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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBABO262698:GJC2-350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:BruAb1_0344
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000192434Add
BLAST

Proteomic databases

PRIDEiQ57F40.

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0344.

Structurei

3D structure databases

ProteinModelPortaliQ57F40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiSDIIMPP.
OrthoDBiEOG696C3G.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57F40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI
60 70 80 90 100
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV
110 120 130
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA
Length:138
Mass (Da):14,899
Last modified:May 10, 2005 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73744.1.
RefSeqiYP_221105.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73744; AAX73744; BruAb1_0344.
GeneIDi3339395.
KEGGibmb:BruAb1_0344.
PATRICi17822268. VBIBruAbo15061_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73744.1.
RefSeqiYP_221105.1. NC_006932.1.

3D structure databases

ProteinModelPortaliQ57F40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_0344.

Proteomic databases

PRIDEiQ57F40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX73744; AAX73744; BruAb1_0344.
GeneIDi3339395.
KEGGibmb:BruAb1_0344.
PATRICi17822268. VBIBruAbo15061_0371.

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiSDIIMPP.
OrthoDBiEOG696C3G.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-350-MONOMER.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiMSCL_BRUAB
AccessioniPrimary (citable) accession number: Q57F40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.