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Q57DM2

- SYS_BRUAB

UniProt

Q57DM2 - SYS_BRUAB

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Protein
Serine--tRNA ligase
Gene
serS, BruAb1_0897
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity.UniRule annotation

Catalytic activityi

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).UniRule annotation
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei285 – 2851Serine By similarity
Binding sitei385 – 3851Serine By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi262 – 2643ATP By similarity
Nucleotide bindingi349 – 3524ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. serine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. selenocysteine biosynthetic process Source: UniProtKB-HAMAP
  2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway
  3. seryl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-909-MONOMER.
UniPathwayiUPA00906; UER00895.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--tRNA ligase (EC:6.1.1.11)
Alternative name(s):
Seryl-tRNA synthetase
Short name:
SerRS
Seryl-tRNA(Ser/Sec) synthetase
Gene namesi
Name:serS
Ordered Locus Names:BruAb1_0897
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Serine--tRNA ligaseUniRule annotation
PRO_1000019626Add
BLAST

Proteomic databases

PRIDEiQ57DM2.

Interactioni

Subunit structurei

Homodimer. The tRNA molecule binds across the dimer By similarity.

Protein-protein interaction databases

STRINGi262698.BruAb1_0897.

Structurei

3D structure databases

ProteinModelPortaliQ57DM2.
SMRiQ57DM2. Positions 1-424.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni231 – 2333Serine binding By similarity

Domaini

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0172.
HOGENOMiHOG000035938.
KOiK01875.
OMAiQMRTEEL.
OrthoDBiEOG61KBH9.

Family and domain databases

Gene3Di1.10.287.40. 1 hit.
HAMAPiMF_00176. Ser_tRNA_synth_type1.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERiPTHR11778. PTHR11778. 1 hit.
PfamiPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFiPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSiPR00981. TRNASYNTHSER.
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00414. serS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DM2-1 [UniParc]FASTAAdd to Basket

« Hide

MLDIKWIREN PETLDKALAK RGAAPLSSEL IALDEKRREH VGKVQAAQER    50
RNAASKEIGK AMAAKDMGTA EKLKAEVGEL KDFLAHAEED ERRLSKELSD 100
ALSTIPNIPL DDVPLGKDES DNVELRRIGN PHNFSFQPKE HFELGEALGY 150
MDFERAAKLA GARFTVLKGP LARLERALGQ FMLDLHTTEH GYTEVMPPLM 200
VRDEAVYGTG QLPKFSEDLF RTTDGRWLIP TAEVPLTNLV AEEIVDMKGL 250
PLRFTALTPC FRSEAGSAGR DTRGMLRQHQ FLKVEMVSIT DAESSVAEHE 300
RMTACAEEVL KRLGLPFRTV VLCTGDMGFG AQRTYDIEVW LPGQNTYREI 350
SSCSTCGDFQ GRRMNARYRP EGEKSTRFVH TLNGSGVAVG RALIAVMENY 400
QQEDGSIHIP EALQPYMGGL TRIEKAA 427
Length:427
Mass (Da):47,548
Last modified:May 10, 2005 - v1
Checksum:i9452FF0D8CA3F376
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74262.1.
RefSeqiYP_221623.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74262; AAX74262; BruAb1_0897.
GeneIDi3339513.
KEGGibmb:BruAb1_0897.
PATRICi17823422. VBIBruAbo15061_0942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74262.1 .
RefSeqi YP_221623.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57DM2.
SMRi Q57DM2. Positions 1-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0897.

Proteomic databases

PRIDEi Q57DM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74262 ; AAX74262 ; BruAb1_0897 .
GeneIDi 3339513.
KEGGi bmb:BruAb1_0897.
PATRICi 17823422. VBIBruAbo15061_0942.

Phylogenomic databases

eggNOGi COG0172.
HOGENOMi HOG000035938.
KOi K01875.
OMAi QMRTEEL.
OrthoDBi EOG61KBH9.

Enzyme and pathway databases

UniPathwayi UPA00906 ; UER00895 .
BioCyci BABO262698:GJC2-909-MONOMER.

Family and domain databases

Gene3Di 1.10.287.40. 1 hit.
HAMAPi MF_00176. Ser_tRNA_synth_type1.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view ]
PANTHERi PTHR11778. PTHR11778. 1 hit.
Pfami PF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PIRSFi PIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSi PR00981. TRNASYNTHSER.
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00414. serS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiSYS_BRUAB
AccessioniPrimary (citable) accession number: Q57DM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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