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Protein

Probable crotonobetaine/carnitine-CoA ligase

Gene

caiC

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Enzyme and pathway databases

BioCyciSENT321314:GJCS-70-MONOMER.
UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable crotonobetaine/carnitine-CoA ligaseUniRule annotation (EC:6.2.1.-UniRule annotation)
Gene namesi
Name:caiCUniRule annotation
Ordered Locus Names:SCH_0065
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000000538 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Probable crotonobetaine/carnitine-CoA ligasePRO_0000193069Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ57TJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

KOiK02182.
OMAiPYVHEFE.
OrthoDBiEOG6MH5BV.

Family and domain databases

HAMAPiMF_01524. CaiC.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57TJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIVGGQNLR QMWDDLAGVY GDKTALIFES CEGIVRQFSY ASLNEEINRT
60 70 80 90 100
ANLFYSLGIR KGDRVALHLD NCPEFIFCWF GLAKIGAIMV PINARLLGEE
110 120 130 140 150
SAWILQNSQV SLLVTSVQFY PMYREIRQDN STPLNHICLI GEQLPADDGV
160 170 180 190 200
SHFSQLQARQ SATLCYTPAL STDDTAEILF TSGTTSRPKG VVITHYNLRF
210 220 230 240 250
AGYYSAWQIA LRDDDVYMTV MPAFHIDCQC TAAMPAFSAG STFVLLEKYS
260 270 280 290 300
ARAFWDQVRR YQATVTECIP MMIRTLMVQP AAPTDRQHHL REVMFYLNLS
310 320 330 340 350
AQEKDAFTER FGVRLLTSYG MTETIVGIIG DRPGDKRRWP SIGRVGFSYE
360 370 380 390 400
AEIRDDQNRP LPAGEIGEIC IKGIPGKTIF KEYYMQPEAT AGALEPEGWL
410 420 430 440 450
HTGDSGYQDE DGYFYFVDRR CNMIKRGGEN VSCVELENII SAHPKIQDIV
460 470 480 490 500
VVGIKDAIRD EAIKAFIVLN EGETLSEAEF FSFCENNMAK FKVPSFMEIR
510
TDLPRNCSGK IIKKNLK
Length:517
Mass (Da):58,329
Last modified:May 10, 2005 - v1
Checksum:i6479B1264414E2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX63971.1.
RefSeqiWP_011264179.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX63971; AAX63971; SCH_0065.
KEGGisec:SCH_0065.
PATRICi32320555. VBISalEnt136302_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX63971.1.
RefSeqiWP_011264179.1. NC_006905.1.

3D structure databases

ProteinModelPortaliQ57TJ0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX63971; AAX63971; SCH_0065.
KEGGisec:SCH_0065.
PATRICi32320555. VBISalEnt136302_0305.

Phylogenomic databases

KOiK02182.
OMAiPYVHEFE.
OrthoDBiEOG6MH5BV.

Enzyme and pathway databases

UniPathwayiUPA00117.
BioCyciSENT321314:GJCS-70-MONOMER.

Family and domain databases

HAMAPiMF_01524. CaiC.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023456. CaiC.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiCAIC_SALCH
AccessioniPrimary (citable) accession number: Q57TJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: May 10, 2005
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.