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Q57XD7

- Q57XD7_TRYB2

UniProt

Q57XD7 - Q57XD7_TRYB2

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Protein

Acetyl-coenzyme A synthetase

Gene

Tb927.8.2520

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-EC
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. catalytic activity Source: GeneDB_Tbrucei

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
  2. metabolic process Source: GeneDB_Tbrucei
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
ORF Names:Tb927.8.2520Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 8

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: GeneDB_Tbrucei
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliQ57XD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiCTIDSAG.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57XD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDTGRCSGH NDDVVDPVTS NGAMSHVGPD LAHRQALYEE SVRDPVAFWE
60 70 80 90 100
QAAADFHWER TWPKDKSPLE YNFHKSNGSI FVKWFDGAES NMCYNALDRH
110 120 130 140 150
LPKHKDRVCY HWEGNDEGES RDVTYGEMFE EVVRIAAVLK HRYNVKKGDV
160 170 180 190 200
VTIYLPMIPF AAQVMLAVAR LGAVTSVVFA GFSSQAVASR LTDARSKLII
210 220 230 240 250
TADSFWRGTK TLLLKELSDA ALAICEAEGH NVQCLVYDRS KRENVPMTEG
260 270 280 290 300
RDAWYSDVVE TLTASELADC PIVWIGAEDP LFLLYTSGST GKPKAILHTL
310 320 330 340 350
GGYMVYAGVT FKYSFDYHES DVSFCTADIG WITGHSYALY GPMLNAATSV
360 370 380 390 400
LFEGMPTHPT PSRWWDLVDK YRVTIFYTAP TAIRALMQCG DEHLQSTTRG
410 420 430 440 450
TLRILGSVGE PINAEAWQWF YEVVGKRRAD VIDTWWQTET GGHLITPLPG
460 470 480 490 500
CTPMKAGSAT LPFFGIVPAL LHPTTNAVVE GEGEGLLAMQ TPWPGIARTI
510 520 530 540 550
FGDHNRYEQA YFAVDGFYLT GDGARRDKDG YYWITGRVDD VLNVSGHRIG
560 570 580 590 600
TSEVEEAVNS HPDVAESAAV GIPHDVKGEC IYVFVTFNNN VTVDATLLKR
610 620 630 640 650
VRETVRRVIG PFAAPDYVQA AQCGLPKTRS GKIMRRILRK IASGLHEELG
660 670
DTSTLLDPSV VQNLIEGRKQ TVG
Length:673
Mass (Da):74,666
Last modified:May 10, 2005 - v1
Checksum:i4E2CFD509EB14D8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159420 Genomic DNA. Translation: AAX69719.1.
CP000071 Genomic DNA. Translation: AAZ13019.1.
RefSeqiXP_847085.1. XM_841992.1.

Genome annotation databases

GeneIDi3659232.
KEGGitbr:Tb927.8.2520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159420 Genomic DNA. Translation: AAX69719.1 .
CP000071 Genomic DNA. Translation: AAZ13019.1 .
RefSeqi XP_847085.1. XM_841992.1.

3D structure databases

ProteinModelPortali Q57XD7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3659232.
KEGGi tbr:Tb927.8.2520.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi CTIDSAG.

Family and domain databases

InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  2. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.

Entry informationi

Entry nameiQ57XD7_TRYB2
AccessioniPrimary (citable) accession number: Q57XD7
Secondary accession number(s): D6XKY9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3