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Q57FS7

- CCMA_BRUAB

UniProt

Q57FS7 - CCMA_BRUAB

Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene

ccmA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.UniRule annotation

    Catalytic activityi

    ATP + H2O + heme(In) = ADP + phosphate + heme(Out).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi35 – 428ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. heme-transporting ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Cytochrome c-type biogenesis, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-92-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:3.6.3.41UniRule annotation)
    Alternative name(s):
    Heme exporter protein AUniRule annotation
    Gene namesi
    Name:ccmAUniRule annotation
    Ordered Locus Names:BruAb1_0091
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
    2. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 215215Cytochrome c biogenesis ATP-binding export protein CcmAPRO_0000260188Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0091.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57FS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 215213ABC transporterUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4133.
    KOiK02193.
    OMAiRIFHALT.
    OrthoDBiEOG6SNDS1.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01189. ccmA. 1 hit.
    PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57FS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLEAENLAG ERGGETIFSH LSFTIGTGQA LVVTGPNGSG KSTLLRIICG    50
    LLAPEAGEVK LTEGTQIVPV RAACHYLGHQ NAMKPALSVR ENLLFWQKFN 100
    GGEALDIGAA LEAVDLAGVE HLPFGYLSTG QKRRVSIAKL LVSHRPLWIV 150
    DEPTAGLDKA SEARFAELMR EHMRQDGMII AATHIPLGLD GAISTTGNAL 200
    VRSLDMAAFS VEDIA 215
    Length:215
    Mass (Da):22,922
    Last modified:May 10, 2005 - v1
    Checksum:i81F7EC7B054023F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73507.1.
    RefSeqiYP_220868.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73507; AAX73507; BruAb1_0091.
    GeneIDi3339009.
    KEGGibmb:BruAb1_0091.
    PATRICi17821713. VBIBruAbo15061_0100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73507.1 .
    RefSeqi YP_220868.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57FS7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0091.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73507 ; AAX73507 ; BruAb1_0091 .
    GeneIDi 3339009.
    KEGGi bmb:BruAb1_0091.
    PATRICi 17821713. VBIBruAbo15061_0100.

    Phylogenomic databases

    eggNOGi COG4133.
    KOi K02193.
    OMAi RIFHALT.
    OrthoDBi EOG6SNDS1.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-92-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR005895. ABC_transptr_haem_export_CcmA.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01189. ccmA. 1 hit.
    PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51243. CCMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiCCMA_BRUAB
    AccessioniPrimary (citable) accession number: Q57FS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3