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Q57FS7 (CCMA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA

EC=3.6.3.41
Alternative name(s):
Heme exporter protein A
Gene names
Name:ccmA
Ordered Locus Names:BruAb1_0091
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Subunit structure

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processCytochrome c-type biogenesis
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcytochrome complex assembly

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

heme-transporting ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Cytochrome c biogenesis ATP-binding export protein CcmA
PRO_0000260188

Regions

Domain3 – 215213ABC transporter
Nucleotide binding35 – 428ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q57FS7 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 81F7EC7B054023F1

FASTA21522,922
        10         20         30         40         50         60 
MRLEAENLAG ERGGETIFSH LSFTIGTGQA LVVTGPNGSG KSTLLRIICG LLAPEAGEVK 

        70         80         90        100        110        120 
LTEGTQIVPV RAACHYLGHQ NAMKPALSVR ENLLFWQKFN GGEALDIGAA LEAVDLAGVE 

       130        140        150        160        170        180 
HLPFGYLSTG QKRRVSIAKL LVSHRPLWIV DEPTAGLDKA SEARFAELMR EHMRQDGMII 

       190        200        210 
AATHIPLGLD GAISTTGNAL VRSLDMAAFS VEDIA 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX73507.1.
RefSeqYP_220868.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57FS7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_0091.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX73507; AAX73507; BruAb1_0091.
GeneID3339009.
KEGGbmb:BruAb1_0091.
PATRIC17821713. VBIBruAbo15061_0100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4133.
KOK02193.
OMAFYQSIHN.
OrthoDBEOG6SNDS1.
ProtClustDBPRK13539.

Enzyme and pathway databases

BioCycBABO262698:GJC2-92-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01189. ccmA. 1 hit.
PROSITEPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCCMA_BRUAB
AccessionPrimary (citable) accession number: Q57FS7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names