Q57H91 (STHA_SALCH) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Soluble pyridine nucleotide transhydrogenase Short name=STH EC=1.6.1.1 Alternative name(s): NAD(P)(+) transhydrogenase [B-specific] | ||||||
| Gene names |
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| Organism | Salmonella choleraesuis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 28901 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247 |
| Catalytic activity | NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247 |
| Cofactor | Binds 1 FAD per subunit By similarity. HAMAP MF_00247 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00247. |
| Sequence similarities | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247 | PRO_0000260242 | |||||
Regions | |||||||||
| Nucleotide binding | 36 – 45 | 10 | FAD By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen." Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S. Nucleic Acids Res. 33:1690-1698(2005) [PubMed: 15781495] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC-B67. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017220 Genomic DNA. Translation: AAX67921.1. |
| RefSeq | YP_219002.1. NC_006905.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2F5Z based on UniProtKB P09622. |
| ProteinModelPortal | Q57H91. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 3336556. |
| GenomeReviews | Gene locus SCH_4015 in contig AE017220_GR. |
| KEGG | sec:SC4015. |
| NMPDR | fig|321314.4.peg.3740. |
| PATRIC | 32329411. VBISalEnt136302_4630. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG515043. |
| OMA | GEGNTIE. |
| PhylomeDB | Q57H91. |
| ProtClustDB | PRK05249. |
Enzyme and pathway databases | |
| BioCyc | SENT321314:SCH_4015-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00247. SthA. [Tree] |
| InterPro | IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR022962. STH. [Graphical view] |
| Gene3D | G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit. |
| KO | K00322. |
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. |
| SUPFAM | SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | STHA_SALCH | ||||||||
| Accession | Primary (citable) accession number: Q57H91 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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