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Q57F40

- MSCL_BRUAB

UniProt

Q57F40 - MSCL_BRUAB

Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

    GO - Molecular functioni

    1. ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-350-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large-conductance mechanosensitive channelUniRule annotation
    Gene namesi
    Name:mscLUniRule annotation
    Ordered Locus Names:BruAb1_0344
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000192434Add
    BLAST

    Proteomic databases

    PRIDEiQ57F40.

    Interactioni

    Subunit structurei

    Homopentamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0344.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57F40.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalUniRule annotationAdd
    BLAST
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MscL family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1970.
    HOGENOMiHOG000226782.
    KOiK03282.
    OMAiFINACIN.
    OrthoDBiEOG696C3G.

    Family and domain databases

    HAMAPiMF_00115. MscL.
    InterProiIPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view]
    PfamiPF01741. MscL. 1 hit.
    [Graphical view]
    PRINTSiPR01264. MECHCHANNEL.
    SUPFAMiSSF81330. SSF81330. 1 hit.
    TIGRFAMsiTIGR00220. mscL. 1 hit.
    PROSITEiPS01327. MSCL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57F40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI    50
    DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV 100
    KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA 138
    Length:138
    Mass (Da):14,899
    Last modified:May 10, 2005 - v1
    Checksum:i64ADC7B8F6239A96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73744.1.
    RefSeqiYP_221105.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX73744; AAX73744; BruAb1_0344.
    GeneIDi3339395.
    KEGGibmb:BruAb1_0344.
    PATRICi17822268. VBIBruAbo15061_0371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX73744.1 .
    RefSeqi YP_221105.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57F40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0344.

    Proteomic databases

    PRIDEi Q57F40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX73744 ; AAX73744 ; BruAb1_0344 .
    GeneIDi 3339395.
    KEGGi bmb:BruAb1_0344.
    PATRICi 17822268. VBIBruAbo15061_0371.

    Phylogenomic databases

    eggNOGi COG1970.
    HOGENOMi HOG000226782.
    KOi K03282.
    OMAi FINACIN.
    OrthoDBi EOG696C3G.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-350-MONOMER.

    Family and domain databases

    HAMAPi MF_00115. MscL.
    InterProi IPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view ]
    Pfami PF01741. MscL. 1 hit.
    [Graphical view ]
    PRINTSi PR01264. MECHCHANNEL.
    SUPFAMi SSF81330. SSF81330. 1 hit.
    TIGRFAMsi TIGR00220. mscL. 1 hit.
    PROSITEi PS01327. MSCL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiMSCL_BRUAB
    AccessioniPrimary (citable) accession number: Q57F40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3