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Protein

Heme A synthase

Gene

ctaA

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group.UniRule annotation

Pathwayi: heme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes heme A from heme O.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Heme A synthase (ctaA)
This subpathway is part of the pathway heme A biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes heme A from heme O, the pathway heme A biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei334SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processHeme biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00269; UER00713

Names & Taxonomyi

Protein namesi
Recommended name:
Heme A synthaseUniRule annotation (EC:1.3.-.-UniRule annotation)
Short name:
HASUniRule annotation
Alternative name(s):
Cytochrome aa3-controlling proteinUniRule annotation
Gene namesi
Name:ctaAUniRule annotation
Ordered Locus Names:BruAb1_0801
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei111 – 131HelicalUniRule annotationAdd BLAST21
Transmembranei141 – 161HelicalUniRule annotationAdd BLAST21
Transmembranei176 – 196HelicalUniRule annotationAdd BLAST21
Transmembranei210 – 230HelicalUniRule annotationAdd BLAST21
Transmembranei269 – 289HelicalUniRule annotationAdd BLAST21
Transmembranei304 – 324HelicalUniRule annotationAdd BLAST21
Transmembranei326 – 346HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003490201 – 358Heme A synthaseAdd BLAST358

Interactioni

Subunit structurei

Interacts with CtaB.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the COX15/CtaA family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000214943
KOiK02259
OMAiAGLIYNT

Family and domain databases

HAMAPiMF_01665 HemeA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR003780 COX15/CtaA_fam
IPR023754 HemeA_Synthase_type2
PANTHERiPTHR23289 PTHR23289, 1 hit
PfamiView protein in Pfam
PF02628 COX15-CtaA, 1 hit

Sequencei

Sequence statusi: Complete.

Q57DW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATSAQHIG LQGHGTSRND RDRRLVRYWL YAVFAVLIAI VMVGGATRMT
60 70 80 90 100
GSGLSITEWK PIHGVIPPLN HAEWVEEFEK YQQIPQYQQI NKGMSLAEFQ
110 120 130 140 150
YIFWWEWAHR LLARFVGFLV AVPLGFFWLT GRLKGGLKYR MLGLLALGGL
160 170 180 190 200
QGAIGWWMVA SGLSELTSVS QYRLAIHLTT ACVIITAVFY IARGLVTYSE
210 220 230 240 250
RPAERSIQRF AGWIVFAVLV QIYLGGLVAG LHAGLTYNTW PLMDGAIIPS
260 270 280 290 300
DLFTQAPWWR NLFENPKTVQ FVHRMFAYTV LLLAILHAVQ VWKNAPGTTH
310 320 330 340 350
ARRTIVLVGL VFIQAMIGIA TLLMSAPLHL GLTHQFFALV VLAFAVAHWR

ATKGAYAA
Length:358
Mass (Da):40,048
Last modified:May 10, 2005 - v1
Checksum:i4DF7F2FBFAF09798
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX74169.1
RefSeqiWP_002969419.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX74169; AAX74169; BruAb1_0801
GeneIDi29594016
KEGGibmb:BruAb1_0801

Similar proteinsi

Entry informationi

Entry nameiCTAA_BRUAB
AccessioniPrimary (citable) accession number: Q57DW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health