Q57EH9 (BETI_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HTH-type transcriptional regulator BetI

Gene names

Name:	betI
Ordered Locus Names:	BruAb1_0576

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Repressor involved in choline regulation of the bet genes By similarity. HAMAP-Rule MF_00768
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway [regulation]. HAMAP-Rule MF_00768
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: HAMAP transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	HTH-type transcriptional regulator BetI HAMAP-Rule MF_00768		PRO_0000257726
Regions
	Domain	8 – 68	61	HTH tetR-type
	DNA binding	31 – 50	20	H-T-H motif By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q57EH9 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 4C8AEC3346CA6337	FASTA	198	21,678
	10 20 30 40 50 60 MPKIGMEPLR RRELIDAAIR TIGQRGSLDV TVAQIAHEAG VSPALAHHYF GGKDKLILAT 70 80 90 100 110 120 MRHLLRELGR DLNVAIKQAN TPHERIAAII AVNFSATQFA QETIAAWLTF YVHAQQSDDI 130 140 150 160 170 180 KRLLRIYARR LHSNLVFALE QLTSRARANR IAEGAGAMID GLYIRHALGA DAPDAASAIA 190 LVEDYIAIQL SGQPSAEN

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX73955.1.
RefSeq	YP_221316.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57EH9.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_0576.
Proteomic databases
PRIDE	Q57EH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX73955; AAX73955; BruAb1_0576.
GeneID	3341143.
KEGG	bmb:BruAb1_0576.
PATRIC	17822741. VBIBruAbo15061_0607.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1309.
HOGENOM	HOG000248227.
KO	K02167.
OMA	INHYFGG.
ProtClustDB	PRK00767.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-582-MONOMER.
UniPathway	UPA00529.
Family and domain databases
Gene3D	1.10.357.10. 1 hit.
HAMAP	MF_00768. HTH-type_BetI.
InterPro	IPR023772. DNA-bd_HTH_TetR-type_CS. IPR009057. Homeodomain-like. IPR001647. HTH_TetR. IPR015893. Tet_transcr_reg_TetR-like_C. IPR011075. Tet_transcr_reg_TetR-rel_C. IPR017757. Tscrpt_rep_BetI. [Graphical view]
Pfam	PF00440. TetR_N. 1 hit. [Graphical view]
PRINTS	PR00455. HTHTETR.
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF48498. TetR_like_C. 1 hit.
TIGRFAMs	TIGR03384. betaine_BetI. 1 hit.
PROSITE	PS01081. HTH_TETR_1. 1 hit. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETI_BRUAB

Accession

Primary (citable) accession number: Q57EH9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program