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Protein

Heme A synthase

Gene

ctaA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group.UniRule annotation

Pathway: heme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme A from heme O.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Heme A synthase (ctaA)
This subpathway is part of the pathway heme A biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme A from heme O, the pathway heme A biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei334 – 3341SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Heme biosynthesis

Enzyme and pathway databases

BioCyciBABO262698:GJC2-811-MONOMER.
UniPathwayiUPA00269; UER00713.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme A synthaseUniRule annotation (EC:1.3.-.-UniRule annotation)
Short name:
HASUniRule annotation
Alternative name(s):
Cytochrome aa3-controlling proteinUniRule annotation
Gene namesi
Name:ctaAUniRule annotation
Ordered Locus Names:BruAb1_0801
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome I

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei176 – 19621HelicalUniRule annotationAdd
BLAST
Transmembranei210 – 23021HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST
Transmembranei304 – 32421HelicalUniRule annotationAdd
BLAST
Transmembranei326 – 34621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Heme A synthasePRO_0000349020Add
BLAST

Interactioni

Subunit structurei

Interacts with CtaB.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1612.
HOGENOMiHOG000214943.
KOiK02259.
OMAiWIMARRS.
OrthoDBiEOG6KMB6V.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATSAQHIG LQGHGTSRND RDRRLVRYWL YAVFAVLIAI VMVGGATRMT
60 70 80 90 100
GSGLSITEWK PIHGVIPPLN HAEWVEEFEK YQQIPQYQQI NKGMSLAEFQ
110 120 130 140 150
YIFWWEWAHR LLARFVGFLV AVPLGFFWLT GRLKGGLKYR MLGLLALGGL
160 170 180 190 200
QGAIGWWMVA SGLSELTSVS QYRLAIHLTT ACVIITAVFY IARGLVTYSE
210 220 230 240 250
RPAERSIQRF AGWIVFAVLV QIYLGGLVAG LHAGLTYNTW PLMDGAIIPS
260 270 280 290 300
DLFTQAPWWR NLFENPKTVQ FVHRMFAYTV LLLAILHAVQ VWKNAPGTTH
310 320 330 340 350
ARRTIVLVGL VFIQAMIGIA TLLMSAPLHL GLTHQFFALV VLAFAVAHWR

ATKGAYAA
Length:358
Mass (Da):40,048
Last modified:May 10, 2005 - v1
Checksum:i4DF7F2FBFAF09798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74169.1.
RefSeqiWP_002969419.1. NC_006932.1.
YP_221530.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74169; AAX74169; BruAb1_0801.
GeneIDi3787503.
KEGGibmb:BruAb1_0801.
PATRICi17823222. VBIBruAbo15061_0844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74169.1.
RefSeqiWP_002969419.1. NC_006932.1.
YP_221530.1. NC_006932.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX74169; AAX74169; BruAb1_0801.
GeneIDi3787503.
KEGGibmb:BruAb1_0801.
PATRICi17823222. VBIBruAbo15061_0844.

Phylogenomic databases

eggNOGiCOG1612.
HOGENOMiHOG000214943.
KOiK02259.
OMAiWIMARRS.
OrthoDBiEOG6KMB6V.

Enzyme and pathway databases

UniPathwayiUPA00269; UER00713.
BioCyciBABO262698:GJC2-811-MONOMER.

Family and domain databases

HAMAPiMF_01665. HemeA_synth_type2.
InterProiIPR003780. COX15/CtaA_fam.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamiPF02628. COX15-CtaA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiCTAA_BRUAB
AccessioniPrimary (citable) accession number: Q57DW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: June 24, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.