Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q57DI5

- SYY_BRUAB

UniProt

Q57DI5 - SYY_BRUAB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391TyrosineUniRule annotation
Binding sitei176 – 1761TyrosineUniRule annotation
Binding sitei180 – 1801TyrosineUniRule annotation
Binding sitei239 – 2391ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-KW
  3. tyrosine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tyrosyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-949-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:BruAb1_0935
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Tyrosine--tRNA ligasePRO_0000234688Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0935.

Structurei

3D structure databases

ProteinModelPortaliQ57DI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini350 – 41768S4 RNA-bindingUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 5310"HIGH" region
Motifi236 – 2405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation
Contains 1 S4 RNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0162.
HOGENOMiHOG000242790.
KOiK01866.
OMAiTTIRYNS.
OrthoDBiEOG6B09VR.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_02006. Tyr_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024107. Tyr-tRNA-ligase_bac_1.
[Graphical view]
PANTHERiPTHR11766. PTHR11766. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01040. TRNASYNTHTYR.
TIGRFAMsiTIGR00234. tyrS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGFKSDFLR TLSERGFIHQ ISDESGLDEL LAKETVTAYI GFDPTAPSLH
60 70 80 90 100
AGGLIQIMML YWLQQTGHKP VALMGGGTGM VGDPSFKDEA RKLMTEDTIA
110 120 130 140 150
ENMASIKRVF ANYLTFGDGA NDALMVNNGE WLRNINYLEF LRDVGRHFSV
160 170 180 190 200
NRMLSFDSVK LRLDREQSLS FLEFNYMILQ AYDFVELNKR YGLRLQMGGS
210 220 230 240 250
DQWGNIVNGI DLGHRMGTPQ LYALTSPLLT TASGQKMGKS LGGAIWLNAD
260 270 280 290 300
MLSAYDFWQY WRNTEDADVE RFLKLYTTLP LDEIARLAEL GGAEINEAKK
310 320 330 340 350
ILATEVTAML HGRDAAEEAA ETARKTFEDG ELSENLPTVG VHKATLNDGI
360 370 380 390 400
GVLALMVLAE LCTTNGEARR HVEGGAVRIN DEPVSDPRMV VNAAALNDQG
410
LIKLSLGKKR HVLIRPA
Length:417
Mass (Da):46,157
Last modified:May 10, 2005 - v1
Checksum:i2D734F3E7A2D83EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74299.1.
RefSeqiYP_221660.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74299; AAX74299; BruAb1_0935.
GeneIDi3341098.
KEGGibmb:BruAb1_0935.
PATRICi17823508. VBIBruAbo15061_0984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74299.1 .
RefSeqi YP_221660.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57DI5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74299 ; AAX74299 ; BruAb1_0935 .
GeneIDi 3341098.
KEGGi bmb:BruAb1_0935.
PATRICi 17823508. VBIBruAbo15061_0984.

Phylogenomic databases

eggNOGi COG0162.
HOGENOMi HOG000242790.
KOi K01866.
OMAi TTIRYNS.
OrthoDBi EOG6B09VR.

Enzyme and pathway databases

BioCyci BABO262698:GJC2-949-MONOMER.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_02006. Tyr_tRNA_synth_type1.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002942. S4_RNA-bd.
IPR002307. Tyr-tRNA-ligase.
IPR024088. Tyr-tRNA-ligase_bac-type.
IPR024107. Tyr-tRNA-ligase_bac_1.
[Graphical view ]
PANTHERi PTHR11766. PTHR11766. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01040. TRNASYNTHTYR.
TIGRFAMsi TIGR00234. tyrS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiSYY_BRUAB
AccessioniPrimary (citable) accession number: Q57DI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3