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Q57FU7

- DNAE2_BRUAB

UniProt

Q57FU7 - DNAE2_BRUAB

Protein

Error-prone DNA polymerase

Gene

dnaE2

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.UniRule annotation

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: InterPro
    2. DNA binding Source: InterPro
    3. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair, DNA replication

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-70-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Error-prone DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
    Gene namesi
    Name:dnaE2UniRule annotation
    Ordered Locus Names:BruAb1_0069
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10771077Error-prone DNA polymerasePRO_0000103370Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57FU7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0587.
    HOGENOMiHOG000021783.
    KOiK14162.
    OMAiCECITQA.
    OrthoDBiEOG6CZQGR.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01902. DNApol_error_prone.
    InterProiIPR011708. DNA_pol3_alpha.
    IPR023073. DNA_pol_error_prone.
    IPR029460. DNAPol_HHH.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view]
    PfamiPF07733. DNA_pol3_alpha. 1 hit.
    PF14579. HHH_6. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view]
    SMARTiSM00481. POLIIIAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 2 hits.
    TIGRFAMsiTIGR00594. polc. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q57FU7-1 [UniParc]FASTAAdd to Basket

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    MVPYFEMAAA SNFSFLCGAS HPQELVERAH ALDLSGIGIA DRNTLAGVVR     50
    AHAQWKDIRK ESGFRLFIGC RLSFIDGTPD MVVYPRDRAA YGQLCRLLTE 100
    GKHRAAIKGE CHLEWADLLF RARQFQIAVF PPDEDEPDFA ARLTEIAQAA 150
    PGSVWLALTM PHQGQDGRRA ERIARFAAQA GVPLIATNDV LYHHPDRRPL 200
    QDVLTATRHH TTVFAAGRLL EKNAERHLKP PHEMVRLFRD YPEAIAATAD 250
    FVAPITFQLD ELKYAYPDEP IPPGKTAQQH LYDLVWEGAA RHYGADMIPP 300
    KVQGLINKEL ALIARLEYEP YFLTVYDIVT HAREKGILCQ GRGSAANSVV 350
    CFCLGITGVN PTQVDLLFER FISAERKEPP DIDVDFEHER REEVMQYVYD 400
    RYSRDRAAIV ATVISYRSRS AIRDVGKALG LSEDVTAALA NTVWGLSGGG 450
    IDRQHIRQAG LDPDNPIIQR AVELAITLIG FPRHLSQHVG GFVLTRDRLD 500
    ETVPIGPAAM DKRSFIEWDK DDIDEVGLMK VDVLSLGMLT CIRKAFDLIH 550
    QHKPQLYGGE KLTLASLPRK DKAVYDMLCK GDSLGVFQVE SRAQMNMLPR 600
    LRPQEFYDLV IEVAIVRPGP IQGDMVHPYL RRRSGQEPCT LPSPSPQHGP 650
    ANELQQILGK TKGVPLFQEQ AMRIAMEAAK FTPEEANQLR RAMATFRKMG 700
    TIHTMEKKMI DGMVNRGYDR TFAENCFNQI KGFGEYGFPE SHAASFAHLV 750
    YISAWLKCHH PEVFAAALLN SQPMGFYAPA QIVRDAREHG VTVLPVDVNF 800
    SQWDNILEET PDVHLALRLG FRQIDGFSKR DTELLIADRQ EPYRTIEDMH 850
    RRLRLDRRAF TLLADADAFG SLDIDRRAAL WAVRRLPNDE TLPLFRAAAA 900
    SELAQEPRTK LPEMAASEHV IADYETTRLS LKGHPLQYLR EGLAAEGVST 950
    CRAVQEGADG RRMKVAGVVT VRQRPGSAKG VVFLTIEDET GIANIVIWPK 1000
    IMKVFRREVM SARLIHIEGR IQRSLEGVVH LVAAKLQDRS AALIEMSGRE 1050
    AQRLIAPSQM AHHPRNVRVM PNSRDFH 1077
    Length:1,077
    Mass (Da):120,966
    Last modified:May 10, 2005 - v1
    Checksum:i174FFECD599A8B3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73487.1.
    RefSeqiYP_220848.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73487; AAX73487; BruAb1_0069.
    GeneIDi3339320.
    KEGGibmb:BruAb1_0069.
    PATRICi17821659. VBIBruAbo15061_0074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73487.1 .
    RefSeqi YP_220848.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57FU7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0069.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73487 ; AAX73487 ; BruAb1_0069 .
    GeneIDi 3339320.
    KEGGi bmb:BruAb1_0069.
    PATRICi 17821659. VBIBruAbo15061_0074.

    Phylogenomic databases

    eggNOGi COG0587.
    HOGENOMi HOG000021783.
    KOi K14162.
    OMAi CECITQA.
    OrthoDBi EOG6CZQGR.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-70-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01902. DNApol_error_prone.
    InterProi IPR011708. DNA_pol3_alpha.
    IPR023073. DNA_pol_error_prone.
    IPR029460. DNAPol_HHH.
    IPR012340. NA-bd_OB-fold.
    IPR004365. NA-bd_OB_tRNA.
    IPR003141. Pol/His_phosphatase_N.
    IPR016195. Pol/histidinol_Pase-like.
    IPR004805. PolC_alpha.
    [Graphical view ]
    Pfami PF07733. DNA_pol3_alpha. 1 hit.
    PF14579. HHH_6. 1 hit.
    PF01336. tRNA_anti-codon. 1 hit.
    [Graphical view ]
    SMARTi SM00481. POLIIIAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 2 hits.
    TIGRFAMsi TIGR00594. polc. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiDNAE2_BRUAB
    AccessioniPrimary (citable) accession number: Q57FU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3