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Q57N70

- OTSA_SALCH

UniProt

Q57N70 - OTSA_SALCH

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Protein
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Gene
otsA, SCH_1935
Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of glucose from UDP-glucose to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor By similarity.

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101Glucose-6-phosphate By similarity
Binding sitei76 – 761Glucose-6-phosphate By similarity
Sitei85 – 851Involved in alpha anomer selectivity By similarity
Binding sitei130 – 1301Glucose-6-phosphate By similarity
Sitei155 – 1551Involved in alpha anomer selectivity By similarity
Binding sitei262 – 2621UDP-glucose By similarity
Binding sitei267 – 2671UDP-glucose By similarity
Binding sitei300 – 3001Glucose-6-phosphate By similarity
Binding sitei339 – 3391UDP-glucose; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. trehalose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSENT321314:GJCS-2024-MONOMER.
UniPathwayiUPA00299.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Osmoregulatory trehalose synthesis protein A
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:otsA
Ordered Locus Names:SCH_1935
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000348916Add
BLAST

Proteomic databases

PaxDbiQ57N70.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi321314.SC1935.

Structurei

3D structure databases

ProteinModelPortaliQ57N70.
SMRiQ57N70. Positions 2-456.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 222UDP-glucose binding By similarity
Regioni365 – 3695UDP-glucose binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0380.
OMAiWGESFVK.
OrthoDBiEOG6CCH1M.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57N70-1 [UniParc]FASTAAdd to Basket

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MSRLVVVSNR IAPPDNKGGA GGLAVGVLGA LKAAGGLWFG WSGETGNEDE    50
PLKKVTKGNI TWASFNLSEQ DYEDYYCQFS NAVLWPAFHY RLDLVQFQRP 100
AWEGYMRVNA LLADKLLPLI KENDIIWVHD YHLLPFASEL RKRGVNNRIG 150
FFLHIPFPTP EIFNALPPHD ELLEQLCDFD LLGFQTENDR LAFLDSLLSQ 200
TRVTTRSGKQ HIAWGKDFQT EVYPIGIEPD EIALQAAGPL PPKLAQLKAE 250
LKNVKNIFSV ERLDYSKGLP ERFLAYEALL ENYPQHRGKI RYTQIAPTSR 300
GEVQAYQDIR HQLETEAGRI NGKYGQLGWT PLYYLNQHFD RKLLMKIFRY 350
SDVGLVTPLR DGMNLVAKEF VAAQDPANPG VLVLSQFAGA ANELTSALIV 400
NPYDRDDVAA ALNRALTMPL AERISRHAEM LDVIVKNDIN RWQERFIHDL 450
KEVTPRSPER QQQNNVATFP KLA 473
Length:473
Mass (Da):53,607
Last modified:May 10, 2005 - v1
Checksum:i218FAF0F31658442
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX65841.1.
RefSeqiYP_216922.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX65841; AAX65841; SCH_1935.
PATRICi32324763. VBISalEnt136302_2369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX65841.1 .
RefSeqi YP_216922.1. NC_006905.1.

3D structure databases

ProteinModelPortali Q57N70.
SMRi Q57N70. Positions 2-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321314.SC1935.

Proteomic databases

PaxDbi Q57N70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX65841 ; AAX65841 ; SCH_1935 .
PATRICi 32324763. VBISalEnt136302_2369.

Phylogenomic databases

eggNOGi COG0380.
OMAi WGESFVK.
OrthoDBi EOG6CCH1M.

Enzyme and pathway databases

UniPathwayi UPA00299 .
BioCyci SENT321314:GJCS-2024-MONOMER.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02400. trehalose_OtsA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiOTSA_SALCH
AccessioniPrimary (citable) accession number: Q57N70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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