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Q57DW5 (CTAA_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme A synthase

Short name=HAS
EC=1.3.-.-
Alternative name(s):
Cytochrome aa3-controlling protein
Gene names
Name:ctaA
Ordered Locus Names:BruAb1_0801
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group By similarity. HAMAP-Rule MF_01665

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. HAMAP-Rule MF_01665

Subunit structure

Interacts with CtaB By similarity. HAMAP-Rule MF_01665

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01665.

Sequence similarities

Belongs to the COX15/CtaA family. Type 2 subfamily.

Ontologies

Keywords
   Biological processHeme biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme a biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxidoreductase activity, acting on the CH-CH group of donors

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Heme A synthase HAMAP-Rule MF_01665
PRO_0000349020

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane304 – 32421Helical; Potential
Transmembrane326 – 34621Helical; Potential

Sites

Binding site3341Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q57DW5 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 4DF7F2FBFAF09798

FASTA35840,048
        10         20         30         40         50         60 
MAATSAQHIG LQGHGTSRND RDRRLVRYWL YAVFAVLIAI VMVGGATRMT GSGLSITEWK 

        70         80         90        100        110        120 
PIHGVIPPLN HAEWVEEFEK YQQIPQYQQI NKGMSLAEFQ YIFWWEWAHR LLARFVGFLV 

       130        140        150        160        170        180 
AVPLGFFWLT GRLKGGLKYR MLGLLALGGL QGAIGWWMVA SGLSELTSVS QYRLAIHLTT 

       190        200        210        220        230        240 
ACVIITAVFY IARGLVTYSE RPAERSIQRF AGWIVFAVLV QIYLGGLVAG LHAGLTYNTW 

       250        260        270        280        290        300 
PLMDGAIIPS DLFTQAPWWR NLFENPKTVQ FVHRMFAYTV LLLAILHAVQ VWKNAPGTTH 

       310        320        330        340        350 
ARRTIVLVGL VFIQAMIGIA TLLMSAPLHL GLTHQFFALV VLAFAVAHWR ATKGAYAA 

« Hide

References

[1]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017223 Genomic DNA. Translation: AAX74169.1.
RefSeqYP_221530.1. NC_006932.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262698.BruAb1_0801.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX74169; AAX74169; BruAb1_0801.
GeneID3339955.
KEGGbmb:BruAb1_0801.
PATRIC17823222. VBIBruAbo15061_0844.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1612.
HOGENOMHOG000214943.
KOK02259.
OMAEEFRLYQ.
OrthoDBEOG6KMB6V.

Enzyme and pathway databases

BioCycBABO262698:GJC2-811-MONOMER.
UniPathwayUPA00269; UER00713.

Family and domain databases

HAMAPMF_01665. HemeA_synth_type2.
InterProIPR003780. HemeA_syn.
IPR023754. HemeA_Synthase_type2.
[Graphical view]
PfamPF02628. COX15-CtaA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTAA_BRUAB
AccessionPrimary (citable) accession number: Q57DW5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names