Reviewed, UniProtKB/Swiss-Prot Q57ET8 (AROC_BRUAB)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BruAb1_0450

Organism

Brucella abortus [Complete proteome] [HAMAP]

Taxonomic identifier

235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Chorismate synthase HAMAP MF_00300		PRO_0000256276

Sequences

	Sequence		Length	Mass (Da)
	Q57ET8-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 95F83B4FD5230C0E	FASTA	364	38,988
	10 20 30 40 50 60 MSHNSFGHLF RVTTWGESHG LALGCVVDGC PPGITFTEAE IQSFLDKRKP GQSKYTTQRR 70 80 90 100 110 120 EPDQVRVLSG VLLGEDGVTM TTTGTPISMM IENTDQRSKD YGEIARQYRP GHADYAYDVK 130 140 150 160 170 180 YGIRDYRGGG RSSARETAAR VAAGAIARKV VPGLEVRGAL VSIGAHDIDR SRWNWAEVDN 190 200 210 220 230 240 NPFFTPDAGS VEVFADYLDG IRKNGSSVGA IIEIVAEGVP AGIGAPIYGK LDQDIASYLM 250 260 270 280 290 300 SINAVKGVEI GNGFEAARLT GEENADEMRM GNDGKPIFLS NHAGGVLGGI ATGAPVVARF 310 320 330 340 350 360 AVKPTSSILT PRRSIDKDGN EVDVMTRGRH DPCVGIRAVP IGEAMVACAI ADHYLRHRGQ TGRV

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941 / Biovar 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX73846.1.
RefSeq	YP_221207.1.
3D structure databases
HSSP	HSSP built from PDB template 1R53 based on UniProtKB P28777.
SMR	Q57ET8. Positions 4-360.
ModBase	Search...
Genome annotation databases
GeneID	3340084.
GenomeReviews	Gene locus BruAb1_0450 in contig AE017223_GR.
KEGG	bmb:BruAb1_0450.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q57ET8.
Enzyme and pathway databases
BioCyc	BABO262698:BRUAB1_0450-MONOMER.
BRENDA	4.2.3.5. 575.
Family and domain databases
HAMAP	MF_00300_B. Chorismate_synth_B. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BRUAB

Accession

Primary (citable) accession number: Q57ET8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 10, 2005
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)