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Q57F56

- OTC_BRUAB

UniProt

Q57F56 - OTC_BRUAB

Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

    Catalytic activityi

    Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei32 – 321Important for structural integrityUniRule annotation
    Binding sitei84 – 841Carbamoyl phosphateUniRule annotation
    Binding sitei108 – 1081Carbamoyl phosphateUniRule annotation
    Sitei148 – 1481Important for structural integrityUniRule annotation
    Binding sitei166 – 1661OrnithineBy similarity
    Binding sitei226 – 2261OrnithineBy similarity
    Binding sitei275 – 2751Carbamoyl phosphateUniRule annotation
    Binding sitei293 – 2931Carbamoyl phosphateUniRule annotation

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. ornithine carbamoyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-334-MONOMER.
    UniPathwayiUPA00068; UER00112.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine carbamoyltransferaseUniRule annotation (EC:2.1.3.3UniRule annotation)
    Short name:
    OTCaseUniRule annotation
    Gene namesi
    Name:argFUniRule annotation
    Ordered Locus Names:BruAb1_0328
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Ornithine carbamoyltransferasePRO_1000065077Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57F56.
    SMRiQ57F56. Positions 8-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 615Carbamoyl phosphate bindingUniRule annotation
    Regioni135 – 1384Carbamoyl phosphate bindingUniRule annotation
    Regioni230 – 2312Ornithine bindingUniRule annotation
    Regioni264 – 2674Carbamoyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the ATCase/OTCase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0078.
    HOGENOMiHOG000022686.
    OMAiDMMARAN.
    OrthoDBiEOG690MGV.

    Family and domain databases

    Gene3Di3.40.50.1370. 2 hits.
    HAMAPiMF_01109. OTCase.
    InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view]
    PfamiPF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view]
    PRINTSiPR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMiSSF53671. SSF53671. 1 hit.
    TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
    PROSITEiPS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57F56-1 [UniParc]FASTAAdd to Basket

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    MANDNGIKHF IDLSTVPATE LRAILEDAKA RKARLKAGEV ERPYAGKVLA    50
    MIFEKLSTRT RVSFDVGMRQ LGGETIMLTG SEMQLGRSET IADTAKVLSR 100
    YVDAIMIRTT AHERMLELAE YATVPVINAL TDDTHPCQIM ADVLTYEEHR 150
    GPIKGKTFAW MGDGNNVLHS LVEAAARFDF NVNIATPKGS EPKSQYIDWA 200
    RANGAGIMST TDPEKAASGA DCIVTDTWVS MGQEDHARGH NVFIPYQVNA 250
    NLMAKADPKA LFMHCLPAHR GEEVTDEVID GPQSVVFDEA ENRLHAQKAI 300
    LAWCLQDRGL GA 312
    Length:312
    Mass (Da):34,239
    Last modified:May 10, 2005 - v1
    Checksum:i60DBB4EC456B939C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73728.1.
    RefSeqiYP_221089.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73728; AAX73728; BruAb1_0328.
    GeneIDi3339044.
    KEGGibmb:BruAb1_0328.
    PATRICi17822236. VBIBruAbo15061_0355.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73728.1 .
    RefSeqi YP_221089.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57F56.
    SMRi Q57F56. Positions 8-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73728 ; AAX73728 ; BruAb1_0328 .
    GeneIDi 3339044.
    KEGGi bmb:BruAb1_0328.
    PATRICi 17822236. VBIBruAbo15061_0355.

    Phylogenomic databases

    eggNOGi COG0078.
    HOGENOMi HOG000022686.
    OMAi DMMARAN.
    OrthoDBi EOG690MGV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00112 .
    BioCyci BABO262698:GJC2-334-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1370. 2 hits.
    HAMAPi MF_01109. OTCase.
    InterProi IPR006132. Asp/Orn_carbamoyltranf_P-bd.
    IPR006130. Asp/Orn_carbamoylTrfase.
    IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
    IPR002292. Orn/put_carbamltrans.
    IPR024904. Orn_carbamltrans.
    [Graphical view ]
    Pfami PF00185. OTCace. 1 hit.
    PF02729. OTCace_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00100. AOTCASE.
    PR00102. OTCASE.
    SUPFAMi SSF53671. SSF53671. 1 hit.
    TIGRFAMsi TIGR00658. orni_carb_tr. 1 hit.
    PROSITEi PS00097. CARBAMOYLTRANSFERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiOTC_BRUAB
    AccessioniPrimary (citable) accession number: Q57F56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3