Reviewed, UniProtKB/Swiss-Prot Q57M97 (CCMA1_SALCH)

Names and origin

Protein names

Recommended name:
    Cytochrome c biogenesis ATP-binding export protein ccmA 1
    EC=3.6.3.41
Alternative name(s):
    Heme exporter protein A 1

Gene names

Name:	ccmA1
Ordered Locus Names:	SCH_2259

Organism

Salmonella choleraesuis [Complete proteome] [HAMAP]

Taxonomic identifier

28901 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex ccmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (ccmA) and two transmembrane proteins (ccmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: HAMAP
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Cytochrome c biogenesis ATP-binding export protein ccmA 1 HAMAP MF_01707		PRO_0000238787
Regions
	Domain	2 – 205	204	ABC transporter
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57M97-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 8910F77131520049	FASTA	205	22,350
	10 20 30 40 50 60 MLEARDLYCE RDERTLFRGL SFTVDAGEWV QVTGGNGAGK TTLLRLLTGL ARPDGGEVYW 70 80 90 100 110 120 QGEPLRRVRD SFHRSLLWIG HQPGIKTRLT ARENLHFFHP GDGARLPEAL AQAGLAGFED 130 140 150 160 170 180 VPVARLSAGQ QRRVALARLW LTRAALWVLD EPFTAIDVNG VARLTRRMAA HTAQGGMVIL 190 200 TTHQPLPGAA DTVRRLALTG GGAGL

References

[1]

"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen." Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S. Nucleic Acids Res. 33:1690-1698(2005) [PubMed: 15781495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC-B67.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017220 Genomic DNA. Translation: AAX66165.1.
RefSeq	YP_217246.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3334748.
GenomeReviews	Gene locus SCH_2259 in contig AE017220_GR.
KEGG	sec:SC2259.
NMPDR	fig|321314.4.peg.2635.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57M97.
OMA	QTGVKRE.
Enzyme and pathway databases
BioCyc	SENT321314:SCH_2259-MON.
BRENDA	3.6.3.41. 276841.
Family and domain databases
HAMAP	MF_01707. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
PANTHER	PTHR19222:SF5. CcmA. 1 hit.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
ProDom	PD000006. ABC_transporter. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. ccmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA1_SALCH

Accession

Primary (citable) accession number: Q57M97

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 10, 2005
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)