Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q57XD7

- Q57XD7_TRYB2

UniProt

Q57XD7 - Q57XD7_TRYB2

Protein

Acetyl-coenzyme A synthetase

Gene

Tb927.8.2520

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

    GO - Molecular functioni

    1. acetate-CoA ligase activity Source: UniProtKB-EC
    2. AMP binding Source: InterPro
    3. catalytic activity Source: GeneDB_Tbrucei

    GO - Biological processi

    1. acetyl-CoA biosynthetic process from acetate Source: InterPro
    2. metabolic process Source: GeneDB_Tbrucei

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
    Gene namesi
    ORF Names:Tb927.8.2520Imported
    OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
    Taxonomic identifieri999953 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
    ProteomesiUP000008524: Chromosome 8

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GeneDB_Tbrucei

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0365.
    HOGENOMiHOG000229981.
    KOiK01895.
    OMAiCTIDSAG.

    Family and domain databases

    InterProiIPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57XD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDTGRCSGH NDDVVDPVTS NGAMSHVGPD LAHRQALYEE SVRDPVAFWE    50
    QAAADFHWER TWPKDKSPLE YNFHKSNGSI FVKWFDGAES NMCYNALDRH 100
    LPKHKDRVCY HWEGNDEGES RDVTYGEMFE EVVRIAAVLK HRYNVKKGDV 150
    VTIYLPMIPF AAQVMLAVAR LGAVTSVVFA GFSSQAVASR LTDARSKLII 200
    TADSFWRGTK TLLLKELSDA ALAICEAEGH NVQCLVYDRS KRENVPMTEG 250
    RDAWYSDVVE TLTASELADC PIVWIGAEDP LFLLYTSGST GKPKAILHTL 300
    GGYMVYAGVT FKYSFDYHES DVSFCTADIG WITGHSYALY GPMLNAATSV 350
    LFEGMPTHPT PSRWWDLVDK YRVTIFYTAP TAIRALMQCG DEHLQSTTRG 400
    TLRILGSVGE PINAEAWQWF YEVVGKRRAD VIDTWWQTET GGHLITPLPG 450
    CTPMKAGSAT LPFFGIVPAL LHPTTNAVVE GEGEGLLAMQ TPWPGIARTI 500
    FGDHNRYEQA YFAVDGFYLT GDGARRDKDG YYWITGRVDD VLNVSGHRIG 550
    TSEVEEAVNS HPDVAESAAV GIPHDVKGEC IYVFVTFNNN VTVDATLLKR 600
    VRETVRRVIG PFAAPDYVQA AQCGLPKTRS GKIMRRILRK IASGLHEELG 650
    DTSTLLDPSV VQNLIEGRKQ TVG 673
    Length:673
    Mass (Da):74,666
    Last modified:May 10, 2005 - v1
    Checksum:i4E2CFD509EB14D8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159420 Genomic DNA. Translation: AAX69719.1.
    CP000071 Genomic DNA. Translation: AAZ13019.1.
    RefSeqiXP_847085.1. XM_841992.1.

    Genome annotation databases

    EnsemblProtistsiAAZ13019; AAZ13019; Tb927.8.2520.
    GeneIDi3659232.
    KEGGitbr:Tb927.8.2520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC159420 Genomic DNA. Translation: AAX69719.1 .
    CP000071 Genomic DNA. Translation: AAZ13019.1 .
    RefSeqi XP_847085.1. XM_841992.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi AAZ13019 ; AAZ13019 ; Tb927.8.2520 .
    GeneIDi 3659232.
    KEGGi tbr:Tb927.8.2520.

    Phylogenomic databases

    eggNOGi COG0365.
    HOGENOMi HOG000229981.
    KOi K01895.
    OMAi CTIDSAG.

    Family and domain databases

    InterProi IPR011904. Ac_CoA_lig.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    2. "The genome of the African trypanosome Trypanosoma brucei."
      Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
      , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
      Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 927/4 GUTat10.1Imported.
    3. "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
      Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.
      , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 927/4 GUTat10.1Imported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: GUTat10.1Imported.

    Entry informationi

    Entry nameiQ57XD7_TRYB2
    AccessioniPrimary (citable) accession number: Q57XD7
    Secondary accession number(s): D6XKY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3