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Q57I11

- DGOD_SALCH

UniProt

Q57I11 - DGOD_SALCH

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Protein
D-galactonate dehydratase
Gene
dgoD, SCH_3745
Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate By similarity.UniRule annotation

Catalytic activityi

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831Magnesium By similarity
Active sitei185 – 1851Proton donor By similarity
Metal bindingi209 – 2091Magnesium By similarity
Metal bindingi235 – 2351Magnesium By similarity
Sitei258 – 2581Increases basicity of active site His By similarity
Active sitei285 – 2851Proton acceptor By similarity
Sitei310 – 3101Transition state stabilizer By similarity

GO - Molecular functioni

  1. galactonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-galactonate catabolic process Source: UniProtKB-HAMAP
  2. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT321314:GJCS-3906-MONOMER.
UniPathwayiUPA00081; UER00518.

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydratase (EC:4.2.1.6)
Short name:
GalD
Gene namesi
Name:dgoD
Ordered Locus Names:SCH_3745
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382D-galactonate dehydrataseUniRule annotation
PRO_0000352633Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321314.SC3745.

Structurei

3D structure databases

ProteinModelPortaliQ57I11.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4948.
OMAiPWQCKEF.
OrthoDBiEOG6C015P.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57I11-1 [UniParc]FASTAAdd to Basket

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MKITHITTYR LPPRWMFLKI ETDEGVVGWG EPVIESRART VEAAVHEFAD    50
YLIGKDPARI NDLWQVMYRA GFYRGGPIMM SAIAGIDQAL WDIKGKVLNA 100
PVWQLMGGLV RDKIKAYSWV GGDRPADVID GIEKLRGIGF DTFKLNGCEE 150
MGVIDNSRAV DAAVNTVAQI REAFGSEIEF GLDFHGRVSA PMAKVLIKEL 200
EPYRPLFIEE PVLAEQAEYY PRLAAQTHIP IAAGERMFSR FEFKRVLDAG 250
GLAILQPDLS HAGGITECYK IAGMAEAYDV ALAPHCPLGP IALAACLHID 300
FVSRNAVFQE QSMGIHYNKG AELLDFVKNK EDFSMDGGFF KPLTKPGLGV 350
DIDEARVIEL SKSAPDWRNP LWRHADGSVA EW 382
Length:382
Mass (Da):42,409
Last modified:May 10, 2005 - v1
Checksum:iF59896248E4865BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1 .
RefSeqi WP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

3D structure databases

ProteinModelPortali Q57I11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321314.SC3745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX67651 ; AAX67651 ; SCH_3745 .
PATRICi 32328776. VBISalEnt136302_4331.

Phylogenomic databases

eggNOGi COG4948.
OMAi PWQCKEF.
OrthoDBi EOG6C015P.

Enzyme and pathway databases

UniPathwayi UPA00081 ; UER00518 .
BioCyci SENT321314:GJCS-3906-MONOMER.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_01289. Galacton_dehydrat.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiDGOD_SALCH
AccessioniPrimary (citable) accession number: Q57I11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via an anti dehydration By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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