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Q57F56 (OTC_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:argF
Ordered Locus Names:BruAb1_0328
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline By similarity. HAMAP-Rule MF_01109

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP-Rule MF_01109

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP-Rule MF_01109

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Ornithine carbamoyltransferase HAMAP-Rule MF_01109
PRO_1000065077

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region135 – 1384Carbamoyl phosphate binding By similarity
Region230 – 2312Ornithine binding By similarity
Region264 – 2674Carbamoyl phosphate binding By similarity

Sites

Binding site841Carbamoyl phosphate By similarity
Binding site1081Carbamoyl phosphate By similarity
Binding site1661Ornithine By similarity
Binding site2261Ornithine By similarity
Binding site2751Carbamoyl phosphate By similarity
Binding site2931Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57F56 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 60DBB4EC456B939C

FASTA31234,239
        10         20         30         40         50         60 
MANDNGIKHF IDLSTVPATE LRAILEDAKA RKARLKAGEV ERPYAGKVLA MIFEKLSTRT 

        70         80         90        100        110        120 
RVSFDVGMRQ LGGETIMLTG SEMQLGRSET IADTAKVLSR YVDAIMIRTT AHERMLELAE 

       130        140        150        160        170        180 
YATVPVINAL TDDTHPCQIM ADVLTYEEHR GPIKGKTFAW MGDGNNVLHS LVEAAARFDF 

       190        200        210        220        230        240 
NVNIATPKGS EPKSQYIDWA RANGAGIMST TDPEKAASGA DCIVTDTWVS MGQEDHARGH 

       250        260        270        280        290        300 
NVFIPYQVNA NLMAKADPKA LFMHCLPAHR GEEVTDEVID GPQSVVFDEA ENRLHAQKAI 

       310 
LAWCLQDRGL GA

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References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX73728.1.
RefSeqYP_221089.1. NC_006932.1.

3D structure databases

HSSPHSSP built from PDB template 1PVV based on UniProtKB Q51742.
ProteinModelPortalQ57F56.
SMRQ57F56. Positions 8-307.
ModBaseSearch...

Protein-protein interaction databases

STRING262698.BruAb1_0328.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX73728; AAX73728; BruAb1_0328.
GeneID3339044.
KEGGbmb:BruAb1_0328.
PATRIC17822236. VBIBruAbo15061_0355.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0078.
HOGENOMHOG000022686.
OMAKHLLSIK.
ProtClustDBPRK00779.

Enzyme and pathway databases

BioCycBABO262698:GJC2-334-MONOMER.
UniPathwayUPA00068; UER00112.

Family and domain databases

HAMAPMF_01109. OTCase.
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_BRUAB
AccessionPrimary (citable) accession number: Q57F56
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 10, 2005
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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