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Q57LL0

- PUR5_SALCH

UniProt

Q57LL0 - PUR5_SALCH

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, SCH_2496
Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT321314:GJCS-2611-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:SCH_2496
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 345344Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000258400Add
BLAST

Proteomic databases

PaxDbiQ57LL0.

Interactioni

Protein-protein interaction databases

STRINGi321314.SC2496.

Structurei

3D structure databases

ProteinModelPortaliQ57LL0.
SMRiQ57LL0. Positions 5-345.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q57LL0-1 [UniParc]FASTAAdd to Basket

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MTDKTSLSYK DAGVDIDAGN ALVDRIKGVV KKTRRPEVMG GLGGFGALCA    50
LPQKYREPVL VSGTDGVGTK LRLAMDLKRH DAIGIDLVAM CVNDLVVQGA 100
EPLFFLDYYA TGKLDVDTAA SVINGIAEGC LQSGCALVGG ETAEMPGMYH 150
GEDYDVAGFC VGVVEKSEII DGSRVAEGDV LIALGSSGPH SNGYSLVRKI 200
IDVSGCDPQT TLLEGKPLAD HLLEPTRIYV KSVLELIENI DVHAIAHLTG 250
GGFWENIPRV LPENTQAVIN ESSWQWPAIF TWLQTAGNVS RHEMYRTFNC 300
GVGMVIALSA PEADKALALL NEKGENAWKI GIIKASDSEQ RVVIE 345
Length:345
Mass (Da):36,914
Last modified:January 23, 2007 - v3
Checksum:i1EB870423A0B5339
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX66402.1.
RefSeqiYP_217483.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX66402; AAX66402; SCH_2496.
PATRICi32326014. VBISalEnt136302_2978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX66402.1 .
RefSeqi YP_217483.1. NC_006905.1.

3D structure databases

ProteinModelPortali Q57LL0.
SMRi Q57LL0. Positions 5-345.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321314.SC2496.

Proteomic databases

PaxDbi Q57LL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX66402 ; AAX66402 ; SCH_2496 .
PATRICi 32326014. VBISalEnt136302_2978.

Phylogenomic databases

eggNOGi COG0150.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SENT321314:GJCS-2611-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiPUR5_SALCH
AccessioniPrimary (citable) accession number: Q57LL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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