Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anhydro-N-acetylmuramic acid kinase

Gene

anmK

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.UniRule annotation

Catalytic activityi

ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. phosphotransferase activity, alcohol group as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Source: UniProtKB-UniPathway
  2. amino sugar metabolic process Source: UniProtKB-HAMAP
  3. carbohydrate metabolic process Source: UniProtKB-KW
  4. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-950-MONOMER.
UniPathwayiUPA00343.
UPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
Anhydro-N-acetylmuramic acid kinaseUniRule annotation (EC:2.7.1.170UniRule annotation)
Alternative name(s):
AnhMurNAc kinaseUniRule annotation
Gene namesi
Name:anmKUniRule annotation
Ordered Locus Names:BruAb1_0936
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Anhydro-N-acetylmuramic acid kinasePRO_0000249980Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb1_0936.

Family & Domainsi

Sequence similaritiesi

Belongs to the anhydro-N-acetylmuramic acid kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2377.
HOGENOMiHOG000256308.
KOiK09001.
OMAiFRRKDMA.
OrthoDBiEOG64N9WW.

Family and domain databases

HAMAPiMF_01270. AnhMurNAc_kinase.
InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view]
PfamiPF03702. UPF0075. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDLKRAIGL MSGTSMDGID IALLATDGEN WIERRASASM DYSDGFRARL
60 70 80 90 100
KAGLVDARAI KDRAERPGLL RQLEHDLTLL HAVAVHDFLH EQGLQPHEID
110 120 130 140 150
VIGFHGQTVL HRPNESLTVQ IGDGALLARE TGIPVVYDMR AEDMRHGGQG
160 170 180 190 200
APLIPAYHAA LAANLPLGLK GPVVFVNIGG ISNLTYVGED GALIAYDSGP
210 220 230 240 250
GNMLIDQWME LHGHGRFDPG GATAMSGSVD RNTAHRYLEH EFFKGNHRRS
260 270 280 290 300
LDRGDFAIPA KGELNLADGA RTLAFVSAAA ILKSASHLPA RPRTYVVSGG
310 320 330 340 350
GRKNGALMDE LTALAEREGA HVIDADNAGF DGDAMEAEAW AYLAVRSLCG
360 370
LPLTYPSTTG CDKPVSGGVP VRP
Length:373
Mass (Da):39,828
Last modified:May 10, 2005 - v1
Checksum:iF12C16EFF7C8773F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74300.1.
RefSeqiYP_221661.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74300; AAX74300; BruAb1_0936.
KEGGibmb:BruAb1_0936.
PATRICi17823510. VBIBruAbo15061_0985.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017223 Genomic DNA. Translation: AAX74300.1.
RefSeqiYP_221661.1. NC_006932.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi262698.BruAb1_0936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX74300; AAX74300; BruAb1_0936.
KEGGibmb:BruAb1_0936.
PATRICi17823510. VBIBruAbo15061_0985.

Phylogenomic databases

eggNOGiCOG2377.
HOGENOMiHOG000256308.
KOiK09001.
OMAiFRRKDMA.
OrthoDBiEOG64N9WW.

Enzyme and pathway databases

UniPathwayiUPA00343.
UPA00544.
BioCyciBABO262698:GJC2-950-MONOMER.

Family and domain databases

HAMAPiMF_01270. AnhMurNAc_kinase.
InterProiIPR005338. Anhydro_N_Ac-Mur_kinase.
[Graphical view]
PfamiPF03702. UPF0075. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiANMK_BRUAB
AccessioniPrimary (citable) accession number: Q57DI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 10, 2005
Last modified: April 1, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.