Q57DI4 (ANMK_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anhydro-N-acetylmuramic acid kinase
EC=2.7.1.170

Alternative name(s):
AnhMurNAc kinase

Gene names

Name:	anmK
Ordered Locus Names:	BruAb1_0936

Organism

Brucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]

Taxonomic identifier

262698 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella abortus › Brucella abortus bv. 1

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling By similarity. HAMAP-Rule MF_01270
Catalytic activity	ATP + 1,6-anhydro-N-acetyl-beta-muramate + H2O = ADP + N-acetylmuramate 6-phosphate. HAMAP-Rule MF_01270
Pathway	Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation. HAMAP-Rule MF_01270 Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_01270
Sequence similarities	Belongs to the anhydro-N-acetylmuramic acid kinase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	1,6-anhydro-N-acetyl-beta-muramic acid catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway amino sugar metabolic process Inferred from electronic annotation. Source: HAMAP carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP kinase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Anhydro-N-acetylmuramic acid kinase HAMAP-Rule MF_01270		PRO_0000249980
Regions
	Nucleotide binding	13 – 20	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q57DI4 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: F12C16EFF7C8773F	FASTA	373	39,828
	10 20 30 40 50 60 MPDLKRAIGL MSGTSMDGID IALLATDGEN WIERRASASM DYSDGFRARL KAGLVDARAI 70 80 90 100 110 120 KDRAERPGLL RQLEHDLTLL HAVAVHDFLH EQGLQPHEID VIGFHGQTVL HRPNESLTVQ 130 140 150 160 170 180 IGDGALLARE TGIPVVYDMR AEDMRHGGQG APLIPAYHAA LAANLPLGLK GPVVFVNIGG 190 200 210 220 230 240 ISNLTYVGED GALIAYDSGP GNMLIDQWME LHGHGRFDPG GATAMSGSVD RNTAHRYLEH 250 260 270 280 290 300 EFFKGNHRRS LDRGDFAIPA KGELNLADGA RTLAFVSAAA ILKSASHLPA RPRTYVVSGG 310 320 330 340 350 360 GRKNGALMDE LTALAEREGA HVIDADNAGF DGDAMEAEAW AYLAVRSLCG LPLTYPSTTG 370 CDKPVSGGVP VRP

References

[1]

"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis." Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C. J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 9-941.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017223 Genomic DNA. Translation: AAX74300.1.
RefSeq	YP_221661.1. NC_006932.1.
3D structure databases
ProteinModelPortal	Q57DI4.
ModBase	Search...
Protein-protein interaction databases
STRING	262698.BruAb1_0936.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAX74300; AAX74300; BruAb1_0936.
GeneID	3340124.
KEGG	bmb:BruAb1_0936.
PATRIC	17823510. VBIBruAbo15061_0985.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2377.
HOGENOM	HOG000256308.
KO	K09001.
OMA	YIGLMSG.
ProtClustDB	PRK09585.
Enzyme and pathway databases
BioCyc	BABO262698:GJC2-950-MONOMER.
UniPathway	UPA00343. UPA00544.
Family and domain databases
HAMAP	MF_01270. AnhMurNAc_kinase.
InterPro	IPR005338. Anhydro_N_Ac-Mur_kinase. [Graphical view]
Pfam	PF03702. UPF0075. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANMK_BRUAB

Accession

Primary (citable) accession number: Q57DI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	May 10, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program