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Q57DW5

- CTAA_BRUAB

UniProt

Q57DW5 - CTAA_BRUAB

Protein

Heme A synthase

Gene

ctaA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei334 – 3341SubstrateUniRule annotation

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-CH group of donors Source: InterPro

    GO - Biological processi

    1. heme a biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Heme biosynthesis

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-811-MONOMER.
    UniPathwayiUPA00269; UER00713.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme A synthaseUniRule annotation (EC:1.3.-.-UniRule annotation)
    Short name:
    HASUniRule annotation
    Alternative name(s):
    Cytochrome aa3-controlling proteinUniRule annotation
    Gene namesi
    Name:ctaAUniRule annotation
    Ordered Locus Names:BruAb1_0801
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Heme A synthasePRO_0000349020Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with CtaB.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0801.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalUniRule annotationAdd
    BLAST
    Transmembranei111 – 13121HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei176 – 19621HelicalUniRule annotationAdd
    BLAST
    Transmembranei210 – 23021HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 28921HelicalUniRule annotationAdd
    BLAST
    Transmembranei304 – 32421HelicalUniRule annotationAdd
    BLAST
    Transmembranei326 – 34621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the COX15/CtaA family. Type 2 subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1612.
    HOGENOMiHOG000214943.
    KOiK02259.
    OMAiEEFRLYQ.
    OrthoDBiEOG6KMB6V.

    Family and domain databases

    HAMAPiMF_01665. HemeA_synth_type2.
    InterProiIPR003780. COX15/CtaA_fam.
    IPR023754. HemeA_Synthase_type2.
    [Graphical view]
    PfamiPF02628. COX15-CtaA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57DW5-1 [UniParc]FASTAAdd to Basket

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    MAATSAQHIG LQGHGTSRND RDRRLVRYWL YAVFAVLIAI VMVGGATRMT    50
    GSGLSITEWK PIHGVIPPLN HAEWVEEFEK YQQIPQYQQI NKGMSLAEFQ 100
    YIFWWEWAHR LLARFVGFLV AVPLGFFWLT GRLKGGLKYR MLGLLALGGL 150
    QGAIGWWMVA SGLSELTSVS QYRLAIHLTT ACVIITAVFY IARGLVTYSE 200
    RPAERSIQRF AGWIVFAVLV QIYLGGLVAG LHAGLTYNTW PLMDGAIIPS 250
    DLFTQAPWWR NLFENPKTVQ FVHRMFAYTV LLLAILHAVQ VWKNAPGTTH 300
    ARRTIVLVGL VFIQAMIGIA TLLMSAPLHL GLTHQFFALV VLAFAVAHWR 350
    ATKGAYAA 358
    Length:358
    Mass (Da):40,048
    Last modified:May 10, 2005 - v1
    Checksum:i4DF7F2FBFAF09798
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74169.1.
    RefSeqiYP_221530.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74169; AAX74169; BruAb1_0801.
    GeneIDi3339955.
    KEGGibmb:BruAb1_0801.
    PATRICi17823222. VBIBruAbo15061_0844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74169.1 .
    RefSeqi YP_221530.1. NC_006932.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0801.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74169 ; AAX74169 ; BruAb1_0801 .
    GeneIDi 3339955.
    KEGGi bmb:BruAb1_0801.
    PATRICi 17823222. VBIBruAbo15061_0844.

    Phylogenomic databases

    eggNOGi COG1612.
    HOGENOMi HOG000214943.
    KOi K02259.
    OMAi EEFRLYQ.
    OrthoDBi EOG6KMB6V.

    Enzyme and pathway databases

    UniPathwayi UPA00269 ; UER00713 .
    BioCyci BABO262698:GJC2-811-MONOMER.

    Family and domain databases

    HAMAPi MF_01665. HemeA_synth_type2.
    InterProi IPR003780. COX15/CtaA_fam.
    IPR023754. HemeA_Synthase_type2.
    [Graphical view ]
    Pfami PF02628. COX15-CtaA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiCTAA_BRUAB
    AccessioniPrimary (citable) accession number: Q57DW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3