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Q57QE6

- NAGZ_SALCH

UniProt

Q57QE6 - NAGZ_SALCH

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Protein

Beta-hexosaminidase

Gene
nagZ, SCH_1159
Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei133 – 1331Substrate By similarity
Sitei174 – 1741Important for catalytic activity By similarity
Active sitei176 – 1761Proton donor/acceptor By similarity
Active sitei248 – 2481Nucleophile By similarity

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-KW
  5. peptidoglycan turnover Source: UniProtKB-HAMAP
  6. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSENT321314:GJCS-1222-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nagZ
Ordered Locus Names:SCH_1159
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Beta-hexosaminidaseUniRule annotationPRO_0000234921Add
BLAST

Proteomic databases

PRIDEiQ57QE6.

Interactioni

Protein-protein interaction databases

STRINGi321314.SC1159.

Structurei

3D structure databases

ProteinModelPortaliQ57QE6.
SMRiQ57QE6. Positions 1-334.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni163 – 1642Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1472.
OMAiYTEADPR.
OrthoDBiEOG6BCT06.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ.
InterProiIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57QE6-1 [UniParc]FASTAAdd to Basket

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MGPVMLNVEG CELDAEEREI LAHPLVGGLI LFTRNYHDPE QLRELVRQIR    50
AASRNHLVVA VDQEGGRVQR FREGFTRLPA AQSFFALHGL EEGGRLAQEA 100
GWLMASEMIA MDIDISFAPV LDVGHISAAI GERSYHADPA KALAMATRFI 150
DGMHDAGMKT TGKHFPGHGA VTADSHKETP CDPRPETDIR GKDMSVFRTL 200
ISENKLDAIM PAHVIYRAID PRPASGSPYW LKTVLRQELG FDGVIFSDDL 250
SMEGAAIMGS YAERAQASLD AGCDMILVCN NRKGAVSVLD NLSPIKAERV 300
TRLYHKGSFS RRELMDSARW KTASAQLNQL HERWQEEKAG H 341
Length:341
Mass (Da):37,698
Last modified:May 10, 2005 - v1
Checksum:iE07E83487336A300
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX65065.1.
RefSeqiYP_216146.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX65065; AAX65065; SCH_1159.
PATRICi32323060. VBISalEnt136302_1526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX65065.1 .
RefSeqi YP_216146.1. NC_006905.1.

3D structure databases

ProteinModelPortali Q57QE6.
SMRi Q57QE6. Positions 1-334.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321314.SC1159.

Proteomic databases

PRIDEi Q57QE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX65065 ; AAX65065 ; SCH_1159 .
PATRICi 32323060. VBISalEnt136302_1526.

Phylogenomic databases

eggNOGi COG1472.
OMAi YTEADPR.
OrthoDBi EOG6BCT06.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci SENT321314:GJCS-1222-MONOMER.

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
HAMAPi MF_00364. NagZ.
InterProi IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00933. Glyco_hydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiNAGZ_SALCH
AccessioniPrimary (citable) accession number: Q57QE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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