Putative bifunctional cytochrome c-type biogenesis protein CcmAE

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Q57I19 (CCMAE_SALCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Putative bifunctional cytochrome c-type biogenesis protein CcmAE

Including the following 2 domains:

Cytochrome c biogenesis ATP-binding export protein CcmA 2
EC=3.6.3.41
Alternative name(s):
Heme exporter protein A 2
Cytochrome c-type biogenesis protein CcmE 2
Alternative name(s):
Cytochrome c maturation protein E 2
Heme chaperone CcmE 2

Gene names

Name:	ccmAE
Synonyms:	ccmA2, ccmE2
Ordered Locus Names:	SCH_3737

Organism

Salmonella choleraesuis [Complete proteome] [HAMAP]

Taxonomic identifier

28901 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP MF_01707
Catalytic activity	ATP + H₂O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subcellular location	Cell inner membrane; Peripheral membrane protein Potential HAMAP MF_01707.
Sequence similarities	In the N-terminal section; belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] In the C-terminal section; belongs to the CcmE/CycJ family. Contains 1 ABC transporter domain.
Caution	This sequence is a fusion of the duplicated copies ccmA2 and ccmE2, however, important parts of the proteins are missing and it is therefore probably not functional. Could be the product of a pseudogene.
Sequence caution	The sequence AAX67643.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Heme Iron Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW protein-heme linkage Inferred from electronic annotation. Source: InterPro
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 336

336

Putative bifunctional cytochrome c-type biogenesis protein CcmAE HAMAP MF_01707

PRO_0000238860

Regions

Domain

2 – 242

241

ABC transporter

Nucleotide binding

34 – 41

ATP Potential

Region

1 – 199

199

Cytochrome c biogenesis ATP-binding export protein CcmA 2 HAMAP MF_01707

Region

196 – 336

141

Cytochrome c-type biogenesis protein CcmE 2 HAMAP MF_01707

Sites

Metal binding

311

Iron (heme axial ligand) By similarity

Binding site

307

Heme (covalent; via pros nitrogen) By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q57I19 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: 26E359D6F50FB952
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FASTA

336

37,197

        10         20         30         40         50         60 
MLEARDLYCE RDERTLFRGL SFTVDAGEWV QVTGGNGAGK TTLLRLLTGL ARPDGGEVYW 

        70         80         90        100        110        120 
QGEPLRRVRD SFHRSLLWIG HQPGIKTRLT ARENLHFFHP GDGARLPEAL AQAGLAGFED 

       130        140        150        160        170        180 
VPVARLSAGQ QRRVALARLW LTRAALWVLD EPFTAIDVNG VARLTRRMAA HTAQGGMVIL 

       190        200        210        220        230        240 
TTHQPLPGAA DTVRRLALTT ALVLYALRAN IDLFYTPGEI LYGKRETQQL PAVGQRLRVG 

       250        260        270        280        290        300 
GMVMPGSVRR DPDSLKVNFS LYDAEGSVTV SYEGILPDLF REGQGVVVQG TLEKGNHVLA 

       310        320        330 
HEVLAKHDEN YTPPEVEKAM QENHRRPQRV DKDTSS

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References

[1]

"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
Nucleic Acids Res. 33:1690-1698(2005) [PubMed: 15781495] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC-B67.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017220 Genomic DNA. Translation: AAX67643.1. Different initiation.
3D structure databases
ProteinModelPortal	Q57I19.
SMR	Q57I19. Positions 207-320.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus SCH_3737 in contig AE017220_GR.
KEGG	sec:SC3737.
NMPDR	fig\|321314.4.peg.3955.
PATRIC	32328754. VBISalEnt136302_4320.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG758042.
PhylomeDB	Q57I19.
Enzyme and pathway databases
BioCyc	SENT321314:SCH_3737-MONOMER.
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. Fused. [Tree] MF_01959. CcmE. Fused. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. IPR004329. CcmE. IPR012340. NA-bd_OB-fold. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K02193.
Pfam	PF00005. ABC_tran. 1 hit. PF03100. CcmE. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF82093. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMAE_SALCH

Accession

Primary (citable) accession number: Q57I19

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	May 30, 2006
Last modified:	January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Including the following 2 domains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents