ID   Q57VM1_TRYB2            Unreviewed;       276 AA.
AC   Q57VM1; D6XMW1;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   RecName: Full=60S ribosomal protein L7a {ECO:0000256|RuleBase:RU367042};
GN   Name=Tb08.29O4.580 {ECO:0000313|EMBL:AAZ12903.1};
GN   Synonyms=Tb08.29O4.590 {ECO:0000313|EMBL:AAZ12904.1};
GN   ORFNames=Tb927.8.1330 {ECO:0000313|EMBL:AAX70336.1}, Tb927.8.1340
GN   {ECO:0000313|EMBL:AAX70337.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:AAX70337.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:AAZ12903.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12903.1};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:AAZ12903.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12903.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [3] {ECO:0000313|EMBL:AAX70337.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GUTat10.1 {ECO:0000313|EMBL:AAX70337.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA   Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA   Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA   Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT   ".";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAZ12903.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:AAZ12903.1};
RA   Ghedin E., Blandin G., Bartholomeu D., Caler E., Haas B., Hannick L.,
RA   Shallom J., Hou L., Djikeng A., Feldblyum T., Hostetler J., Johnson J.,
RA   Jones K., Koo H.L., Larkin C., Pai G., Peterson J., Khalak H.G.,
RA   Salzberg S., Simpson A.J., Tallon L., Van Aken S., Wanless D., White O.,
RA   Wortman J., Fraser C.M., El-Sayed N.M.A.;
RT   "Sequencing, closure, and annotation of Trypanosoma brucei chromosomes 2
RT   through 8.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0007829|PDB:4V8M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX   PubMed=23395961; DOI=10.1038/nature11872;
RA   Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA   Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA   Madison-Antenucci S., Frank J.;
RT   "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT   brucei ribosome.";
RL   Nature 494:385-389(2013).
CC   -!- FUNCTION: Component of the ribosome. {ECO:0000256|RuleBase:RU367042}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000256|ARBA:ARBA00007337, ECO:0000256|RuleBase:RU367042}.
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DR   EMBL; AC159438; AAX70336.1; -; Genomic_DNA.
DR   EMBL; AC159438; AAX70337.1; -; Genomic_DNA.
DR   EMBL; CP000071; AAZ12903.1; -; Genomic_DNA.
DR   EMBL; CP000071; AAZ12904.1; -; Genomic_DNA.
DR   RefSeq; XP_846969.1; XM_841876.1.
DR   RefSeq; XP_846970.1; XM_841877.1.
DR   PDB; 4V8M; EM; 5.57 A; Bx=1-276.
DR   PDBsum; 4V8M; -.
DR   AlphaFoldDB; Q57VM1; -.
DR   EMDB; EMD-17208; -.
DR   EMDB; EMD-17212; -.
DR   IntAct; Q57VM1; 1.
DR   STRING; 185431.Q57VM1; -.
DR   PaxDb; 5691-AAZ12903; -.
DR   GeneID; 3659108; -.
DR   GeneID; 3659111; -.
DR   KEGG; tbr:Tb927.8.1330; -.
DR   KEGG; tbr:Tb927.8.1340; -.
DR   VEuPathDB; TriTrypDB:Tb927.8.1330; -.
DR   VEuPathDB; TriTrypDB:Tb927.8.1340; -.
DR   eggNOG; KOG3166; Eukaryota.
DR   InParanoid; Q57VM1; -.
DR   OMA; RYVKWPK; -.
DR   OrthoDB; 160374at2759; -.
DR   Proteomes; UP000008524; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IDA:GeneDB.
DR   GO; GO:0005840; C:ribosome; ISM:GeneDB.
DR   GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; ISM:GeneDB.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR001921; Ribosomal_eL8.
DR   InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR   InterPro; IPR018492; Ribosomal_eL8/Nhp2.
DR   PANTHER; PTHR23105:SF1; 60S RIBOSOMAL PROTEIN L7A; 1.
DR   PANTHER; PTHR23105; RIBOSOMAL PROTEIN L7AE FAMILY MEMBER; 1.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00882; RIBOSOMALL7A.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4V8M};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|RuleBase:RU367042};
KW   Ribosomal protein {ECO:0000256|RuleBase:RU367042,
KW   ECO:0000313|EMBL:AAX70337.1}.
FT   DOMAIN          145..218
FT                   /note="Ribosomal protein eL8/eL30/eS12/Gadd45"
FT                   /evidence="ECO:0000259|Pfam:PF01248"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  30879 MW;  31FA8793A72FAB61 CRC64;
     MAGKEVKKAV KPTKKAGVPY KKPEVTQKKA KASAAAPSPF VARPKDFGIG RDVPYARDLS
     RFMRWPTFVT MQRKKRVLQR RLKVPPALNQ FTKVLDRSSR NELLKLVKKY APETRKARRD
     RLTKVAEEKK KNPKGTVSTK APLCVVSGLQ EVTRTIEKKT ARLVLIANNV DPIELVLWMP
     TLCRANKIPY AIVKDKARLG DAIGRKTATC VAFTDVNAED QAALKNLTRS VNARFLARSD
     VIRRQWGGLQ LSLRSRAELR KKRARTAGND AAAKAA
//