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Q57DK9

- TIG_BRUAB

UniProt

Q57DK9 - TIG_BRUAB

Protein

Trigger factor

Gene

tig

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (31 Oct 2006)
      Previous versions | rss
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    Functioni

    Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. protein folding Source: UniProtKB-HAMAP
    4. protein transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-923-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
    Short name:
    TFUniRule annotation
    Alternative name(s):
    PPIaseUniRule annotation
    Gene namesi
    Name:tigUniRule annotation
    Ordered Locus Names:BruAb1_0910
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm
    Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 471471Trigger factorPRO_0000256532Add
    BLAST

    Proteomic databases

    PRIDEiQ57DK9.

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0910.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57DK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 25486PPIase FKBP-typeUniRule annotationAdd
    BLAST

    Domaini

    Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
    Contains 1 PPIase FKBP-type domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0544.
    HOGENOMiHOG000218241.
    KOiK03545.
    OMAiWAVIDHE.
    OrthoDBiEOG63VBX3.

    Family and domain databases

    Gene3Di1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPiMF_00303. Trigger_factor_Tig.
    InterProiIPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view]
    PfamiPF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003095. Trigger_factor. 1 hit.
    SUPFAMiSSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsiTIGR00115. tig. 1 hit.
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57DK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVTETLNEG LKREIKVVVP AGDLEAKLAE RLETARGRAR INGFRPGKVP    50
    TAHLRKMYGK SFMAEIVNEI LNDSSRSILA ERNEKSATQP EVIMSEDEKE 100
    AEKVLDGKAD FVFSLNYEVL PAIEVKDFSK IAVTREVVDI SDEEVDEQVK 150
    RIASSTRTFE TKKGKAENED RVTIDYLGKL DGEPFEGGAD NDAQLVLGSG 200
    QFIPGFEEQL IGLKAGDEKV ITVTFPAEYG AAHLAGKEAT FDIKVKEVAK 250
    PNELVLDDET AKKLGIESLE RLRQVVREQI ESQYGQITRQ KVKRQILDAL 300
    DGDYQFETPQ KLVDAEFNNI WQQINFDLQQ AGRTFEDEET TEEAAREEYR 350
    KLAERRVRLG LVLSEIGEKA GVEVTEEELQ RAVYDQVRRY PGQEKEIYDF 400
    LRRTPDAVAN LRAPIFEEKV VDHLLANINV TDKKVSKEEL TAEDEDAASE 450
    AKPAKKAAAK KKAEEGKSEE A 471
    Length:471
    Mass (Da):52,937
    Last modified:October 31, 2006 - v2
    Checksum:iAED56918C5642E41
    GO

    Sequence cautioni

    The sequence AAX74275.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74275.1. Different initiation.
    RefSeqiYP_221636.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74275; AAX74275; BruAb1_0910.
    GeneIDi3340906.
    KEGGibmb:BruAb1_0910.
    PATRICi17823454. VBIBruAbo15061_0957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74275.1 . Different initiation.
    RefSeqi YP_221636.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57DK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0910.

    Proteomic databases

    PRIDEi Q57DK9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74275 ; AAX74275 ; BruAb1_0910 .
    GeneIDi 3340906.
    KEGGi bmb:BruAb1_0910.
    PATRICi 17823454. VBIBruAbo15061_0957.

    Phylogenomic databases

    eggNOGi COG0544.
    HOGENOMi HOG000218241.
    KOi K03545.
    OMAi WAVIDHE.
    OrthoDBi EOG63VBX3.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-923-MONOMER.

    Miscellaneous databases

    PROi Q57DK9.

    Family and domain databases

    Gene3Di 1.10.3120.10. 1 hit.
    3.30.70.1050. 1 hit.
    HAMAPi MF_00303. Trigger_factor_Tig.
    InterProi IPR001179. PPIase_FKBP_dom.
    IPR005215. Trig_fac.
    IPR008880. Trigger_fac_C.
    IPR008881. Trigger_fac_ribosome-bd_bac.
    IPR027304. Trigger_fact/SurA_dom.
    [Graphical view ]
    Pfami PF00254. FKBP_C. 1 hit.
    PF05698. Trigger_C. 1 hit.
    PF05697. Trigger_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003095. Trigger_factor. 1 hit.
    SUPFAMi SSF102735. SSF102735. 1 hit.
    SSF109998. SSF109998. 1 hit.
    TIGRFAMsi TIGR00115. tig. 1 hit.
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiTIG_BRUAB
    AccessioniPrimary (citable) accession number: Q57DK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3