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Q57ET8 (AROC_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:BruAb1_0450
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Chorismate synthase HAMAP MF_00300
PRO_0000256276

Sequences

Sequence LengthMass (Da)Tools
Q57ET8 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 95F83B4FD5230C0E

FASTA36438,988
        10         20         30         40         50         60 
MSHNSFGHLF RVTTWGESHG LALGCVVDGC PPGITFTEAE IQSFLDKRKP GQSKYTTQRR 

        70         80         90        100        110        120 
EPDQVRVLSG VLLGEDGVTM TTTGTPISMM IENTDQRSKD YGEIARQYRP GHADYAYDVK 

       130        140        150        160        170        180 
YGIRDYRGGG RSSARETAAR VAAGAIARKV VPGLEVRGAL VSIGAHDIDR SRWNWAEVDN 

       190        200        210        220        230        240 
NPFFTPDAGS VEVFADYLDG IRKNGSSVGA IIEIVAEGVP AGIGAPIYGK LDQDIASYLM 

       250        260        270        280        290        300 
SINAVKGVEI GNGFEAARLT GEENADEMRM GNDGKPIFLS NHAGGVLGGI ATGAPVVARF 

       310        320        330        340        350        360 
AVKPTSSILT PRRSIDKDGN EVDVMTRGRH DPCVGIRAVP IGEAMVACAI ADHYLRHRGQ 


TGRV

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed: 15805518] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017223 Genomic DNA. Translation: AAX73846.1.
RefSeqYP_221207.1. NC_006932.1.

3D structure databases

HSSPHSSP built from PDB template 1R53 based on UniProtKB P28777.
ProteinModelPortalQ57ET8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3340084.
GenomeReviewsGene locus BruAb1_0450 in contig AE017223_GR.
KEGGbmb:BruAb1_0450.
PATRIC17822482. VBIBruAbo15061_0478.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG292336.
OMASRFTTQR.
PhylomeDBQ57ET8.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycBABO262698:BRUAB1_0450-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_BRUAB
AccessionPrimary (citable) accession number: Q57ET8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 10, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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