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Reviewed, UniProtKB/Swiss-Prot Q57S43 (ALLB_SALCH)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Allantoinase
    EC=3.5.2.5
Alternative name(s):
    Allantoin-utilizing enzyme
Gene names
Name: allB
Ordered Locus Names: SCH_0562
OrganismSalmonella choleraesuis [Complete proteome] [HAMAP]
Taxonomic identifier28901 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

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Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring By similarity. HAMAP MF_01645

Catalytic activity

(S)-allantoin + H2O = allantoate. HAMAP MF_01645

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01645

Pathway

Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. HAMAP MF_01645

Subunit structure

Homotetramer By similarity. HAMAP MF_01645

Post-translational modification

Carbamylation allows a single lysine to coordinate two zinc ions By similarity. HAMAP MF_01645

Sequence similarities

Belongs to the DHOase family. Allantoinase subfamily.

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Ontologies

Keywords
   Biological processPurine metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processallantoin catabolic process

Inferred from electronic annotation. Source: HAMAP

purine base metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionallantoinase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Allantoinase HAMAP MF_01645
PRO_0000317682

Sites

Metal binding591Zinc 1 By similarity
Metal binding611Zinc 1 By similarity
Metal binding1461Zinc 1; via carbamate group By similarity
Metal binding1461Zinc 2; via carbamate group By similarity
Metal binding1861Zinc 2 By similarity
Metal binding2421Zinc 2 By similarity
Metal binding3151Zinc 1 By similarity

Amino acid modifications

Modified residue1461N6-carboxylysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q57S43-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: C3D19E82F3D51EC2

FASTA45349,959
        10         20         30         40         50         60 
MSFDLIIKNG TVILENEARV IDIAVQGGKI AAIGENLEEA KNVLDATGLI VSPGMVDAHT 

        70         80         90        100        110        120 
HISEPGRTHW EGYETGTRAA AKGGITTMIE MPLNQLPATV DRETIELKFD AAKGKLTIDA 

       130        140        150        160        170        180 
AQLGGLVSYN LDRLHELDEV GVVGFKCFVA TCGDRGIDND FRDVNDWQFY KGAQKLGEMD 

       190        200        210        220        230        240 
QTVLVHCENA LICDELGEEA KREGRVTAHD YVASRPVFTE VEAIRRVLYL AKAAGCRLHV 

       250        260        270        280        290        300 
CHISSPEGVE EVTRARQEGQ DVTCESCPHY FVLDTDQFEE IGTLAKCSPP IRDQENQKGM 

       310        320        330        340        350        360 
WEKLFNGEID CLVSDHSPCP PEMKAGNIMQ AWGGIAGLQN CMDVMFDEAV QKRGMSLPMF 

       370        380        390        400        410        420 
GKLMATNAAD IFGLKHKGRI APGKDADLVF IQPDSSYVLK NEDLEYRHKV SPYVGRTIGA 

       430        440        450 
RITKTILRGD VIYDIEHGFP VPPKGQFILK HQQ

« Hide

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References

[1]"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
Nucleic Acids Res. 33:1690-1698(2005) [PubMed: 15781495] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC-B67.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017220 Genomic DNA. Translation: AAX64468.1.
RefSeqYP_215549.1.

3D structure databases

HSSPHSSP built from PDB template 1GKR based on UniProtKB P81006.
SMRQ57S43. Positions 3-449.
ModBaseSearch...

Genome annotation databases

GeneID3332987.
GenomeReviewsGene locus SCH_0562 in contig AE017220_GR.
KEGGsec:SC0562.
NMPDRfig|321314.4.peg.529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG724623.
OMAHICHISS.

Enzyme and pathway databases

BioCycSENT321314:SCH_0562-MONOMER.
BRENDA3.5.2.5. 276841.

Family and domain databases

HAMAPMF_01645. Hydantoinase.
[Tree]
InterProIPR017593. Allantoinase.
IPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR03178. allantoinase. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameALLB_SALCH
AccessionPrimary (citable) accession number: Q57S43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 10, 2005
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents