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Q57EP5 (KHSE_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:BruAb1_0498
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00301

Sequence similarities

Belongs to the pseudomonas-type ThrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Homoserine kinase HAMAP-Rule MF_00301
PRO_0000300782

Sequences

Sequence LengthMass (Da)Tools
Q57EP5 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 0503E8758D5F1AFA

FASTA32636,645
        10         20         30         40         50         60 
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 

        70         80         90        100        110        120 
DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 

       130        140        150        160        170        180 
VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 

       190        200        210        220        230        240 
WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 

       250        260        270        280        290        300 
RTKGAALLRG YTSVRPLSEA EADALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 

       310        320 
YVRRMRFHRQ IESAAEYGLE MQGVAA 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX73889.1.
RefSeqYP_221250.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ57EP5.
SMRQ57EP5. Positions 5-319.
ModBaseSearch...

Protein-protein interaction databases

STRING262698.BruAb1_0498.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX73889; AAX73889; BruAb1_0498.
GeneID3340114.
KEGGbmb:BruAb1_0498.
PATRIC17822580. VBIBruAbo15061_0527.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2334.
HOGENOMHOG000004810.
KOK02204.
OMAPDNVFFL.
ProtClustDBPRK05231.

Enzyme and pathway databases

BioCycBABO262698:GJC2-504-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
InterProIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
TIGRFAMsTIGR00938. thrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BRUAB
AccessionPrimary (citable) accession number: Q57EP5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 10, 2005
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families