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Q57FS7

- CCMA_BRUAB

UniProt

Q57FS7 - CCMA_BRUAB

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Protein

Cytochrome c biogenesis ATP-binding export protein CcmA

Gene
ccmA, BruAb1_0091
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity.

Catalytic activityi

ATP + H2O + heme(In) = ADP + phosphate + heme(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi35 – 428ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. heme-transporting ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytochrome c-type biogenesis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-92-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA (EC:3.6.3.41)
Alternative name(s):
Heme exporter protein A
Gene namesi
Name:ccmA
Ordered Locus Names:BruAb1_0091
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
  2. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Cytochrome c biogenesis ATP-binding export protein CcmAPRO_0000260188Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.

Protein-protein interaction databases

STRINGi262698.BruAb1_0091.

Structurei

3D structure databases

ProteinModelPortaliQ57FS7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 215213ABC transporterAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4133.
KOiK02193.
OMAiRIFHALT.
OrthoDBiEOG6SNDS1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01189. ccmA. 1 hit.
PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57FS7-1 [UniParc]FASTAAdd to Basket

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MRLEAENLAG ERGGETIFSH LSFTIGTGQA LVVTGPNGSG KSTLLRIICG    50
LLAPEAGEVK LTEGTQIVPV RAACHYLGHQ NAMKPALSVR ENLLFWQKFN 100
GGEALDIGAA LEAVDLAGVE HLPFGYLSTG QKRRVSIAKL LVSHRPLWIV 150
DEPTAGLDKA SEARFAELMR EHMRQDGMII AATHIPLGLD GAISTTGNAL 200
VRSLDMAAFS VEDIA 215
Length:215
Mass (Da):22,922
Last modified:May 10, 2005 - v1
Checksum:i81F7EC7B054023F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73507.1.
RefSeqiYP_220868.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73507; AAX73507; BruAb1_0091.
GeneIDi3339009.
KEGGibmb:BruAb1_0091.
PATRICi17821713. VBIBruAbo15061_0100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73507.1 .
RefSeqi YP_220868.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57FS7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX73507 ; AAX73507 ; BruAb1_0091 .
GeneIDi 3339009.
KEGGi bmb:BruAb1_0091.
PATRICi 17821713. VBIBruAbo15061_0100.

Phylogenomic databases

eggNOGi COG4133.
KOi K02193.
OMAi RIFHALT.
OrthoDBi EOG6SNDS1.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-92-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR005895. ABC_transptr_haem_export_CcmA.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01189. ccmA. 1 hit.
PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51243. CCMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiCCMA_BRUAB
AccessioniPrimary (citable) accession number: Q57FS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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