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Q57DI5

- SYY_BRUAB

UniProt

Q57DI5 - SYY_BRUAB

Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

    Catalytic activityi

    ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391TyrosineUniRule annotation
    Binding sitei176 – 1761TyrosineUniRule annotation
    Binding sitei180 – 1801TyrosineUniRule annotation
    Binding sitei239 – 2391ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-KW
    3. tyrosine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tyrosyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-949-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
    Alternative name(s):
    Tyrosyl-tRNA synthetaseUniRule annotation
    Short name:
    TyrRSUniRule annotation
    Gene namesi
    Name:tyrSUniRule annotation
    Ordered Locus Names:BruAb1_0935
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Tyrosine--tRNA ligasePRO_0000234688Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_0935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ57DI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini350 – 41768S4 RNA-bindingUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5310"HIGH" region
    Motifi236 – 2405"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation
    Contains 1 S4 RNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0162.
    HOGENOMiHOG000242790.
    KOiK01866.
    OMAiTTIRYNS.
    OrthoDBiEOG6B09VR.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_02006. Tyr_tRNA_synth_type1.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002942. S4_RNA-bd.
    IPR002307. Tyr-tRNA-ligase.
    IPR024088. Tyr-tRNA-ligase_bac-type.
    IPR024107. Tyr-tRNA-ligase_bac_1.
    [Graphical view]
    PANTHERiPTHR11766. PTHR11766. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01040. TRNASYNTHTYR.
    TIGRFAMsiTIGR00234. tyrS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q57DI5-1 [UniParc]FASTAAdd to Basket

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    MSGFKSDFLR TLSERGFIHQ ISDESGLDEL LAKETVTAYI GFDPTAPSLH    50
    AGGLIQIMML YWLQQTGHKP VALMGGGTGM VGDPSFKDEA RKLMTEDTIA 100
    ENMASIKRVF ANYLTFGDGA NDALMVNNGE WLRNINYLEF LRDVGRHFSV 150
    NRMLSFDSVK LRLDREQSLS FLEFNYMILQ AYDFVELNKR YGLRLQMGGS 200
    DQWGNIVNGI DLGHRMGTPQ LYALTSPLLT TASGQKMGKS LGGAIWLNAD 250
    MLSAYDFWQY WRNTEDADVE RFLKLYTTLP LDEIARLAEL GGAEINEAKK 300
    ILATEVTAML HGRDAAEEAA ETARKTFEDG ELSENLPTVG VHKATLNDGI 350
    GVLALMVLAE LCTTNGEARR HVEGGAVRIN DEPVSDPRMV VNAAALNDQG 400
    LIKLSLGKKR HVLIRPA 417
    Length:417
    Mass (Da):46,157
    Last modified:May 10, 2005 - v1
    Checksum:i2D734F3E7A2D83EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74299.1.
    RefSeqiYP_221660.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74299; AAX74299; BruAb1_0935.
    GeneIDi3341098.
    KEGGibmb:BruAb1_0935.
    PATRICi17823508. VBIBruAbo15061_0984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017223 Genomic DNA. Translation: AAX74299.1 .
    RefSeqi YP_221660.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q57DI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_0935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74299 ; AAX74299 ; BruAb1_0935 .
    GeneIDi 3341098.
    KEGGi bmb:BruAb1_0935.
    PATRICi 17823508. VBIBruAbo15061_0984.

    Phylogenomic databases

    eggNOGi COG0162.
    HOGENOMi HOG000242790.
    KOi K01866.
    OMAi TTIRYNS.
    OrthoDBi EOG6B09VR.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-949-MONOMER.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_02006. Tyr_tRNA_synth_type1.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002942. S4_RNA-bd.
    IPR002307. Tyr-tRNA-ligase.
    IPR024088. Tyr-tRNA-ligase_bac-type.
    IPR024107. Tyr-tRNA-ligase_bac_1.
    [Graphical view ]
    PANTHERi PTHR11766. PTHR11766. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01040. TRNASYNTHTYR.
    TIGRFAMsi TIGR00234. tyrS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiSYY_BRUAB
    AccessioniPrimary (citable) accession number: Q57DI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3