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Protein

Putative bifunctional cytochrome c-type biogenesis protein CcmAE

Gene

ccmAE

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity).By similarity
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).By similarity

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei307Heme (covalent; via pros nitrogen)By similarity1
Metal bindingi311Iron (heme axial ligand)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 41ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCytochrome c-type biogenesis, Transport
LigandATP-binding, Heme, Iron, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative bifunctional cytochrome c-type biogenesis protein CcmAE
Including the following 2 domains:
Cytochrome c biogenesis ATP-binding export protein CcmA 2 (EC:3.6.3.41)
Alternative name(s):
Heme exporter protein A 2
Cytochrome c-type biogenesis protein CcmE 2
Alternative name(s):
Cytochrome c maturation protein E 2
Heme chaperone CcmE 2
Gene namesi
Name:ccmAE
Synonyms:ccmA2, ccmE2
Ordered Locus Names:SCH_3737
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000000538 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388601 – 336Putative bifunctional cytochrome c-type biogenesis protein CcmAEAdd BLAST336

Structurei

3D structure databases

ProteinModelPortaliQ57I19.
SMRiQ57I19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 242ABC transporterAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 199Cytochrome c biogenesis ATP-binding export protein CcmA 2Add BLAST199
Regioni196 – 336Cytochrome c-type biogenesis protein CcmE 2Add BLAST141

Sequence similaritiesi

In the N-terminal section; belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]Curated
In the C-terminal section; belongs to the CcmE/CycJ family.Curated

Phylogenomic databases

KOiK02193.

Family and domain databases

HAMAPiMF_01959. CcmE. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR004329. CcmE.
IPR036127. CcmE-like_sf.
IPR027417. P-loop_NTPase.
PANTHERiPTHR43499. PTHR43499. 1 hit.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
PF03100. CcmE. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF82093. SSF82093. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57I19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEARDLYCE RDERTLFRGL SFTVDAGEWV QVTGGNGAGK TTLLRLLTGL
60 70 80 90 100
ARPDGGEVYW QGEPLRRVRD SFHRSLLWIG HQPGIKTRLT ARENLHFFHP
110 120 130 140 150
GDGARLPEAL AQAGLAGFED VPVARLSAGQ QRRVALARLW LTRAALWVLD
160 170 180 190 200
EPFTAIDVNG VARLTRRMAA HTAQGGMVIL TTHQPLPGAA DTVRRLALTT
210 220 230 240 250
ALVLYALRAN IDLFYTPGEI LYGKRETQQL PAVGQRLRVG GMVMPGSVRR
260 270 280 290 300
DPDSLKVNFS LYDAEGSVTV SYEGILPDLF REGQGVVVQG TLEKGNHVLA
310 320 330
HEVLAKHDEN YTPPEVEKAM QENHRRPQRV DKDTSS
Length:336
Mass (Da):37,197
Last modified:May 30, 2006 - v2
Checksum:i26E359D6F50FB952
GO

Sequence cautioni

The sequence AAX67643 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX67643.1. Different initiation.
RefSeqiWP_024131381.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX67643; AAX67643; SCH_3737.
KEGGisec:SCH_3737.

Similar proteinsi

Entry informationi

Entry nameiCCMAE_SALCH
AccessioniPrimary (citable) accession number: Q57I19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 22, 2017
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This sequence is a fusion of the duplicated copies ccmA2 and ccmE2, however, important parts of the proteins are missing and it is therefore probably not functional.Curated
Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families