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Q57F40

- MSCL_BRUAB

UniProt

Q57F40 - MSCL_BRUAB

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Protein

Large-conductance mechanosensitive channel

Gene
mscL, BruAb1_0344
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity.UniRule annotation

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciBABO262698:GJC2-350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channel
Gene namesi
Name:mscL
Ordered Locus Names:BruAb1_0344
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Large-conductance mechanosensitive channelUniRule annotationPRO_0000192434Add
BLAST

Proteomic databases

PRIDEiQ57F40.

Interactioni

Subunit structurei

Homopentamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0344.

Structurei

3D structure databases

ProteinModelPortaliQ57F40.

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiFINACIN.
OrthoDBiEOG696C3G.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57F40-1 [UniParc]FASTAAdd to Basket

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MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI    50
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV 100
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA 138
Length:138
Mass (Da):14,899
Last modified:May 10, 2005 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73744.1.
RefSeqiYP_221105.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73744; AAX73744; BruAb1_0344.
GeneIDi3339395.
KEGGibmb:BruAb1_0344.
PATRICi17822268. VBIBruAbo15061_0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73744.1 .
RefSeqi YP_221105.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57F40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0344.

Proteomic databases

PRIDEi Q57F40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX73744 ; AAX73744 ; BruAb1_0344 .
GeneIDi 3339395.
KEGGi bmb:BruAb1_0344.
PATRICi 17822268. VBIBruAbo15061_0371.

Phylogenomic databases

eggNOGi COG1970.
HOGENOMi HOG000226782.
KOi K03282.
OMAi FINACIN.
OrthoDBi EOG696C3G.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-350-MONOMER.

Family and domain databases

HAMAPi MF_00115. MscL.
InterProi IPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view ]
Pfami PF01741. MscL. 1 hit.
[Graphical view ]
PRINTSi PR01264. MECHCHANNEL.
SUPFAMi SSF81330. SSF81330. 1 hit.
TIGRFAMsi TIGR00220. mscL. 1 hit.
PROSITEi PS01327. MSCL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiMSCL_BRUAB
AccessioniPrimary (citable) accession number: Q57F40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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