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Protein

Acetyl-coenzyme A synthetase

Gene

Tb927.8.2520

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
ORF Names:Tb927.8.2520Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000008524 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiTriTrypDB:Tb927.8.2520

PTM / Processingi

Proteomic databases

PaxDbiQ57XD7

PTM databases

SwissPalmiQ57XD7

Interactioni

Protein-protein interaction databases

STRINGi5691.AAZ13019

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 96ACAS_NInterPro annotationAdd BLAST62
Domaini99 – 544AMP-bindingInterPro annotationAdd BLAST446
Domaini553 – 632AMP-binding_CInterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229981
KOiK01895
OMAiVNCLDQH

Family and domain databases

CDDicd05966 ACS, 1 hit
InterProiView protein in InterPro
IPR011904 Ac_CoA_lig
IPR032387 ACAS_N
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
TIGRFAMsiTIGR02188 Ac_CoA_lig_AcsA, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q57XD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDTGRCSGH NDDVVDPVTS NGAMSHVGPD LAHRQALYEE SVRDPVAFWE
60 70 80 90 100
QAAADFHWER TWPKDKSPLE YNFHKSNGSI FVKWFDGAES NMCYNALDRH
110 120 130 140 150
LPKHKDRVCY HWEGNDEGES RDVTYGEMFE EVVRIAAVLK HRYNVKKGDV
160 170 180 190 200
VTIYLPMIPF AAQVMLAVAR LGAVTSVVFA GFSSQAVASR LTDARSKLII
210 220 230 240 250
TADSFWRGTK TLLLKELSDA ALAICEAEGH NVQCLVYDRS KRENVPMTEG
260 270 280 290 300
RDAWYSDVVE TLTASELADC PIVWIGAEDP LFLLYTSGST GKPKAILHTL
310 320 330 340 350
GGYMVYAGVT FKYSFDYHES DVSFCTADIG WITGHSYALY GPMLNAATSV
360 370 380 390 400
LFEGMPTHPT PSRWWDLVDK YRVTIFYTAP TAIRALMQCG DEHLQSTTRG
410 420 430 440 450
TLRILGSVGE PINAEAWQWF YEVVGKRRAD VIDTWWQTET GGHLITPLPG
460 470 480 490 500
CTPMKAGSAT LPFFGIVPAL LHPTTNAVVE GEGEGLLAMQ TPWPGIARTI
510 520 530 540 550
FGDHNRYEQA YFAVDGFYLT GDGARRDKDG YYWITGRVDD VLNVSGHRIG
560 570 580 590 600
TSEVEEAVNS HPDVAESAAV GIPHDVKGEC IYVFVTFNNN VTVDATLLKR
610 620 630 640 650
VRETVRRVIG PFAAPDYVQA AQCGLPKTRS GKIMRRILRK IASGLHEELG
660 670
DTSTLLDPSV VQNLIEGRKQ TVG
Length:673
Mass (Da):74,666
Last modified:May 10, 2005 - v1
Checksum:i4E2CFD509EB14D8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159420 Genomic DNA Translation: AAX69719.1
CP000071 Genomic DNA Translation: AAZ13019.1
RefSeqiXP_847085.1, XM_841992.1

Genome annotation databases

GeneDBiTb927.8.2520:pep
GeneIDi3659232
KEGGitbr:Tb927.8.2520

Similar proteinsi

Entry informationi

Entry nameiQ57XD7_TRYB2
AccessioniPrimary (citable) accession number: Q57XD7
Secondary accession number(s): D6XKY9
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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