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Q57I11 (DGOD_SALCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-galactonate dehydratase

Short name=GalD
EC=4.2.1.6
Gene names
Name:dgoD
Ordered Locus Names:SCH_3745
OrganismSalmonella choleraesuis (strain SC-B67) [Complete proteome] [HAMAP]
Taxonomic identifier321314 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate By similarity. HAMAP-Rule MF_01289

Catalytic activity

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. HAMAP-Rule MF_01289

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01289

Pathway

Carbohydrate acid metabolism; D-galactonate degradation; D-glyceraldehyde 3-phosphate and pyruvate from D-galactonate: step 1/3. HAMAP-Rule MF_01289

Miscellaneous

Reaction proceeds via an anti dehydration By similarity.

Sequence similarities

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-galactonate catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cellular amino acid catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiongalactonate dehydratase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382D-galactonate dehydratase HAMAP-Rule MF_01289
PRO_0000352633

Sites

Active site1851Proton donor By similarity
Active site2851Proton acceptor By similarity
Metal binding1831Magnesium By similarity
Metal binding2091Magnesium By similarity
Metal binding2351Magnesium By similarity
Site2581Increases basicity of active site His By similarity
Site3101Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57I11 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: F59896248E4865BC

FASTA38242,409
        10         20         30         40         50         60 
MKITHITTYR LPPRWMFLKI ETDEGVVGWG EPVIESRART VEAAVHEFAD YLIGKDPARI 

        70         80         90        100        110        120 
NDLWQVMYRA GFYRGGPIMM SAIAGIDQAL WDIKGKVLNA PVWQLMGGLV RDKIKAYSWV 

       130        140        150        160        170        180 
GGDRPADVID GIEKLRGIGF DTFKLNGCEE MGVIDNSRAV DAAVNTVAQI REAFGSEIEF 

       190        200        210        220        230        240 
GLDFHGRVSA PMAKVLIKEL EPYRPLFIEE PVLAEQAEYY PRLAAQTHIP IAAGERMFSR 

       250        260        270        280        290        300 
FEFKRVLDAG GLAILQPDLS HAGGITECYK IAGMAEAYDV ALAPHCPLGP IALAACLHID 

       310        320        330        340        350        360 
FVSRNAVFQE QSMGIHYNKG AELLDFVKNK EDFSMDGGFF KPLTKPGLGV DIDEARVIEL 

       370        380 
SKSAPDWRNP LWRHADGSVA EW 

« Hide

References

[1]"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC-B67.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqYP_218732.1. NC_006905.1.

3D structure databases

ProteinModelPortalQ57I11.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321314.SC3745.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX67651; AAX67651; SCH_3745.
PATRIC32328776. VBISalEnt136302_4331.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4948.
OMACIKMNAT.
OrthoDBEOG6C015P.
ProtClustDBPRK14017.

Enzyme and pathway databases

BioCycSENT321314:GJCS-3906-MONOMER.
UniPathwayUPA00081; UER00518.

Family and domain databases

HAMAPMF_01289. Galacton_dehydrat.
InterProIPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view]
PANTHERPTHR13794. PTHR13794. 1 hit.
PfamPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTSM00922. MR_MLE. 1 hit.
[Graphical view]
PROSITEPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDGOD_SALCH
AccessionPrimary (citable) accession number: Q57I11
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 10, 2005
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways