Q57EQ8 (ACP_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl carrier protein
Short name=ACP

Gene names

Name:	acpP
Ordered Locus Names:	BruAb1_0481

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis By similarity. HAMAP-Rule MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP-Rule MF_01217
Subcellular location	Cytoplasm By similarity.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group By similarity. HAMAP-Rule MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	Acyl carrier protein HAMAP-Rule MF_01217		PRO_1000066567
Amino acid modifications
	Modified residue	37	1	O-(pantetheine 4'-phosphoryl)serine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57EQ8 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 5F2933B306AEE119	FASTA	78	8,301
	10 20 30 40 50 60 MSDTAERVKK IVVEHLGVDA DKVTEGASFI DDLGADSLDT VELVMAFEEE FGVEIPDDAA 70 ETILTVGDAV KFIDKASA

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX73876.1.
RefSeq	YP_221237.1. NC_006932.1.
3D structure databases
HSSP	HSSP built from PDB template 1T8K based on UniProtKB P0A6A8.
ProteinModelPortal	Q57EQ8.
SMR	Q57EQ8. Positions 6-75.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_0481.
Proteomic databases
PRIDE	Q57EQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX73876; AAX73876; BruAb1_0481.
GeneID	3339510.
KEGG	bmb:BruAb1_0481.
PATRIC	17822542. VBIBruAbo15061_0508.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0236.
HOGENOM	HOG000178184.
KO	K02078.
OMA	IETEEIT.
ProtClustDB	PRK00982.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-487-MONOMER.
UniPathway	UPA00094.
Family and domain databases
Gene3D	1.10.1200.10. 1 hit.
HAMAP	MF_01217. Acyl_carrier.
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006162. PPantetheine_attach_site. [Graphical view]
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. PD000887. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR00517. acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_BRUAB

Accession

Primary (citable) accession number: Q57EQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program