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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39TyrosineUniRule annotation1
Binding sitei176TyrosineUniRule annotation1
Binding sitei180TyrosineUniRule annotation1
Binding sitei239ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:BruAb1_0935
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002346881 – 417Tyrosine--tRNA ligaseAdd BLAST417

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ57DI5
SMRiQ57DI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini350 – 417S4 RNA-bindingUniRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 53"HIGH" region10
Motifi236 – 240"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242790
KOiK01866
OMAiVNYMMAK

Family and domain databases

CDDicd00165 S4, 1 hit
cd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02006 Tyr_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
IPR024107 Tyr-tRNA-ligase_bac_1
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Q57DI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFKSDFLR TLSERGFIHQ ISDESGLDEL LAKETVTAYI GFDPTAPSLH
60 70 80 90 100
AGGLIQIMML YWLQQTGHKP VALMGGGTGM VGDPSFKDEA RKLMTEDTIA
110 120 130 140 150
ENMASIKRVF ANYLTFGDGA NDALMVNNGE WLRNINYLEF LRDVGRHFSV
160 170 180 190 200
NRMLSFDSVK LRLDREQSLS FLEFNYMILQ AYDFVELNKR YGLRLQMGGS
210 220 230 240 250
DQWGNIVNGI DLGHRMGTPQ LYALTSPLLT TASGQKMGKS LGGAIWLNAD
260 270 280 290 300
MLSAYDFWQY WRNTEDADVE RFLKLYTTLP LDEIARLAEL GGAEINEAKK
310 320 330 340 350
ILATEVTAML HGRDAAEEAA ETARKTFEDG ELSENLPTVG VHKATLNDGI
360 370 380 390 400
GVLALMVLAE LCTTNGEARR HVEGGAVRIN DEPVSDPRMV VNAAALNDQG
410
LIKLSLGKKR HVLIRPA
Length:417
Mass (Da):46,157
Last modified:May 10, 2005 - v1
Checksum:i2D734F3E7A2D83EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA Translation: AAX74299.1
RefSeqiWP_002964050.1, NC_006932.1

Genome annotation databases

EnsemblBacteriaiAAX74299; AAX74299; BruAb1_0935
GeneIDi29593869
KEGGibmb:BruAb1_0935

Similar proteinsi

Entry informationi

Entry nameiSYY_BRUAB
AccessioniPrimary (citable) accession number: Q57DI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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