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Protein

HTH-type transcriptional regulator BetI

Gene

betI

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
  2. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-582-MONOMER.
UniPathwayiUPA00529.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator BetIUniRule annotation
Gene namesi
Name:betIUniRule annotation
Ordered Locus Names:BruAb1_0576
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198HTH-type transcriptional regulator BetIPRO_0000257726Add
BLAST

Proteomic databases

PRIDEiQ57EH9.

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_0576.

Structurei

3D structure databases

ProteinModelPortaliQ57EH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6861HTH tetR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248227.
KOiK02167.
OMAiGIINHYF.
OrthoDBiEOG6FFS5N.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_00768. HTH_type_BetI.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57EH9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKIGMEPLR RRELIDAAIR TIGQRGSLDV TVAQIAHEAG VSPALAHHYF
60 70 80 90 100
GGKDKLILAT MRHLLRELGR DLNVAIKQAN TPHERIAAII AVNFSATQFA
110 120 130 140 150
QETIAAWLTF YVHAQQSDDI KRLLRIYARR LHSNLVFALE QLTSRARANR
160 170 180 190
IAEGAGAMID GLYIRHALGA DAPDAASAIA LVEDYIAIQL SGQPSAEN
Length:198
Mass (Da):21,678
Last modified:May 10, 2005 - v1
Checksum:i4C8AEC3346CA6337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73955.1.
RefSeqiYP_221316.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX73955; AAX73955; BruAb1_0576.
GeneIDi3341143.
KEGGibmb:BruAb1_0576.
PATRICi17822741. VBIBruAbo15061_0607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX73955.1.
RefSeqiYP_221316.1. NC_006932.1.

3D structure databases

ProteinModelPortaliQ57EH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_0576.

Proteomic databases

PRIDEiQ57EH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX73955; AAX73955; BruAb1_0576.
GeneIDi3341143.
KEGGibmb:BruAb1_0576.
PATRICi17822741. VBIBruAbo15061_0607.

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248227.
KOiK02167.
OMAiGIINHYF.
OrthoDBiEOG6FFS5N.

Enzyme and pathway databases

UniPathwayiUPA00529.
BioCyciBABO262698:GJC2-582-MONOMER.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_00768. HTH_type_BetI.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiBETI_BRUAB
AccessioniPrimary (citable) accession number: Q57EH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 10, 2005
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.