYDKEWER WFKEEKGPWG GSEKRSEWFA 100
    RMTGGYITLG KTKILSSAIE GSDKVERTVH SFRIPSFVEV DGVLMGIGDA 150
    RYLTSTDYFF TDTVAKYSAD GGKTWKTEVI IENGRVDPTY SRVVDPTVVA 200
    KADSVFVLVA RYNVTKGYWH NENNAAGIAD WEPFMYKGVV TKGADGKTSD 250
    VRISWTKTPL KPLYDFTVAG SKGTQFIGGA GNGVVTLNGT ILFPVQARNE 300
    DNAVVSMVMY SVDDGVSWHF ARGETALLTS EASLTEWNGK LLMSARTDTS 350
    GVNVEGGFRK VFESNNLGAT WEESLGTISR VIGNSPDRTK PSPTANYPGS 400
    SGALITVTLG DVPVMLITHP KNTKGAWSRD RLQLWMTDGN RMWLVGQISE 450
    GDDNSAYSSL LLARDGLLYC LHEQNIDEVY GLHLVHLVDE LEKVNATVRK 500
    WKAQDALLAG LCSSSRKKND PTCSGVPTDG LVGLLAGPVG ASVWADVYDC 550
    VNASISDGVK VSEGVQLGGK RNSRVLWPVS EQGQDQRYYF ANTHFTLLAT 600
    VRFAGEPKAE APLMGFSNAE GKTSETLSLT VGGKKWVLTY GSVRKEGPTT 650
    SMDWNQTHQI ALTLRDGKVD AHVNGELIIK EVSVGASESS AHLHLSHFFI 700
    GAPVNDSGEG GNNVIVRNVL LYNRKLDEDE LQLLYSNREK IQPVVSAVGI 750
    PEGMSAPRLC CLLILMYVLA I 771
    Length:771
    Mass (Da):84,544
    Last modified:May 10, 2005 - v1
    Checksum:i4E8C55C6FEEACDC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159415 Genomic DNA. Translation: AAX69677.1.
    CP000070 Genomic DNA. Translation: AAZ12746.1.
    RefSeqiXP_846305.1. XM_841212.1.

    Genome annotation databases

    EnsemblProtistsiAAZ12746; AAZ12746; Tb927.7.6850.
    GeneIDi3658905.
    KEGGitbr:Tb927.7.6850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159415 Genomic DNA. Translation: AAX69677.1 .
    CP000070 Genomic DNA. Translation: AAZ12746.1 .
    RefSeqi XP_846305.1. XM_841212.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi AAZ12746 ; AAZ12746 ; Tb927.7.6850 .
    GeneIDi 3658905.
    KEGGi tbr:Tb927.7.6850.

    Phylogenomic databases

    eggNOGi COG4409.
    HOGENOMi HOG000137392.
    KOi K01186.
    OMAi HEQNIDE.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    2. "The genome of the African trypanosome Trypanosoma brucei."
      Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
      , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
      Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 927/4 GUTat10.1Imported.
    3. "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
      Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.
      , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUTat10.1Imported.

    Entry informationi

    Entry nameiQ57XJ2_TRYB2
    AccessioniPrimary (citable) accession number: Q57XJ2
    Secondary accession number(s): D6XJL3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3