Reviewed, UniProtKB/Swiss-Prot Q57F40 (MSCL_BRUAB)

Names and origin

Protein names

Recommended name:
    Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	BruAb1_0344

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity.
Subunit structure	Homopentamer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the mscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000192434
Regions
	Transmembrane	15 – 35	21	Potential
	Transmembrane	38 – 58	21	Potential
	Transmembrane	80 – 100	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57F40-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 64ADC7B8F6239A96	FASTA	138	14,899
	10 20 30 40 50 60 MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 70 80 90 100 110 120 GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 130 EEVLLTEIRD ILAKQQKA

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017223 Genomic DNA. Translation: AAX73744.1.
RefSeq	YP_221105.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3339395.
GenomeReviews	Gene locus BruAb1_0344 in contig AE017223_GR.
KEGG	bmb:BruAb1_0344.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q57F40.
OMA	MIKEFKE
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0344-MON.
Family and domain databases
HAMAP	MF_00115. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
TIGRFAMs	TIGR00220. mscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_BRUAB

Accession

Primary (citable) accession number: Q57F40

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	May 10, 2005
Last modified:	November 24, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)