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Q57DK9

- TIG_BRUAB

UniProt

Q57DK9 - TIG_BRUAB

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Protein

Trigger factor

Gene

tig

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. protein folding Source: UniProtKB-HAMAP
  4. protein transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciBABO262698:GJC2-923-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trigger factorUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
TFUniRule annotation
Alternative name(s):
PPIaseUniRule annotation
Gene namesi
Name:tigUniRule annotation
Ordered Locus Names:BruAb1_0910
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm
Note: About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Trigger factorPRO_0000256532Add
BLAST

Proteomic databases

PRIDEiQ57DK9.

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_0910.

Structurei

3D structure databases

ProteinModelPortaliQ57DK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 25486PPIase FKBP-typeUniRule annotationAdd
BLAST

Domaini

Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.UniRule annotation

Sequence similaritiesi

Belongs to the FKBP-type PPIase family. Tig subfamily.UniRule annotation
Contains 1 PPIase FKBP-type domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0544.
HOGENOMiHOG000218241.
KOiK03545.
OMAiWAVIDHE.
OrthoDBiEOG63VBX3.

Family and domain databases

Gene3Di1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPiMF_00303. Trigger_factor_Tig.
InterProiIPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view]
PIRSFiPIRSF003095. Trigger_factor. 1 hit.
SUPFAMiSSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsiTIGR00115. tig. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVTETLNEG LKREIKVVVP AGDLEAKLAE RLETARGRAR INGFRPGKVP
60 70 80 90 100
TAHLRKMYGK SFMAEIVNEI LNDSSRSILA ERNEKSATQP EVIMSEDEKE
110 120 130 140 150
AEKVLDGKAD FVFSLNYEVL PAIEVKDFSK IAVTREVVDI SDEEVDEQVK
160 170 180 190 200
RIASSTRTFE TKKGKAENED RVTIDYLGKL DGEPFEGGAD NDAQLVLGSG
210 220 230 240 250
QFIPGFEEQL IGLKAGDEKV ITVTFPAEYG AAHLAGKEAT FDIKVKEVAK
260 270 280 290 300
PNELVLDDET AKKLGIESLE RLRQVVREQI ESQYGQITRQ KVKRQILDAL
310 320 330 340 350
DGDYQFETPQ KLVDAEFNNI WQQINFDLQQ AGRTFEDEET TEEAAREEYR
360 370 380 390 400
KLAERRVRLG LVLSEIGEKA GVEVTEEELQ RAVYDQVRRY PGQEKEIYDF
410 420 430 440 450
LRRTPDAVAN LRAPIFEEKV VDHLLANINV TDKKVSKEEL TAEDEDAASE
460 470
AKPAKKAAAK KKAEEGKSEE A
Length:471
Mass (Da):52,937
Last modified:October 31, 2006 - v2
Checksum:iAED56918C5642E41
GO

Sequence cautioni

The sequence AAX74275.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74275.1. Different initiation.
RefSeqiYP_221636.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74275; AAX74275; BruAb1_0910.
GeneIDi3340906.
KEGGibmb:BruAb1_0910.
PATRICi17823454. VBIBruAbo15061_0957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74275.1 . Different initiation.
RefSeqi YP_221636.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57DK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0910.

Proteomic databases

PRIDEi Q57DK9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74275 ; AAX74275 ; BruAb1_0910 .
GeneIDi 3340906.
KEGGi bmb:BruAb1_0910.
PATRICi 17823454. VBIBruAbo15061_0957.

Phylogenomic databases

eggNOGi COG0544.
HOGENOMi HOG000218241.
KOi K03545.
OMAi WAVIDHE.
OrthoDBi EOG63VBX3.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-923-MONOMER.

Miscellaneous databases

PROi Q57DK9.

Family and domain databases

Gene3Di 1.10.3120.10. 1 hit.
3.30.70.1050. 1 hit.
HAMAPi MF_00303. Trigger_factor_Tig.
InterProi IPR001179. PPIase_FKBP_dom.
IPR005215. Trig_fac.
IPR008880. Trigger_fac_C.
IPR008881. Trigger_fac_ribosome-bd_bac.
IPR027304. Trigger_fact/SurA_dom.
[Graphical view ]
Pfami PF00254. FKBP_C. 1 hit.
PF05698. Trigger_C. 1 hit.
PF05697. Trigger_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF003095. Trigger_factor. 1 hit.
SUPFAMi SSF102735. SSF102735. 1 hit.
SSF109998. SSF109998. 1 hit.
TIGRFAMsi TIGR00115. tig. 1 hit.
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiTIG_BRUAB
AccessioniPrimary (citable) accession number: Q57DK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3