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Q57F47

- PYRD_BRUAB

UniProt

Q57F47 - PYRD_BRUAB

Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotation

    Catalytic activityi

    (S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

    Cofactori

    Binds 1 FMN per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei85 – 851FMN; via amide nitrogenUniRule annotation
    Binding sitei139 – 1391FMNUniRule annotation
    Binding sitei170 – 1701FMNUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Active sitei173 – 1731NucleophileUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Binding sitei215 – 2151FMNUniRule annotation
    Binding sitei243 – 2431FMN; via carbonyl oxygenUniRule annotation
    Binding sitei266 – 2661FMN; via amide nitrogenUniRule annotation
    Binding sitei295 – 2951FMN; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 655FMNUniRule annotation
    Nucleotide bindingi316 – 3172FMNUniRule annotation

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-343-MONOMER.
    UniPathwayiUPA00070; UER00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
    Alternative name(s):
    DHOdehaseUniRule annotation
    Short name:
    DHODUniRule annotation
    Short name:
    DHODaseUniRule annotation
    Dihydroorotate oxidaseUniRule annotation
    Gene namesi
    Name:pyrDUniRule annotation
    Ordered Locus Names:BruAb1_0337
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Dihydroorotate dehydrogenase (quinone)PRO_0000244528Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0337.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57F47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 1145Substrate bindingUniRule annotation
    Regioni244 – 2452Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0167.
    HOGENOMiHOG000225103.
    KOiK00254.
    OMAiDARDEMQ.
    OrthoDBiEOG65BDN8.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00225. DHO_dh_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
    PROSITEiPS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57F47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGLFETLGR RALFTFDAEQ AHGLSITGLK TGIVTCRTPE DPALSVKVAG    50
    LKFPNPLGMA AGYDKNAEVP DALLKLGFGF AEVGTLTPRP QSGNPRPRIF 100
    RLVDDKAVIN RLGFNNEGHE AAFKRLSRRA GKSGIVGVNI GANKDAEDRI 150
    ADYVAGIRRF YLLARYFTVN ISSPNTPGLR NLQAREALHE LLSRVLEARD 200
    EEGNMCTLKR PVFLKIAPDL TDEELDDIAA EADAQKLDGI IVSNTTLSRS 250
    GLKNPENSNE TGGLSGAPLF ERSTVVLARM RERVGPDMPL IGVGGIDSAE 300
    TALAKIKAGA DLVQLYTGLI YRGPGLPGEI LRGLSTAIKH EGVSSIAELR 350
    DRDTKEWAAR KLIS 364
    Length:364
    Mass (Da):39,257
    Last modified:May 10, 2005 - v1
    Checksum:i909F4EAB00AF230E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73737.1.
    RefSeqiYP_221098.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73737; AAX73737; BruAb1_0337.
    GeneIDi3339285.
    KEGGibmb:BruAb1_0337.
    PATRICi17822254. VBIBruAbo15061_0364.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73737.1 .
    RefSeqi YP_221098.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57F47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73737 ; AAX73737 ; BruAb1_0337 .
    GeneIDi 3339285.
    KEGGi bmb:BruAb1_0337.
    PATRICi 17822254. VBIBruAbo15061_0364.

    Phylogenomic databases

    eggNOGi COG0167.
    HOGENOMi HOG000225103.
    KOi K00254.
    OMAi DARDEMQ.
    OrthoDBi EOG65BDN8.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00946 .
    BioCyci BABO262698:GJC2-343-MONOMER.

    Miscellaneous databases

    PROi Q57F47.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00225. DHO_dh_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
    PROSITEi PS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiPYRD_BRUAB
    AccessioniPrimary (citable) accession number: Q57F47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3