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Protein

D-galactonate dehydratase

Gene

dgoD

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.UniRule annotation

Catalytic activityi

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831MagnesiumUniRule annotation
Active sitei185 – 1851Proton donorBy similarity
Metal bindingi209 – 2091MagnesiumUniRule annotation
Metal bindingi235 – 2351MagnesiumUniRule annotation
Sitei258 – 2581Increases basicity of active site HisUniRule annotation
Active sitei285 – 2851Proton acceptorBy similarity
Sitei310 – 3101Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. galactonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular amino acid catabolic process Source: InterPro
  2. D-galactonate catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT321314:GJCS-3906-MONOMER.
UniPathwayiUPA00081; UER00518.

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydrataseUniRule annotation (EC:4.2.1.6UniRule annotation)
Short name:
GalDUniRule annotation
Gene namesi
Name:dgoDUniRule annotation
Ordered Locus Names:SCH_3745
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382D-galactonate dehydratasePRO_0000352633Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321314.SC3745.

Structurei

3D structure databases

ProteinModelPortaliQ57I11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4948.
OMAiSVYAWIG.
OrthoDBiEOG6C015P.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57I11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKITHITTYR LPPRWMFLKI ETDEGVVGWG EPVIESRART VEAAVHEFAD
60 70 80 90 100
YLIGKDPARI NDLWQVMYRA GFYRGGPIMM SAIAGIDQAL WDIKGKVLNA
110 120 130 140 150
PVWQLMGGLV RDKIKAYSWV GGDRPADVID GIEKLRGIGF DTFKLNGCEE
160 170 180 190 200
MGVIDNSRAV DAAVNTVAQI REAFGSEIEF GLDFHGRVSA PMAKVLIKEL
210 220 230 240 250
EPYRPLFIEE PVLAEQAEYY PRLAAQTHIP IAAGERMFSR FEFKRVLDAG
260 270 280 290 300
GLAILQPDLS HAGGITECYK IAGMAEAYDV ALAPHCPLGP IALAACLHID
310 320 330 340 350
FVSRNAVFQE QSMGIHYNKG AELLDFVKNK EDFSMDGGFF KPLTKPGLGV
360 370 380
DIDEARVIEL SKSAPDWRNP LWRHADGSVA EW
Length:382
Mass (Da):42,409
Last modified:May 10, 2005 - v1
Checksum:iF59896248E4865BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

3D structure databases

ProteinModelPortaliQ57I11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi321314.SC3745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Phylogenomic databases

eggNOGiCOG4948.
OMAiSVYAWIG.
OrthoDBiEOG6C015P.

Enzyme and pathway databases

UniPathwayiUPA00081; UER00518.
BioCyciSENT321314:GJCS-3906-MONOMER.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiDGOD_SALCH
AccessioniPrimary (citable) accession number: Q57I11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via an anti dehydration.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.