Reviewed,
UniProtKB/Swiss-Prot Q57F40 (MSCL_BRUAB)
Last modified
November 24, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Large-conductance mechanosensitive channel | ||||
| Gene names |
| ||||
| Organism | Brucella abortus [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 235 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 138 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. |
| Subunit structure | Homopentamer By similarity. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the mscL family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Ionic channel |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ion transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 138 | 138 | Large-conductance mechanosensitive channel HAMAP MF_00115 | PRO_0000192434 | |||||
Regions | |||||||||
| Transmembrane | 15 – 35 | 21 | Potential | ||||||
| Transmembrane | 38 – 58 | 21 | Potential | ||||||
| Transmembrane | 80 – 100 | 21 | Potential | ||||||
Sequences
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References
| [1] | "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1. |
Cross-references
Sequence databases | |
|---|---|
| AE017223 Genomic DNA. Translation: AAX73744.1. | |
| RefSeq | YP_221105.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3339395. |
| GenomeReviews | Gene locus BruAb1_0344 in contig AE017223_GR. |
| KEGG | bmb:BruAb1_0344. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q57F40. |
| OMA | MIKEFKE |
Enzyme and pathway databases | |
| BioCyc | BABO262698:BRUAB1_0344-MON. |
Family and domain databases | |
| HAMAP | MF_00115. [Tree] |
| InterPro | IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view] |
| Pfam | PF01741. MscL. 1 hit. [Graphical view] |
| PRINTS | PR01264. MECHCHANNEL. |
| TIGRFAMs | TIGR00220. mscL. 1 hit. |
| PROSITE | PS01327. MSCL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MSCL_BRUAB | ||||||||
| Accession | Primary (citable) accession number: Q57F40 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella abortus strain 9-941 Brucella abortus (strain 9-941): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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