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Q57I11

- DGOD_SALCH

UniProt

Q57I11 - DGOD_SALCH

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Protein

D-galactonate dehydratase

Gene

dgoD

Organism
Salmonella choleraesuis (strain SC-B67)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy-D-galactonate.UniRule annotation

Catalytic activityi

D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi183 – 1831MagnesiumUniRule annotation
Active sitei185 – 1851Proton donorBy similarity
Metal bindingi209 – 2091MagnesiumUniRule annotation
Metal bindingi235 – 2351MagnesiumUniRule annotation
Sitei258 – 2581Increases basicity of active site HisUniRule annotation
Active sitei285 – 2851Proton acceptorBy similarity
Sitei310 – 3101Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. galactonate dehydratase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular amino acid catabolic process Source: InterPro
  2. D-galactonate catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSENT321314:GJCS-3906-MONOMER.
UniPathwayiUPA00081; UER00518.

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydrataseUniRule annotation (EC:4.2.1.6UniRule annotation)
Short name:
GalDUniRule annotation
Gene namesi
Name:dgoDUniRule annotation
Ordered Locus Names:SCH_3745
OrganismiSalmonella choleraesuis (strain SC-B67)
Taxonomic identifieri321314 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000538: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382D-galactonate dehydratasePRO_0000352633Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321314.SC3745.

Structurei

3D structure databases

ProteinModelPortaliQ57I11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG4948.
OMAiPWQCKEF.
OrthoDBiEOG6C015P.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01289. Galacton_dehydrat.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57I11 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKITHITTYR LPPRWMFLKI ETDEGVVGWG EPVIESRART VEAAVHEFAD
60 70 80 90 100
YLIGKDPARI NDLWQVMYRA GFYRGGPIMM SAIAGIDQAL WDIKGKVLNA
110 120 130 140 150
PVWQLMGGLV RDKIKAYSWV GGDRPADVID GIEKLRGIGF DTFKLNGCEE
160 170 180 190 200
MGVIDNSRAV DAAVNTVAQI REAFGSEIEF GLDFHGRVSA PMAKVLIKEL
210 220 230 240 250
EPYRPLFIEE PVLAEQAEYY PRLAAQTHIP IAAGERMFSR FEFKRVLDAG
260 270 280 290 300
GLAILQPDLS HAGGITECYK IAGMAEAYDV ALAPHCPLGP IALAACLHID
310 320 330 340 350
FVSRNAVFQE QSMGIHYNKG AELLDFVKNK EDFSMDGGFF KPLTKPGLGV
360 370 380
DIDEARVIEL SKSAPDWRNP LWRHADGSVA EW
Length:382
Mass (Da):42,409
Last modified:May 10, 2005 - v1
Checksum:iF59896248E4865BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1.
RefSeqiWP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

Genome annotation databases

EnsemblBacteriaiAAX67651; AAX67651; SCH_3745.
PATRICi32328776. VBISalEnt136302_4331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017220 Genomic DNA. Translation: AAX67651.1 .
RefSeqi WP_001541161.1. NC_006905.1.
YP_218732.1. NC_006905.1.

3D structure databases

ProteinModelPortali Q57I11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321314.SC3745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX67651 ; AAX67651 ; SCH_3745 .
PATRICi 32328776. VBISalEnt136302_4331.

Phylogenomic databases

eggNOGi COG4948.
OMAi PWQCKEF.
OrthoDBi EOG6C015P.

Enzyme and pathway databases

UniPathwayi UPA00081 ; UER00518 .
BioCyci SENT321314:GJCS-3906-MONOMER.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_01289. Galacton_dehydrat.
InterProi IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR023592. Galactonate_deHydtase.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
PS00909. MR_MLE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
    Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
    Nucleic Acids Res. 33:1690-1698(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC-B67.

Entry informationi

Entry nameiDGOD_SALCH
AccessioniPrimary (citable) accession number: Q57I11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Reaction proceeds via an anti dehydration.UniRule annotation

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3