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Q57GQ5 (DSBD_SALCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiol:disulfide interchange protein DsbD
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase
Short name=Disulfide reductase
Gene names
Name:dsbD
Ordered Locus Names:SCH_4201
OrganismSalmonella choleraesuis [Complete proteome] [HAMAP]
Taxonomic identifier28901 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity. HAMAP MF_00399

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00399.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 567548Thiol:disulfide interchange protein DsbD HAMAP MF_00399
PRO_0000304394

Regions

Transmembrane166 – 18621Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane299 – 31921Helical; Potential
Transmembrane326 – 34621Helical; Potential
Transmembrane360 – 38021Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane418 – 43821Helical; Potential
Domain435 – 567133Thioredoxin

Amino acid modifications

Disulfide bond122 ↔ 128Redox-active By similarity
Disulfide bond185 ↔ 307Redox-active By similarity
Disulfide bond482 ↔ 485Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57GQ5 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 5793C898C41612E2

FASTA56761,142
        10         20         30         40         50         60 
MAQRIFTLIL LLCSTSAFAG LFDAPGRSQF VPADRAFVFD FQQNQHDLTL SWQVKEGYYL 

        70         80         90        100        110        120 
YRKQISITPT KADIAAVQLP AGVWHEDEFY GKSEIYRKRL NVPVTVNQAA AGATLTVTYQ 

       130        140        150        160        170        180 
GCADAGFCYP PETKTVPLSE VAAAIDATPT PAVTQTGETS KPAAQLPFSA LWALLIGIGI 

       190        200        210        220        230        240 
AFTPCVLPMY PLISGIVLGG RQRLSTGRAL LLAFIYVQGM ALTYTALGLV AAAAGLQFQA 

       250        260        270        280        290        300 
ALQHPYVLIG LAIVFTLLAL SMFGLFTLQL PSSLQTRLTL MSNRQQGGSP GGVFVMGAIA 

       310        320        330        340        350        360 
GLICSPCTTA PLSAILLYIA QSGNMWLGGG TLYLYALGMG LPLMLVTVFG NRLLPKSGPW 

       370        380        390        400        410        420 
MAHVKTAFGF VILALPVFLL ERIIGEAWGL RLWSLLGVAF FGWAFITSLQ ARRAGMRIVQ 

       430        440        450        460        470        480 
IILLAAALIS VRPLQDWAFG SPSAQAPAHL NFTAISTVDE LNQALAQAKG NPVMLDFYAD 

       490        500        510        520        530        540 
WCVACKEFEK YTFSDPRVQQ ALGDTVLLQA NVTANNAQDV ALLKHLQVLG LPTILFFDAQ 

       550        560 
GQEQPQARVT GFMDAATFSA HLHDRQP

« Hide

References

[1]"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen."
Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.
Nucleic Acids Res. 33:1690-1698(2005) [PubMed: 15781495] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC-B67.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017220 Genomic DNA. Translation: AAX68107.1.
RefSeqYP_219188.1. NC_006905.1.

3D structure databases

HSSPHSSP built from PDB template 1VRS based on UniProtKB P36655.
ProteinModelPortalQ57GQ5.
SMRQ57GQ5. Positions 20-143, 449-567.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3336750.
GenomeReviewsGene locus SCH_4201 in contig AE017220_GR.
KEGGsec:SC4201.
NMPDRfig|321314.4.peg.4257.
PATRIC32329827. VBISalEnt136302_4827.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG640883.
OMATHILWAG.
PhylomeDBQ57GQ5.
ProtClustDBPRK00293.

Enzyme and pathway databases

BioCycSENT321314:SCH_4201-MONOMER.

Family and domain databases

HAMAPMF_00399. DbsD.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM_dom.
IPR022910. Thiol_diS_interchange_DbsD.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK04084.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBD_SALCH
AccessionPrimary (citable) accession number: Q57GQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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