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Q57EY6 (DER_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTPase Der
Alternative name(s):
GTP-binding protein EngA
Gene names
Name:der
Synonyms:engA
Ordered Locus Names:BruAb1_0401
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

GTPase that plays an essential role in the late steps of ribosome biogenesis By similarity. HAMAP MF_00195

Subunit structure

Associates with the 50S ribosomal subunit By similarity.

Sequence similarities

Belongs to the Era/MnmE GTP-binding protein family. Der subfamily.

Contains 2 G (guanine nucleotide-binding) domains.

Contains 1 KH-like domain.

Ontologies

Keywords
   Biological processRibosome biogenesis
   DomainRepeat
   LigandGTP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processribosome biogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483GTPase Der HAMAP MF_00195
PRO_1000011576

Regions

Domain14 – 120107G 1
Domain223 – 331109G 2
Domain387 – 47286KH-like
Nucleotide binding9 – 168GTP 1 Potential
Nucleotide binding56 – 605GTP 1 Potential
Nucleotide binding119 – 1224GTP 1 Potential
Nucleotide binding218 – 2258GTP 2 Potential
Nucleotide binding265 – 2695GTP 2 Potential
Nucleotide binding330 – 3334GTP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
Q57EY6 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 5062657AF4EF8061

FASTA48353,297
        10         20         30         40         50         60 
MGFTLAIVGR PNVGKSTLFN RLVGRKLALV DDLPGVTRDR RIHDAKLYDL KFQVIDTAGL 

        70         80         90        100        110        120 
EEAANDSLEA RMRAQTEAAI SEADAVLFVI DAKAGITPAD STFAEAVRRS GKPVVLVANK 

       130        140        150        160        170        180 
AEARGSEAGM YDAFQLGLGE PCPISAEHGQ GMPDLRDAIV ELLGEERVFA EERQEEAADE 

       190        200        210        220        230        240 
VFTPAAVGAL VGDDIEDPDA EEIPAYDATK PLRIAIVGRP NAGKSTLINT MLGEDRLLTG 

       250        260        270        280        290        300 
PEAGITRDSI SADWEWHGRK INLFDTAGMR RKARVQEKLE KLSVADSLRA IRFAEVVIIV 

       310        320        330        340        350        360 
LDATIPFEKQ DLQIADLIIR EGRAPVIAFN KWDLIEDRQM VLADLYEKTA RLLPQVRGLR 

       370        380        390        400        410        420 
AVPISGERGQ GIDKLMENVV KTHEIWNRRI STGRLNRWLE GVIAHQPPPA VSGRRLKVKY 

       430        440        450        460        470        480 
MTQVKTRPPG FVVSCSRPDA MPQSYVRYLI NGLRETFDMP GVPIRLSLRT SDNPFAGRAK 


KKK

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX73798.1.
RefSeqYP_221159.1. NC_006932.1.

3D structure databases

HSSPHSSP built from PDB template 1MKY based on UniProtKB Q9X1F8.
ProteinModelPortalQ57EY6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3339863.
GenomeReviewsGene locus BruAb1_0401 in contig AE017223_GR.
KEGGbmb:BruAb1_0401.
PATRIC17822388. VBIBruAbo15061_0431.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG592135.
OMALAVNKCE.
PhylomeDBQ57EY6.
ProtClustDBPRK00093.

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_0401-MONOMER.

Family and domain databases

HAMAPMF_00195. GTPase_Der.
[Tree]
InterProIPR016484. GTP-bd_EngA.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR005225. Small_GTP-bd_dom.
[Graphical view]
Gene3DG3DSA:3.30.300.20. KH_prok. 1 hit.
KOK03977.
PANTHERPTHR11649:SF5. PTHR11649:SF5. 1 hit.
PfamPF01926. MMR_HSR1. 2 hits.
[Graphical view]
PIRSFPIRSF006485. GTP-binding_EngA. 1 hit.
PRINTSPR00326. GTP1OBG.
TIGRFAMsTIGR03594. GTPase_EngA. 1 hit.
TIGR00231. Small_GTP. 2 hits.
ProtoNetSearch...

Entry information

Entry nameDER_BRUAB
AccessionPrimary (citable) accession number: Q57EY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

SIMILARITY comments

Index of protein domains and families

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