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Q57DM2

- SYS_BRUAB

UniProt

Q57DM2 - SYS_BRUAB

Protein

Serine--tRNA ligase

Gene

serS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).UniRule annotation

    Catalytic activityi

    ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).UniRule annotation
    ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei285 – 2851SerineUniRule annotation
    Binding sitei385 – 3851SerineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi262 – 2643ATPUniRule annotation
    Nucleotide bindingi349 – 3524ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. serine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. selenocysteine biosynthetic process Source: UniProtKB-HAMAP
    2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway
    3. seryl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-909-MONOMER.
    UniPathwayiUPA00906; UER00895.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine--tRNA ligaseUniRule annotation (EC:6.1.1.11UniRule annotation)
    Alternative name(s):
    Seryl-tRNA synthetaseUniRule annotation
    Short name:
    SerRSUniRule annotation
    Seryl-tRNA(Ser/Sec) synthetaseUniRule annotation
    Gene namesi
    Name:serSUniRule annotation
    Ordered Locus Names:BruAb1_0897
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Serine--tRNA ligasePRO_1000019626Add
    BLAST

    Proteomic databases

    PRIDEiQ57DM2.

    Interactioni

    Subunit structurei

    Homodimer. The tRNA molecule binds across the dimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57DM2.
    SMRiQ57DM2. Positions 1-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni231 – 2333Serine bindingUniRule annotation

    Domaini

    Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0172.
    HOGENOMiHOG000035938.
    KOiK01875.
    OMAiQMRTEEL.
    OrthoDBiEOG61KBH9.

    Family and domain databases

    Gene3Di1.10.287.40. 1 hit.
    HAMAPiMF_00176. Ser_tRNA_synth_type1.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR002317. Ser-tRNA-ligase_type_1.
    IPR015866. Ser-tRNA-synth_1_N.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PANTHERiPTHR11778. PTHR11778. 1 hit.
    PfamiPF02403. Seryl_tRNA_N. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
    PRINTSiPR00981. TRNASYNTHSER.
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00414. serS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57DM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDIKWIREN PETLDKALAK RGAAPLSSEL IALDEKRREH VGKVQAAQER    50
    RNAASKEIGK AMAAKDMGTA EKLKAEVGEL KDFLAHAEED ERRLSKELSD 100
    ALSTIPNIPL DDVPLGKDES DNVELRRIGN PHNFSFQPKE HFELGEALGY 150
    MDFERAAKLA GARFTVLKGP LARLERALGQ FMLDLHTTEH GYTEVMPPLM 200
    VRDEAVYGTG QLPKFSEDLF RTTDGRWLIP TAEVPLTNLV AEEIVDMKGL 250
    PLRFTALTPC FRSEAGSAGR DTRGMLRQHQ FLKVEMVSIT DAESSVAEHE 300
    RMTACAEEVL KRLGLPFRTV VLCTGDMGFG AQRTYDIEVW LPGQNTYREI 350
    SSCSTCGDFQ GRRMNARYRP EGEKSTRFVH TLNGSGVAVG RALIAVMENY 400
    QQEDGSIHIP EALQPYMGGL TRIEKAA 427
    Length:427
    Mass (Da):47,548
    Last modified:May 10, 2005 - v1
    Checksum:i9452FF0D8CA3F376
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74262.1.
    RefSeqiYP_221623.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74262; AAX74262; BruAb1_0897.
    GeneIDi3339513.
    KEGGibmb:BruAb1_0897.
    PATRICi17823422. VBIBruAbo15061_0942.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74262.1 .
    RefSeqi YP_221623.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57DM2.
    SMRi Q57DM2. Positions 1-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0897.

    Proteomic databases

    PRIDEi Q57DM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74262 ; AAX74262 ; BruAb1_0897 .
    GeneIDi 3339513.
    KEGGi bmb:BruAb1_0897.
    PATRICi 17823422. VBIBruAbo15061_0942.

    Phylogenomic databases

    eggNOGi COG0172.
    HOGENOMi HOG000035938.
    KOi K01875.
    OMAi QMRTEEL.
    OrthoDBi EOG61KBH9.

    Enzyme and pathway databases

    UniPathwayi UPA00906 ; UER00895 .
    BioCyci BABO262698:GJC2-909-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.40. 1 hit.
    HAMAPi MF_00176. Ser_tRNA_synth_type1.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR002317. Ser-tRNA-ligase_type_1.
    IPR015866. Ser-tRNA-synth_1_N.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    PANTHERi PTHR11778. PTHR11778. 1 hit.
    Pfami PF02403. Seryl_tRNA_N. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
    PRINTSi PR00981. TRNASYNTHSER.
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00414. serS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiSYS_BRUAB
    AccessioniPrimary (citable) accession number: Q57DM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3