Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q57F40 (MSCL_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Large-conductance mechanosensitive channel
Gene names
Name:mscL
Ordered Locus Names:BruAb1_0344
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP-Rule MF_00115

Subunit structure

Homopentamer By similarity. HAMAP-Rule MF_00115

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00115.

Sequence similarities

Belongs to the MscL family.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Large-conductance mechanosensitive channel HAMAP-Rule MF_00115
PRO_0000192434

Regions

Transmembrane15 – 3521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane80 – 10021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q57F40 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 64ADC7B8F6239A96

FASTA13814,899
        10         20         30         40         50         60 
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 

        70         80         90        100        110        120 
GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 

       130 
EEVLLTEIRD ILAKQQKA 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX73744.1.
RefSeqYP_221105.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57F40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_0344.

Proteomic databases

PRIDEQ57F40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX73744; AAX73744; BruAb1_0344.
GeneID3339395.
KEGGbmb:BruAb1_0344.
PATRIC17822268. VBIBruAbo15061_0371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1970.
HOGENOMHOG000226782.
KOK03282.
OMASDIIMPP.
OrthoDBEOG696C3G.
ProtClustDBPRK13952.

Enzyme and pathway databases

BioCycBABO262698:GJC2-350-MONOMER.

Family and domain databases

HAMAPMF_00115. MscL.
InterProIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamPF01741. MscL. 1 hit.
[Graphical view]
PRINTSPR01264. MECHCHANNEL.
SUPFAMSSF81330. SSF81330. 1 hit.
TIGRFAMsTIGR00220. mscL. 1 hit.
PROSITEPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMSCL_BRUAB
AccessionPrimary (citable) accession number: Q57F40
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names