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Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCytochrome c-type biogenesis, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
Alternative name(s):
Heme exporter protein AUniRule annotation
Gene namesi
Name:ccmAUniRule annotation
Ordered Locus Names:BruAb1_0091
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002601881 – 215Cytochrome c biogenesis ATP-binding export protein CcmAAdd BLAST215

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ57FS7
SMRiQ57FS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 215ABC transporterUniRule annotationAdd BLAST213

Sequence similaritiesi

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation

Phylogenomic databases

KOiK02193
OMAiYRPIWIL

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR005895 ABC_transptr_haem_export_CcmA
IPR027417 P-loop_NTPase
PANTHERiPTHR43499 PTHR43499, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01189 ccmA, 1 hit
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51243 CCMA, 1 hit

Sequencei

Sequence statusi: Complete.

Q57FS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLEAENLAG ERGGETIFSH LSFTIGTGQA LVVTGPNGSG KSTLLRIICG
60 70 80 90 100
LLAPEAGEVK LTEGTQIVPV RAACHYLGHQ NAMKPALSVR ENLLFWQKFN
110 120 130 140 150
GGEALDIGAA LEAVDLAGVE HLPFGYLSTG QKRRVSIAKL LVSHRPLWIV
160 170 180 190 200
DEPTAGLDKA SEARFAELMR EHMRQDGMII AATHIPLGLD GAISTTGNAL
210
VRSLDMAAFS VEDIA
Length:215
Mass (Da):22,922
Last modified:May 10, 2005 - v1
Checksum:i81F7EC7B054023F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX73507.1
RefSeqiWP_002965342.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX73507; AAX73507; BruAb1_0091
KEGGibmb:BruAb1_0091

Similar proteinsi

Entry informationi

Entry nameiCCMA_BRUAB
AccessioniPrimary (citable) accession number: Q57FS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health