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Protein

ATP synthase subunit a

Gene

atpB

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.UniRule annotation

GO - Molecular functioni

  1. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciBABO262698:GJC2-413-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit aUniRule annotation
Alternative name(s):
ATP synthase F0 sector subunit aUniRule annotation
F-ATPase subunit 6UniRule annotation
Gene namesi
Name:atpBUniRule annotation
Ordered Locus Names:BruAb1_0407
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei185 – 20521HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(0), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249ATP synthase subunit aPRO_0000362252Add
BLAST

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0407.

Structurei

3D structure databases

ProteinModelPortaliQ57EY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0356.
HOGENOMiHOG000253874.
KOiK02108.
OMAiQVFLTSW.
OrthoDBiEOG6K4054.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact.
InterProiIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57EY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDPIHQFQ VSRWIPIDVG GVDLSFTNVS AFMVATVVLA SGFLYLTSSG
60 70 80 90 100
RGLIPTRLQS VSEMAYEFVA TSLRDSAGSK GMKFFPFVFS LFMFVLVANF
110 120 130 140 150
IGLFPYFYTV TSQIIVTFAL SLLVIGTVIF YGFFKHGFGF LKLFVPSGVP
160 170 180 190 200
GIIVPLVVLI EIISFLSRPI SLSVRLFANM LAGHITLKVF AGFVVSLSSL
210 220 230 240
GALGIGGAVL PLLMTVAITA LEFLVAFLQA YVFTVLTCMY INDAVHPGH
Length:249
Mass (Da):26,979
Last modified:May 10, 2005 - v1
Checksum:i0322177F778BAE6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73804.1.
RefSeqiYP_221165.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73804; AAX73804; BruAb1_0407.
KEGGibmb:BruAb1_0407.
PATRICi17822396. VBIBruAbo15061_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73804.1.
RefSeqiYP_221165.1. NC_006932.1.

3D structure databases

ProteinModelPortaliQ57EY0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_0407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX73804; AAX73804; BruAb1_0407.
KEGGibmb:BruAb1_0407.
PATRICi17822396. VBIBruAbo15061_0435.

Phylogenomic databases

eggNOGiCOG0356.
HOGENOMiHOG000253874.
KOiK02108.
OMAiQVFLTSW.
OrthoDBiEOG6K4054.

Enzyme and pathway databases

BioCyciBABO262698:GJC2-413-MONOMER.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact.
InterProiIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiATP6_BRUAB
AccessioniPrimary (citable) accession number: Q57EY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 10, 2005
Last modified: April 1, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.