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Protein
Submitted name:

Trans-sialidase, putative

Gene

Tb927.7.7480

Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Trans-sialidase, putativeImported (EC:3.2.1.18Imported)
Gene namesi
ORF Names:Tb927.7.7480Imported
OrganismiTrypanosoma brucei brucei (strain 927/4 GUTat10.1)Imported
Taxonomic identifieri185431 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
ProteomesiUP000008524 Componenti: Chromosome 7

Structurei

3D structure databases

ProteinModelPortaliQ57TY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000137392.
InParanoidiQ57TY5.
KOiK01186.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57TY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLQVRMGT LSLTSPFSML AYPFLPCTVV ILSVLSFCCG IVSSKIYEKT
60 70 80 90 100
TREVFLEGGR WVRKSEWEKG SWKTSPEWNA GYEWWAWCMD SVAKEAKGEV
110 120 130 140 150
CRKEWLSQRK KGYTLVPRTK VPFREKNGTQ WMRNVHSFRV PSFVEVSGVL
160 170 180 190 200
VGIADVRYIS SADFTFTETV AKYSADGGDT WKTKVIIENS RVNTNFSRVV
210 220 230 240 250
DPTVAVKGNN IFVLVGRYNT SSKYWTWQHY GEDWDILMYK GTVIKEEKDG
260 270 280 290 300
NVTASITFEA PQNLKFLLAT VPSPGGHPPS QFLGGVGNAA VTPDGAIVFS
310 320 330 340 350
VQVKNTWNHV VGKLLYSTDD GKTWHFGAGE TPVGSTESSV VWWKDRLLVN
360 370 380 390 400
ARTAEYVGYR RVFETSDLGN TLKESISTLS RVIGNSPLRN QPGSSGSAIS
410 420 430 440 450
ITVEGMDVML ISQPKNEKGS FSRDHLQLWL TDGTRVFLVG QISQGDDNSP
460 470 480 490 500
YSSLLYTSDG KLYCLYEQKI EEVFTIYLAR LVDEMKMIKR VVLLWKAQDA
510 520 530 540 550
LLVGDCLSSV GGTRPCKGIP VGDLAGLLTG PAVGHVWPDV YKCVNASVSG
560 570 580 590 600
AVDNKRGVVL GGTSGSSVVW PVSEQGQDQR YYFANTHFTI VATVQFGAVP
610 620 630 640 650
QRDTPLIGFV NGEKNANKLF ILSIENTRWT LMYGEKCSEG SPVPSNLEET
660 670 680 690 700
HQIALALQDG LVVAYVDGKL AVAAINVSES DRVDLLNIRH FFVGTPASSD
710 720 730 740 750
LSDHTSITVH SVLLYNRRLS EGELQLVFTN REVIRAANPT TPLPVSSRVA
760 770 780 790 800
AGAGRQSHDG VFFTFGDHVS SVRSRYSDGG ILEYVYLLSV ISLCALTLFI
810
LTLVFQRRRD VVPTNI
Length:816
Mass (Da):90,234
Last modified:May 9, 2005 - v1
Checksum:i5A232168125F4CBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159702 Genomic DNA. Translation: AAX79971.1.
CP000070 Genomic DNA. Translation: AAZ12809.1.
RefSeqiXP_846368.1. XM_841275.1.

Genome annotation databases

GeneIDi3658977.
KEGGitbr:Tb927.7.7480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159702 Genomic DNA. Translation: AAX79971.1.
CP000070 Genomic DNA. Translation: AAZ12809.1.
RefSeqiXP_846368.1. XM_841275.1.

3D structure databases

ProteinModelPortaliQ57TY5.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3658977.
KEGGitbr:Tb927.7.7480.

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000137392.
InParanoidiQ57TY5.
KOiK01186.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 927/4 GUTat10.1Imported.
  2. "The genome of the African trypanosome Trypanosoma brucei."
    Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H., Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U., Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B., Alsmark U.C.M.
    , Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F., Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C., Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A., Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D., Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D., Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S., Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S., Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G., Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A., Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M., Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S., Walker D., Wanless D., Wang S., White B., White O., Whitehead S., Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E., Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E., Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.
    Science 309:416-422(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 927/4 GUTat10.1Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: GUTat10.1Imported.

Entry informationi

Entry nameiQ57TY5_TRYB2
AccessioniPrimary (citable) accession number: Q57TY5
Secondary accession number(s): D6XJS6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 9, 2005
Last sequence update: May 9, 2005
Last modified: March 31, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.