UniProtKB - Q57RF9 (UVRB_SALCH)
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Protein
UvrABC system protein B
Gene
uvrB
Organism
Salmonella choleraesuis (strain SC-B67)
Status
Functioni
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 39 – 46 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: InterPro
- excinuclease ABC activity Source: InterPro
GO - Biological processi
- nucleotide-excision repair Source: InterPro
- SOS response Source: UniProtKB-KW
Keywordsi
Molecular function | Excision nuclease |
Biological process | DNA damage, DNA excision, DNA repair, SOS response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: UvrABC system protein BUniRule annotationShort name: Protein UvrBUniRule annotation Alternative name(s): Excinuclease ABC subunit BUniRule annotation |
Gene namesi | Name:uvrBUniRule annotation Ordered Locus Names:SCH_0796 |
Organismi | Salmonella choleraesuis (strain SC-B67) |
Taxonomic identifieri | 321314 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227357 | 1 – 673 | UvrABC system protein BAdd BLAST | 673 |
Interactioni
Subunit structurei
Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | Q57RF9. |
SMRi | Q57RF9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 414 | Helicase ATP-bindingUniRule annotationAdd BLAST | 389 | |
Domaini | 431 – 597 | Helicase C-terminalUniRule annotationAdd BLAST | 167 | |
Domaini | 633 – 668 | UVRUniRule annotationAdd BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 92 – 115 | Beta-hairpinAdd BLAST | 24 |
Domaini
The beta-hairpin motif is involved in DNA binding.UniRule annotation
Sequence similaritiesi
Belongs to the UvrB family.UniRule annotation
Phylogenomic databases
KOi | K03702. |
OMAi | RYMHSEI. |
Family and domain databases
CDDi | cd00079. HELICc. 1 hit. |
HAMAPi | MF_00204. UvrB. 1 hit. |
InterProi | View protein in InterPro IPR006935. Helicase/UvrB_N. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR027417. P-loop_NTPase. IPR001943. UVR_dom. IPR036876. UVR_dom_sf. IPR004807. UvrB. IPR024759. UvrB_YAD/RRR_dom. |
PANTHERi | PTHR24029. PTHR24029. 1 hit. |
Pfami | View protein in Pfam PF00271. Helicase_C. 1 hit. PF04851. ResIII. 1 hit. PF02151. UVR. 1 hit. PF12344. UvrB. 1 hit. |
SMARTi | View protein in SMART SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. |
SUPFAMi | SSF46600. SSF46600. 1 hit. SSF52540. SSF52540. 3 hits. |
TIGRFAMsi | TIGR00631. uvrb. 1 hit. |
PROSITEi | View protein in PROSITE PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50151. UVR. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q57RF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKPFKLNSA FKPSGDQPDA IRRLEEGLED GLAHQTLLGV TGSGKTFTIA
60 70 80 90 100
NVIADLQRPT MVLAPNKTLA AQLYGEMKEF FPENAVEYFV SYYDYYQPEA
110 120 130 140 150
YVPSSDTFIE KDASVNEHIE QMRLSATKAL LERRDVVVVA SVSAIYGLGD
160 170 180 190 200
PDLYLKMMLH LTVGMLIDQR AILRRLAELQ YTRNDQAFQR GTFRVRGEVI
210 220 230 240 250
DIFPAESDDI ALRVELFDEE VERLSLFDPL TGQVESTVPR YTIYPKTHYV
260 270 280 290 300
TPRERILQAM EEIKDELADR RKVLLANNKL LEEQRLSQRT QFDLEMMNEL
310 320 330 340 350
GYCSGIENYS RFLSGRGPGE PPPTLFDYLP ADGLLVVDES HVTIPQIGGM
360 370 380 390 400
YRGDRARKET LVEYGFRLPS ALDNRPLKFE EFEALAPQTI YVSATPGNYE
410 420 430 440 450
LEKSGDEVVD QVVRPTGLLD PIIEVRPVAT QVDDLLSEIR QRAAINERVL
460 470 480 490 500
VTTLTKRMAE DLTEYLEEHG ERVRYLHSDI DTVERMEIIR DLRLGEFDVL
510 520 530 540 550
VGINLLREGL DMPEVSLVAI LDADKEGFLR SERSLIQTIG RAARNVNGKA
560 570 580 590 600
ILYGDKITPS MAKAIGETER RREKQQKYNE EHGITPQGLN KKVVDILALG
610 620 630 640 650
QNIAKTKAKG KGKGRSTAKA GIVELDMTPK ALQQKIHELE GQMMQHAQNL
660 670
EFEEAAQIRD QLHQLRELFI AAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE017220 Genomic DNA. Translation: AAX64702.1. |
RefSeqi | WP_000042502.1. NC_006905.1. |
Genome annotation databases
EnsemblBacteriai | AAX64702; AAX64702; SCH_0796. |
KEGGi | sec:SCH_0796. |
Similar proteinsi
Entry informationi
Entry namei | UVRB_SALCH | |
Accessioni | Q57RF9Primary (citable) accession number: Q57RF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 28, 2018 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |