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Q57XD7

- Q57XD7_TRYB2

UniProt

Q57XD7 - Q57XD7_TRYB2

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Protein

Acetyl-coenzyme A synthetase

Gene
Tb927.8.2520
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-EC
  2. AMP binding Source: InterPro

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Gene namesi
ORF Names:Tb927.8.2520Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)
Taxonomic identifieri999953 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524: Chromosome 8

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiCTIDSAG.

Family and domain databases

InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57XD7-1 [UniParc]FASTAAdd to Basket

« Hide

MRDTGRCSGH NDDVVDPVTS NGAMSHVGPD LAHRQALYEE SVRDPVAFWE    50
QAAADFHWER TWPKDKSPLE YNFHKSNGSI FVKWFDGAES NMCYNALDRH 100
LPKHKDRVCY HWEGNDEGES RDVTYGEMFE EVVRIAAVLK HRYNVKKGDV 150
VTIYLPMIPF AAQVMLAVAR LGAVTSVVFA GFSSQAVASR LTDARSKLII 200
TADSFWRGTK TLLLKELSDA ALAICEAEGH NVQCLVYDRS KRENVPMTEG 250
RDAWYSDVVE TLTASELADC PIVWIGAEDP LFLLYTSGST GKPKAILHTL 300
GGYMVYAGVT FKYSFDYHES DVSFCTADIG WITGHSYALY GPMLNAATSV 350
LFEGMPTHPT PSRWWDLVDK YRVTIFYTAP TAIRALMQCG DEHLQSTTRG 400
TLRILGSVGE PINAEAWQWF YEVVGKRRAD VIDTWWQTET GGHLITPLPG 450
CTPMKAGSAT LPFFGIVPAL LHPTTNAVVE GEGEGLLAMQ TPWPGIARTI 500
FGDHNRYEQA YFAVDGFYLT GDGARRDKDG YYWITGRVDD VLNVSGHRIG 550
TSEVEEAVNS HPDVAESAAV GIPHDVKGEC IYVFVTFNNN VTVDATLLKR 600
VRETVRRVIG PFAAPDYVQA AQCGLPKTRS GKIMRRILRK IASGLHEELG 650
DTSTLLDPSV VQNLIEGRKQ TVG 673
Length:673
Mass (Da):74,666
Last modified:May 10, 2005 - v1
Checksum:i4E2CFD509EB14D8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC159420 Genomic DNA. Translation: AAX69719.1.
CP000071 Genomic DNA. Translation: AAZ13019.1.
RefSeqiXP_847085.1. XM_841992.1.

Genome annotation databases

EnsemblProtistsiAAZ13019; AAZ13019; Tb927.8.2520.
GeneIDi3659232.
KEGGitbr:Tb927.8.2520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC159420 Genomic DNA. Translation: AAX69719.1 .
CP000071 Genomic DNA. Translation: AAZ13019.1 .
RefSeqi XP_847085.1. XM_841992.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi AAZ13019 ; AAZ13019 ; Tb927.8.2520 .
GeneIDi 3659232.
KEGGi tbr:Tb927.8.2520.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi CTIDSAG.

Family and domain databases

InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  2. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  3. "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2 through 8."
    Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L., Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J., Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.
    , Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O., Wortman J., Fraser C.M., El-Sayed N.M.A.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.

Entry informationi

Entry nameiQ57XD7_TRYB2
AccessioniPrimary (citable) accession number: Q57XD7
Secondary accession number(s): D6XKY9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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