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Q57EX6

- RNH2_BRUAB

UniProt

Q57EX6 - RNH2_BRUAB

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Protein
Ribonuclease HII
Gene
rnhB, BruAb1_0411
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381Divalent metal cation By similarity
Metal bindingi39 – 391Divalent metal cation By similarity
Metal bindingi130 – 1301Divalent metal cation By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HII (EC:3.1.26.4)
Short name:
RNase HII
Gene namesi
Name:rnhB
Ordered Locus Names:BruAb1_0411
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Ribonuclease HIIUniRule annotation
PRO_0000111550Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_0411.

Structurei

3D structure databases

ProteinModelPortaliQ57EX6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.

Phylogenomic databases

eggNOGiCOG0164.
HOGENOMiHOG000100288.
KOiK03470.
OMAiIMVDLAQ.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q57EX6-1 [UniParc]FASTAAdd to Basket

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MKRSASDSPL LFDLPLAPDF SQEQQLMKRG LKHIAGIDEA GRGPLAGPVV    50
AAAVVLDQND LPEGLDDSKR LTAARREALY EIILTKAITV SVASLSARSI 100
DASDIRKAAL EAMRRAVIGL TLKPCHALVD GRDVPPGLPC PGSALVKGDQ 150
RSVSIAAASI VAKVTRDRMM IRAGAAHPPY GLEIHAGYAT QKHRAAIESE 200
GPVPGLHRYT FAPIKGCFDC 220
Length:220
Mass (Da):23,332
Last modified:May 10, 2005 - v1
Checksum:i87E3AB1CD4844E8E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73808.1.
RefSeqiYP_221169.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73808; AAX73808; BruAb1_0411.
GeneIDi3339134.
KEGGibmb:BruAb1_0411.
PATRICi17822404. VBIBruAbo15061_0439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX73808.1 .
RefSeqi YP_221169.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57EX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0411.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX73808 ; AAX73808 ; BruAb1_0411 .
GeneIDi 3339134.
KEGGi bmb:BruAb1_0411.
PATRICi 17822404. VBIBruAbo15061_0439.

Phylogenomic databases

eggNOGi COG0164.
HOGENOMi HOG000100288.
KOi K03470.
OMAi IMVDLAQ.
OrthoDBi EOG6BKJC8.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-417-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00052_B. RNase_HII_B.
InterProi IPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10954. PTHR10954. 1 hit.
Pfami PF01351. RNase_HII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiRNH2_BRUAB
AccessioniPrimary (citable) accession number: Q57EX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi