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Q57DG3

- MOAA_BRUAB

UniProt

Q57DG3 - MOAA_BRUAB

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Protein
Cyclic pyranopterin monophosphate synthase
Gene
moaA, BruAb1_0964
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) By similarity.UniRule annotation

Catalytic activityi

GTP = cyclic pyranopterin phosphate + diphosphate.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. Binds 1 4Fe-4S cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 4Fe-4S cluster coordinated with 3 cysteines and the GTP-derived substrate By similarity.
Binds 1 S-adenosyl-L-methionine per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281GTP By similarity
Metal bindingi35 – 351Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi39 – 391Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei41 – 411S-adenosyl-L-methionine By similarity
Metal bindingi42 – 421Iron-sulfur 1 (4Fe-4S-S-AdoMet) By similarity
Binding sitei77 – 771GTP By similarity
Binding sitei81 – 811S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei111 – 1111GTP By similarity
Binding sitei135 – 1351S-adenosyl-L-methionine By similarity
Binding sitei171 – 1711GTP By similarity
Binding sitei205 – 2051S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi268 – 2681Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi271 – 2711Iron-sulfur 2 (4Fe-4S-substrate) By similarity
Metal bindingi285 – 2851Iron-sulfur 2 (4Fe-4S-substrate) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. GTP binding Source: UniProtKB-KW
  3. cyclic pyranopterin monophosphate synthase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Keywords - Ligandi

4Fe-4S, GTP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBABO262698:GJC2-979-MONOMER.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic pyranopterin monophosphate synthase (EC:4.1.99.18)
Alternative name(s):
Molybdenum cofactor biosynthesis protein A
Gene namesi
Name:moaA
Ordered Locus Names:BruAb1_0964
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. molybdopterin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Cyclic pyranopterin monophosphate synthaseUniRule annotation
PRO_1000054176Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi262698.BruAb1_0964.

Structurei

3D structure databases

ProteinModelPortaliQ57DG3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni273 – 2753GTP binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2896.
HOGENOMiHOG000228680.
KOiK03639.
OMAiCLGQEDM.
OrthoDBiEOG64XXNN.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01225_B. MoaA_B.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view]
PfamiPF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02666. moaA. 1 hit.
PROSITEiPS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q57DG3-1 [UniParc]FASTAAdd to Basket

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MRNVQDQPLV SPTEPMIDPF GRAVTYLRVS VTDRCDFRCT YCMAEHMTFL    50
PKKDLLTLEE LDRLCSVFIE KGVRKLRLTG GEPLVRKNIM HLIGNLSRHL 100
KSGALDELTL TTNGSQLARF AGELADCGVR RINVSLDTLN PEKFRTITRW 150
GDLSRVLEGI DAAQKAAIHV KINAVALKDF NDAEIPELIR WAHGRGMDVT 200
LIETMPMGEI EFDRTDQYLP LSQVRADLAS QFTLADIPYR TGGPARYVTI 250
SETGGRLGFI TPMTYNFCES CNRVRLTCTG MLYMCLGQND DADLRKALRE 300
SESDEHLSQA IDEAISRKPK GHDFIIDREH NRPSVARHMS LTGG 344
Length:344
Mass (Da):38,687
Last modified:May 10, 2005 - v1
Checksum:i50B8258570E51148
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74321.1.
RefSeqiYP_221682.1. NC_006932.1.

Genome annotation databases

EnsemblBacteriaiAAX74321; AAX74321; BruAb1_0964.
GeneIDi3340016.
KEGGibmb:BruAb1_0964.
PATRICi17823572. VBIBruAbo15061_1015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017223 Genomic DNA. Translation: AAX74321.1 .
RefSeqi YP_221682.1. NC_006932.1.

3D structure databases

ProteinModelPortali Q57DG3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 262698.BruAb1_0964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX74321 ; AAX74321 ; BruAb1_0964 .
GeneIDi 3340016.
KEGGi bmb:BruAb1_0964.
PATRICi 17823572. VBIBruAbo15061_1015.

Phylogenomic databases

eggNOGi COG2896.
HOGENOMi HOG000228680.
KOi K03639.
OMAi CLGQEDM.
OrthoDBi EOG64XXNN.

Enzyme and pathway databases

UniPathwayi UPA00344 .
BioCyci BABO262698:GJC2-979-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01225_B. MoaA_B.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR013483. MoaA.
IPR000385. MoaA_NifB_PqqE_Fe-S-bd_CS.
IPR010505. Mob_synth_C.
IPR007197. rSAM.
[Graphical view ]
Pfami PF06463. Mob_synth_C. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02666. moaA. 1 hit.
PROSITEi PS01305. MOAA_NIFB_PQQE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiMOAA_BRUAB
AccessioniPrimary (citable) accession number: Q57DG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 10, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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