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Protein

Error-prone DNA polymerase

Gene

dnaE2

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: InterPro
  3. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA repair Source: UniProtKB-HAMAP
  2. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciBABO262698:GJC2-70-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Error-prone DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:dnaE2UniRule annotation
Ordered Locus Names:BruAb1_0069
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10771077Error-prone DNA polymerasePRO_0000103370Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_0069.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-C family. DnaE2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0587.
HOGENOMiHOG000021783.
KOiK14162.
OMAiERTVIQW.
OrthoDBiEOG6CZQGR.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01902. DNApol_error_prone.
InterProiIPR011708. DNA_pol3_alpha.
IPR023073. DNA_pol_error_prone.
IPR029460. DNAPol_HHH.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
PfamiPF07733. DNA_pol3_alpha. 1 hit.
PF14579. HHH_6. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 2 hits.
TIGRFAMsiTIGR00594. polc. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57FU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPYFEMAAA SNFSFLCGAS HPQELVERAH ALDLSGIGIA DRNTLAGVVR
60 70 80 90 100
AHAQWKDIRK ESGFRLFIGC RLSFIDGTPD MVVYPRDRAA YGQLCRLLTE
110 120 130 140 150
GKHRAAIKGE CHLEWADLLF RARQFQIAVF PPDEDEPDFA ARLTEIAQAA
160 170 180 190 200
PGSVWLALTM PHQGQDGRRA ERIARFAAQA GVPLIATNDV LYHHPDRRPL
210 220 230 240 250
QDVLTATRHH TTVFAAGRLL EKNAERHLKP PHEMVRLFRD YPEAIAATAD
260 270 280 290 300
FVAPITFQLD ELKYAYPDEP IPPGKTAQQH LYDLVWEGAA RHYGADMIPP
310 320 330 340 350
KVQGLINKEL ALIARLEYEP YFLTVYDIVT HAREKGILCQ GRGSAANSVV
360 370 380 390 400
CFCLGITGVN PTQVDLLFER FISAERKEPP DIDVDFEHER REEVMQYVYD
410 420 430 440 450
RYSRDRAAIV ATVISYRSRS AIRDVGKALG LSEDVTAALA NTVWGLSGGG
460 470 480 490 500
IDRQHIRQAG LDPDNPIIQR AVELAITLIG FPRHLSQHVG GFVLTRDRLD
510 520 530 540 550
ETVPIGPAAM DKRSFIEWDK DDIDEVGLMK VDVLSLGMLT CIRKAFDLIH
560 570 580 590 600
QHKPQLYGGE KLTLASLPRK DKAVYDMLCK GDSLGVFQVE SRAQMNMLPR
610 620 630 640 650
LRPQEFYDLV IEVAIVRPGP IQGDMVHPYL RRRSGQEPCT LPSPSPQHGP
660 670 680 690 700
ANELQQILGK TKGVPLFQEQ AMRIAMEAAK FTPEEANQLR RAMATFRKMG
710 720 730 740 750
TIHTMEKKMI DGMVNRGYDR TFAENCFNQI KGFGEYGFPE SHAASFAHLV
760 770 780 790 800
YISAWLKCHH PEVFAAALLN SQPMGFYAPA QIVRDAREHG VTVLPVDVNF
810 820 830 840 850
SQWDNILEET PDVHLALRLG FRQIDGFSKR DTELLIADRQ EPYRTIEDMH
860 870 880 890 900
RRLRLDRRAF TLLADADAFG SLDIDRRAAL WAVRRLPNDE TLPLFRAAAA
910 920 930 940 950
SELAQEPRTK LPEMAASEHV IADYETTRLS LKGHPLQYLR EGLAAEGVST
960 970 980 990 1000
CRAVQEGADG RRMKVAGVVT VRQRPGSAKG VVFLTIEDET GIANIVIWPK
1010 1020 1030 1040 1050
IMKVFRREVM SARLIHIEGR IQRSLEGVVH LVAAKLQDRS AALIEMSGRE
1060 1070
AQRLIAPSQM AHHPRNVRVM PNSRDFH
Length:1,077
Mass (Da):120,966
Last modified:May 10, 2005 - v1
Checksum:i174FFECD599A8B3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73487.1.
RefSeqiYP_220848.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73487; AAX73487; BruAb1_0069.
KEGGibmb:BruAb1_0069.
PATRICi17821659. VBIBruAbo15061_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73487.1.
RefSeqiYP_220848.1. NC_006932.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_0069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX73487; AAX73487; BruAb1_0069.
KEGGibmb:BruAb1_0069.
PATRICi17821659. VBIBruAbo15061_0074.

Phylogenomic databases

eggNOGiCOG0587.
HOGENOMiHOG000021783.
KOiK14162.
OMAiERTVIQW.
OrthoDBiEOG6CZQGR.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-70-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01902. DNApol_error_prone.
InterProiIPR011708. DNA_pol3_alpha.
IPR023073. DNA_pol_error_prone.
IPR029460. DNAPol_HHH.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
IPR003141. Pol/His_phosphatase_N.
IPR016195. Pol/histidinol_Pase-like.
IPR004805. PolC_alpha.
[Graphical view]
PfamiPF07733. DNA_pol3_alpha. 1 hit.
PF14579. HHH_6. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
SMARTiSM00481. POLIIIAc. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 2 hits.
TIGRFAMsiTIGR00594. polc. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiDNAE2_BRUAB
AccessioniPrimary (citable) accession number: Q57FU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 10, 2005
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.