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Protein

D-galactonate dehydratase

Gene

dgoD

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.UniRule annotation

Catalytic activityi

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: D-galactonate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. D-galactonate dehydratase (dgoD)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway D-galactonate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate, the pathway D-galactonate degradation and in Carbohydrate acid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183MagnesiumUniRule annotation1
Active sitei185Proton donorBy similarity1
Metal bindingi209MagnesiumUniRule annotation1
Metal bindingi235MagnesiumUniRule annotation1
Sitei258Increases basicity of active site HisUniRule annotation1
Active sitei285Proton acceptorBy similarity1
Sitei310Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00081; UER00518.

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydrataseUniRule annotation (EC:4.2.1.6UniRule annotation)
Short name:
GalDUniRule annotation
Gene namesi
Name:dgoDUniRule annotation
Ordered Locus Names:SCH_3745
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000000538 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003526331 – 382D-galactonate dehydrataseAdd BLAST382

Structurei

3D structure databases

ProteinModelPortaliQ57I11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.UniRule annotation

Phylogenomic databases

KOiK01684.
OMAiHARMRNW.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57I11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKITHITTYR LPPRWMFLKI ETDEGVVGWG EPVIESRART VEAAVHEFAD
60 70 80 90 100
YLIGKDPARI NDLWQVMYRA GFYRGGPIMM SAIAGIDQAL WDIKGKVLNA
110 120 130 140 150
PVWQLMGGLV RDKIKAYSWV GGDRPADVID GIEKLRGIGF DTFKLNGCEE
160 170 180 190 200
MGVIDNSRAV DAAVNTVAQI REAFGSEIEF GLDFHGRVSA PMAKVLIKEL
210 220 230 240 250
EPYRPLFIEE PVLAEQAEYY PRLAAQTHIP IAAGERMFSR FEFKRVLDAG
260 270 280 290 300
GLAILQPDLS HAGGITECYK IAGMAEAYDV ALAPHCPLGP IALAACLHID
310 320 330 340 350
FVSRNAVFQE QSMGIHYNKG AELLDFVKNK EDFSMDGGFF KPLTKPGLGV
360 370 380
DIDEARVIEL SKSAPDWRNP LWRHADGSVA EW
Length:382
Mass (Da):42,409
Last modified:May 10, 2005 - v1
Checksum:iF59896248E4865BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
KEGGisec:SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.

3D structure databases

ProteinModelPortaliQ57I11.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
KEGGisec:SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Phylogenomic databases

KOiK01684.
OMAiHARMRNW.

Enzyme and pathway databases

UniPathwayiUPA00081; UER00518.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGOD_SALCH
AccessioniPrimary (citable) accession number: Q57I11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via an anti dehydration.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.